INT39079

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Context Info
Confidence 0.17
First Reported 1984
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.87
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Mention Frequency
plasma 1
renal nerve 1
Agt (Rattus norvegicus)
pra (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
bradykinin 25 100.00 Very High Very High Very High
Intracerebroventricular 17 99.52 Very High Very High Very High
Enkephalin 6 97.56 Very High Very High Very High
Disease Term Frequency Confidence Heat
Hypertension 12 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both acute and chronic 2K-1C hypertensive rats, ANG II and BK significantly suppressed PRA, NT did not affect PRA, and Leu-ENK produced a significant increase in PRA followed by a significant decrease in PRA.
ANG II Negative_regulation (suppressed) of PRA associated with hypertension and bradykinin
1) Confidence 0.17 Published 1985 Journal Jpn Heart J Section Abstract Doc Link 3903250 Disease Relevance 0.44 Pain Relevance 0.46
As compared to normal rats, suppression of PRA by ANG II and NT was attenuated or abolished but BK and Leu-ENK produced significant reductions in PRA in 2K-1C hypertensive rats.
ANG II Negative_regulation (suppression) of PRA associated with hypertension and bradykinin
2) Confidence 0.15 Published 1985 Journal Jpn Heart J Section Abstract Doc Link 3903250 Disease Relevance 0.43 Pain Relevance 0.44
Although suppression of PRA is mainly mediated by mechanisms other than the renal nerve, the renal nerve partially participates in suppression of PRA by ANG II.
ANG II Negative_regulation (suppression) of PRA in renal nerve
3) Confidence 0.12 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3903540 Disease Relevance 0 Pain Relevance 0.31
Suppression of PRA by ANG II was attenuated in denervated rats.
ANG II Negative_regulation (Suppression) of PRA
4) Confidence 0.12 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3903540 Disease Relevance 0 Pain Relevance 0.36
In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), BK did not affect PRA, and Leu-ENK increased PRA.
ANG II Negative_regulation (suppressed) of PRA in plasma associated with bradykinin
5) Confidence 0.10 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3903540 Disease Relevance 0 Pain Relevance 0.37
ANG II and NT significantly suppressed PRA, BK did not affect PRA, and Leu-ENK significantly increased PRA.
ANG II Negative_regulation (suppressed) of PRA associated with bradykinin
6) Confidence 0.07 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6375907 Disease Relevance 0 Pain Relevance 0.35

General Comments

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