INT39077

Context Info Confidence 0.05 First Reported 1985 Last Reported 1985 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.46

peptidase activity (Prss12) extracellular space (Agt) aging (Agt) extracellular region (Agt) extracellular matrix organization (Agt)

Agt (Rattus norvegicus) Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat bradykinin 5 100.00 Intracerebroventricular 4 92.96 Enkephalin 1 81.32

Disease Link Frequency Relevance Heat Hypertension 6 99.86

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In both acute and chronic 2K-1C hypertensive rats, ANG II and BK significantly suppressed PRA, NT did not affect PRA, and Leu-ENK produced a significant increase in PRA followed by a significant decrease in PRA.

ANG II Negative_regulation (suppressed) of NT associated with hypertension and bradykinin

1) Confidence 0.05 Published 1985 Journal Jpn Heart J Section Abstract Doc Link 3903250 Disease Relevance 0.44 Pain Relevance 0.46

General Comments

This test has worked.