INT39134

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Context Info
Confidence 0.14
First Reported 1985
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.57
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ace2) extracellular space (Ace2) extracellular region (Ace2)
plasma membrane (Ace2)
Anatomy Link Frequency
plasma 2
Ace2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 99.90 Very High Very High Very High
antagonist 4 97.92 Very High Very High Very High
anesthesia 2 86.56 High High
Disease Link Frequency Relevance Heat
Hypertension 8 75.00 Quite High
Targeted Disruption 4 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result pointed once again to a permissive interaction between morphine and circulating angiotensin I or renin.
Positive_regulation (circulating) of angiotensin I associated with morphine
1) Confidence 0.14 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 0.87
Exposure to the low-salt diet increased plasma renin activity and elevated plasma levels of angiotensin I and angiotensin II in SHR by 81% and 68%, respectively, above values determined in SHR fed a normal salt diet.
Positive_regulation (increased) of angiotensin I in plasma
2) Confidence 0.13 Published 2000 Journal Hypertension Section Abstract Doc Link 10988275 Disease Relevance 0.29 Pain Relevance 0.14
Exposure to the low-salt diet increased plasma renin activity and elevated plasma levels of angiotensin I and angiotensin II in SHR by 81% and 68%, respectively, above values determined in SHR fed a normal salt diet.
Positive_regulation (elevated) of angiotensin I in plasma
3) Confidence 0.09 Published 2000 Journal Hypertension Section Abstract Doc Link 10988275 Disease Relevance 0.28 Pain Relevance 0.13
We interpreted this drinking response as being the sum of morphine-induced drinking (following a permissive interaction between morphine and circulating angiotensin I or renin) and captopril-induced drinking (following a captopril-induced increase in circulating renin and angiotensin I levels).
Positive_regulation (increase) of angiotensin I associated with morphine
4) Confidence 0.08 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 0.99

General Comments

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