INT3913

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 47
Total Number 52
Disease Relevance 22.73
Pain Relevance 33.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 5
liver 4
neurons 4
efferent neurons 2
plasma 1
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 750 100.00 Very High Very High Very High
Glutamate 120 100.00 Very High Very High Very High
Neurotransmitter 62 100.00 Very High Very High Very High
GABA receptor 16 100.00 Very High Very High Very High
c fibre 126 99.96 Very High Very High Very High
Gabapentin 38 99.92 Very High Very High Very High
pain flank 1 99.92 Very High Very High Very High
antagonist 80 99.80 Very High Very High Very High
alcohol 110 99.46 Very High Very High Very High
anticonvulsant 11 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 178 99.98 Very High Very High Very High
Hepatitis 6 99.92 Very High Very High Very High
Flank Pain 1 99.92 Very High Very High Very High
Disease 102 99.90 Very High Very High Very High
Muscular Spasm 3 99.90 Very High Very High Very High
Hepatic Insufficiency 5 99.88 Very High Very High Very High
Bartter Syndrome 1 99.88 Very High Very High Very High
Post-traumatic Stress Disorder 186 99.84 Very High Very High Very High
Appetite Loss 44 99.72 Very High Very High Very High
Exanthema 22 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relatively rigid cage structure of these bicyclic monoterpenes and their high efficacy may aid in a greater understanding of molecular aspects of positive modulation of the activation of GABA(A) receptors.
Positive_regulation (activation) of GABA associated with gaba
1) Confidence 0.69 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.42
The 59-year-old man was admitted to our hospital because of progressive appetite loss and markedly elevated serum transaminase.
Positive_regulation (elevated) of serum transaminase associated with appetite loss
2) Confidence 0.68 Published 2009 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 19212212 Disease Relevance 1.47 Pain Relevance 0.08
Painful tonic heat stimulation induces GABA accumulation in the prefrontal cortex in man.
Positive_regulation (accumulation) of GABA in prefrontal associated with pain and gaba
3) Confidence 0.60 Published 2009 Journal Pain Section Title Doc Link 19167811 Disease Relevance 0.24 Pain Relevance 1.78
Compared to non-painful stimulation, painful tonic heat was associated with a significant increase in GABA concentrations in the rACC.
Positive_regulation (increase) of GABA associated with pain and gaba
4) Confidence 0.60 Published 2009 Journal Pain Section Abstract Doc Link 19167811 Disease Relevance 0.23 Pain Relevance 1.61
We used proton magnetic resonance spectroscopy (1H-MRS) during tonic painful heat stimulation to test the hypothesis of increases in both glutamate and GABA, two neurotransmitters with a key role in pain processing.
Positive_regulation (increases) of GABA associated with pain, neurotransmitter, gaba and glutamate
5) Confidence 0.60 Published 2009 Journal Pain Section Abstract Doc Link 19167811 Disease Relevance 0.19 Pain Relevance 1.12
Therefore a therapeutic strategy for these diseases may be supplementary treatment with drugs which increase GABA receptor activity.
Positive_regulation (increase) of GABA associated with gaba receptor and disease
6) Confidence 0.55 Published 1982 Journal Pharm Weekbl Sci Section Abstract Doc Link 6292818 Disease Relevance 0.91 Pain Relevance 0.83
Serum transaminase levels were suddenly elevated, and computed tomography scans of the liver showed multiple small nodular lesions.
Positive_regulation (elevated) of Serum transaminase in liver
7) Confidence 0.54 Published 1997 Journal J. Gastroenterol. Section Abstract Doc Link 9349998 Disease Relevance 1.40 Pain Relevance 0.26
However, despite this apparent increase in the glutathione protective capacity of the liver, acetaminophen-induced hepatic necrosis was modestly potentiated by fasting, as judged by liver histology and elevation of serum transaminase (SGOT) activity.
Positive_regulation (elevation) of serum transaminase in liver associated with necrosis and paracetamol
8) Confidence 0.50 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3754139 Disease Relevance 0.34 Pain Relevance 0.58
At high concentrations (>1.5mM) (+)- and (-)-borneol directly activated GABA(A) receptors producing 89% and 84%, respectively, of the maximal GABA response indicative of a weak partial agonist action.
