INT3911

Context Info Confidence 0.65 First Reported 1977 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 29 Total Number 32 Disease Relevance 21.68 Pain Relevance 1.85

endosome (TNFAIP1) nucleolus (TNFAIP1) nucleus (TNFAIP1) embryo development (TNFAIP1) cytoplasm (TNFAIP1)

Anatomy Link Frequency B12 29 blood 1 motor neuron 1 parathyroid 1 TNFAIP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 5 99.68 Spinal cord 12 96.20 psoriasis 2 95.92 Inflammation 42 93.16 peripheral neuropathy 12 92.80 Chronic pancreatitis 55 92.64 cva 19 92.28 spinal inflammation 1 92.04 imagery 29 89.48 Etanercept 53 85.52

Disease Link Frequency Relevance Heat Motor Neuron Diseases 352 99.80 Neuropathy 8 99.78 Mycobacterial Infection 87 99.68 Subacute Combined Degeneration 20 99.44 Malignant Neoplastic Disease 69 99.12 Cancer 79 98.60 Hypercalcemia 152 98.12 Peripheral Neuropathy 16 97.96 Glaucoma 1 97.16 Appetite Loss 28 97.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In ophthalmology, Shin and Becker have shown that the prevalence of HLA B7 and B12 antigens was significantly higher in patients with primary open-angle glaucoma than in the non-glaucomatous population.

Gene_expression (prevalence) of B12 in B12 associated with glaucoma

1) Confidence 0.65 Published 1977 Journal Ann Ophthalmol Section Abstract Doc Link 911119 Disease Relevance 0.89 Pain Relevance 0.14

Serum B12 levels

Gene_expression (levels) of B12 in B12

2) Confidence 0.60 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

Patients willing to try oral therapy were given a six-month supply of B12 tablets (one 1000 ?

Gene_expression (tablets) of B12 in B12

3) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

We placed the initial questionnaire [see Additional file 1 ] in patients' charts to be completed at their next visit for a B12 injection.

Gene_expression (injection) of B12 in B12

4) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

Perceived efficacy of B12 therapy

Gene_expression (therapy) of B12 in B12

5) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

The recruitment cover letter included one sentence describing the equivalency of oral B12 therapy to injections: "Studies have shown that vitamin B12 pills are just as effective and safe as B12 injections."

Gene_expression (injections) of B12 in B12

6) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

For both patients interviewed during their trial of oral B12 and for three of the five patients interviewed afterward, all of whom permanently switched to oral therapy, there was a high level of satisfaction with oral B12.

Gene_expression (satisfaction) of B12 in B12

7) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0.07 Pain Relevance 0

The recruitment cover letter included one sentence describing the equivalency of oral B12 therapy to injections: "Studies have shown that vitamin B12 pills are just as effective and safe as B12 injections."

Gene_expression (injections) of B12 in B12

8) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

By monitoring trough serum B12 levels (i.e., 1 month after their last injection) and again 6 months after oral therapy, we observed that one patient was a non-responder (i.e., serum level decreased), and 4 patients had serum levels that increased but remained below 295 pmol/L (a level considered by some to be borderline B12 deficient)[17].

Gene_expression (deficient) of B12 in B12

9) Confidence 0.52 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

Baseline and post-intervention serum B12 levels were obtained for 39 of the 55 patients who switched to pills (Figure 2).

Gene_expression (levels) of B12 in B12

10) Confidence 0.47 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0

Expression of the TNF-related proteins TNFAIP1 (B12), which is a membrane-located ion channel and a direct target of TNF-induced signaling, transforming growth factor alpha (TGF-?)

Gene_expression (Expression) of B12 in B12

11) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.72 Pain Relevance 0.08

Expression of the TNF-related proteins TNFAIP1 (B12), which is a membrane-located ion channel and a direct target of TNF-induced signaling, transforming growth factor alpha (TGF-?)

Gene_expression (Expression) of TNFAIP1 in B12

12) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.72 Pain Relevance 0.08

They will be asked to continue to participate as part of the 'comprehensive cohort study' and will be referred back to their GP for immediate treatment with B12 injections.

Gene_expression (injections) of B12 in B12

13) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.54 Pain Relevance 0.14

Those patients with B12 deficiency must not receive folate and will be excluded from the trial.

Gene_expression (deficiency) of B12 in B12

14) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.57 Pain Relevance 0.15

Patients whose blood results show B12 deficiency will be referred back to their GP for immediate treatment with B12 injections.

Gene_expression (injections) of B12 in blood

15) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0 Pain Relevance 0.08

Expression of the TNF-related proteins TNFAIP1 (B12), which is a membrane-located ion channel and a direct target of TNF-induced signaling, transforming growth factor alpha (TGF-?)

Gene_expression (Expression) of B12 in B12

16) Confidence 0.37 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.72 Pain Relevance 0.08

Laboratory examination was unremarkable, with a normal CBC, serum folate, free T4 index, serum vitamin B12, creatinine, and hemoglobin A1c.

Gene_expression (unremarkable) of B12 in B12

17) Confidence 0.29 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2500042 Disease Relevance 0.96 Pain Relevance 0.04

Serum B12 levels should be checked, especially in patients who present with other known neuropsychiatric features of vitamin B12 deficiency [3].

Gene_expression (levels) of B12 in B12

18) Confidence 0.26 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2329654 Disease Relevance 1.22 Pain Relevance 0.17

At present, our patient has been treated for vitamin B12 deficiency and M. tuberculosis.

Gene_expression (deficiency) of B12 in B12 associated with mycobacterial infection

19) Confidence 0.26 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2329654 Disease Relevance 0.87 Pain Relevance 0

Neuropathy caused by B12 deficiency in a patient with ileal tuberculosis: A case report Introduction

Gene_expression (deficiency) of B12 in B12 associated with mycobacterial infection and neuropathy

20) Confidence 0.26 Published 2008 Journal J Med Case Reports Section Title Doc Link PMC2329654 Disease Relevance 1.64 Pain Relevance 0

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