INT39108

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Context Info
Confidence 0.50
First Reported 1985
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PDYN, YY1) cell differentiation (YY1) intracellular (YY1)
DNA binding (YY1) extracellular region (PDYN) cell death (PDYN)
PDYN (Homo sapiens)
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
opioid receptor 2 99.64 Very High Very High Very High
Analgesic 4 97.84 Very High Very High Very High
Endogenous opioid 1 96.80 Very High Very High Very High
intrathecal 2 95.44 Very High Very High Very High
Lasting pain 2 88.16 High High
opiate 3 78.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 2 89.84 High High
Pain 4 88.16 High High
Sleep Disorders 1 52.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-Ala-D-Leu-enkephalin (DADL) is a pentapeptide which, compared to morphine, preferentially binds to the delta receptor.
D-Ala-D-Leu-enkephalin Binding (binds) of delta associated with enkephalin and morphine
1) Confidence 0.50 Published 1985 Journal Pain Section Abstract Doc Link 3906516 Disease Relevance 0.44 Pain Relevance 1.45
Here, we characterized interactions of big dynorphin (Big Dyn), a 32-amino acid prodynorphin-derived peptide consisting of Dyn A and Dyn B, with human KOR, mu- (hMOR) and delta- (hDOR) opioid receptors and opioid receptor-like receptor 1 (hORL1) expressed in cells transfected with respective cDNA.
big dynorphin Binding (interactions) of delta associated with dynorphin, kappa opioid receptor and opioid receptor
2) Confidence 0.08 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.69

General Comments

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