Positive_regulation (activated) of GABA associated with gaba and agonist
9) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.62
High fever continued for 11 days after the spasm and serum transaminase was elevated.
Positive_regulation (elevated) of serum transaminase associated with muscular spasm and fever
10) Confidence 0.46 Published 1987 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3037294 Disease Relevance 1.29 Pain Relevance 0.20
Although the neuropharmacologic mechanism of action of propofol has not yet been elucidated completely, there is evidence suggesting that propofol may potentiate GABA-evoked responses and may activate the GABA-A receptors [68].
Positive_regulation (activate) of GABA associated with gaba
11) Confidence 0.44 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.39 Pain Relevance 0.35
GVG is an antiepileptic that elevates brain GABA concentrations by inhibiting an enzyme, GABA transaminase, that breaks down the neurotransmitter.
Positive_regulation (elevates) of GABA in brain associated with neurotransmitter and gaba
12) Confidence 0.43 Published 2008 Journal Addiction Science & Clinical Practice Section Body Doc Link PMC2797110 Disease Relevance 0.14 Pain Relevance 1.21
Gabapentin appears to increase human brain GABA levels.
Spec (appears) Positive_regulation (increase) of GABA in brain associated with gaba and gabapentin
13) Confidence 0.41 Published 1996 Journal Ann. Neurol. Section Abstract Doc Link 8572673 Disease Relevance 0.24 Pain Relevance 0.77
GABA was elevated in patients taking gabapentin compared with 14 complex partial epilepsy patients, matched for antiepileptic drug treatment.
Positive_regulation (elevated) of GABA associated with complex partial epilepsy, gaba and gabapentin
14) Confidence 0.41 Published 1996 Journal Ann. Neurol. Section Abstract Doc Link 8572673 Disease Relevance 0.26 Pain Relevance 0.78
Gabapentin is an anticonvulsant medication that increases human brain GABA levels.
Positive_regulation (increases) of GABA in brain associated with gaba and anticonvulsant
15) Confidence 0.41 Published 2006 Journal Drug Alcohol Depend Section Abstract Doc Link 16169160 Disease Relevance 0.27 Pain Relevance 0.76
CONCLUSION: This study demonstrates that single doses of topiramate and gabapentin increase cerebral GABA concentrations acutely (hours) in healthy individuals, but all drugs at clinically utilized doses increase cerebral GABA at 4 weeks.
Positive_regulation (increase) of GABA
16) Confidence 0.41 Published 2002 Journal Neurology Section Body Doc Link 11839834 Disease Relevance 0 Pain Relevance 0
With long-term dosing and once target doses were achieved at 4 weeks, significant elevations in GABA were observed compared with baseline for all three drugs (topiramate 46%, gabapentin 25%, lamotrigine 25%).
Positive_regulation (elevations) of GABA
17) Confidence 0.41 Published 2002 Journal Neurology Section Body Doc Link 11839834 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This study demonstrates that single doses of topiramate and gabapentin increase cerebral GABA concentrations acutely (hours) in healthy individuals, but all drugs at clinically utilized doses increase cerebral GABA at 4 weeks.
Positive_regulation (increase) of GABA
18) Confidence 0.41 Published 2002 Journal Neurology Section Body Doc Link 11839834 Disease Relevance 0 Pain Relevance 0
However, in the rat neocortical slice exposed to the same conditions as the human tissue, gabapentin did not increase GABA significantly.
Neg (not) Positive_regulation (increase) of GABA associated with gaba and gabapentin
19) Confidence 0.41 Published 2002 Journal Epilepsy Res. Section Abstract Doc Link 12076841 Disease Relevance 0.19 Pain Relevance 0.84
Gabapentin significantly increased GABA concentrations by 13% (P<0.02) in human neocortical slices made from tissue resected during epilepsy surgery.
Positive_regulation (increased) of GABA associated with epilepsy, gaba and gabapentin
20) Confidence 0.41 Published 2002 Journal Epilepsy Res. Section Abstract Doc Link 12076841 Disease Relevance 0.17 Pain Relevance 0.84

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