INT39144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.56
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2)
cytoplasm (RIPK2) signal transducer activity (RIPK2)
Anatomy Link Frequency
CER 1
RIPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 100.00 Very High Very High Very High
Cholecystokinin 2 99.40 Very High Very High Very High
antinociception 1 96.88 Very High Very High Very High
Inflammation 78 95.60 Very High Very High Very High
Enkephalin 8 95.52 Very High Very High Very High
antagonist 2 95.36 Very High Very High Very High
Chronic pancreatitis 2 88.60 High High
metalloproteinase 6 80.76 Quite High
analgesia 1 77.52 Quite High
Opioid 1 73.52 Quite High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 98.80 Very High Very High Very High
Osteogenic Sarcomas 6 97.60 Very High Very High Very High
Apoptosis 15 97.48 Very High Very High Very High
Anxiety Disorder 4 97.32 Very High Very High Very High
Periodontitis 48 96.98 Very High Very High Very High
Sleep Disorders 2 96.20 Very High Very High Very High
Catalepsy 1 95.80 Very High Very High Very High
INFLAMMATION 81 95.60 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 95.36 Very High Very High Very High
Panic Disorder 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and water; antinociception; sedation; catalepsy; ptosis, antistereotypic, anticonvulsive and tremorolytic effects; inhibition of self-stimulation.
Gene_expression (produce) of CCK in CER associated with antinociception, catalepsy, ocular toxicity (including many sub-types) and sleep disorders
1) Confidence 0.75 Published 1985 Journal Peptides Section Abstract Doc Link 3913910 Disease Relevance 0.37 Pain Relevance 0.22
Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and animal models of anxiety.
Gene_expression (expression) of CCK associated with suicidal behaviour and anxiety disorder
2) Confidence 0.75 Published 2006 Journal Amino Acids Section Abstract Doc Link 16738800 Disease Relevance 0.52 Pain Relevance 0.15
Kinetics of hydrolysis of CCK-like peptides indicated a rapid processing of CCK-4 and a slower breakdown of CCK-8 (with a greater resistance of the sulfated form of CCK-8 as compared to the unsulfated peptide).
Gene_expression (processing) of CCK
3) Confidence 0.65 Published 1981 Journal Peptides Section Abstract Doc Link 6283489 Disease Relevance 0 Pain Relevance 0.45
The S test and CCK-pancreozymin (PZ) test (PS test) were introduced into Japan around 1963 and have been used as the gold standard of the exocrine pancreatic-function test.
Gene_expression (introduced) of CCK associated with bile
4) Confidence 0.65 Published 1998 Journal Pancreas Section Abstract Doc Link 9548677 Disease Relevance 0.16 Pain Relevance 0.21
The 5% least expressed genes were Receptor-interacting serine/threonine kinase-2 (RIP-2, NM_003821, 0.01-fold), Complement component 3 (C3, NM_000064, 0.02-fold), Prostaglandin-endoperoxide synthase-2 (COX-2, NM_000963, 0.02-fold), Interleukin-8 (IL-8, NM_000584, 0.02-fold), Endothelin-1 (EDN-1, NM_001955, 0.03-fold), Plasminogen activator inhibitor type-2 (PAI-2, NM_000602, 0.04-fold), Matrixmetalloproteinase-14 (MMP-14, NM_004995, 0.04-fold), and Interferon regulating factor-7 (IRF-7, NM_00157, 0.05-fold) (Figure 1, 2, 3).
Gene_expression (expressed) of RIP-2
5) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.60 Pain Relevance 0.08
The increased expression of BIRC-1, a potent inhibitor of activated caspase-3 and -7 [26] and the decreased expression of RIP-2, a strong activator of NF-?
Gene_expression (expression) of RIP-2
6) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.40 Pain Relevance 0.11
It has been described that in untreated periodontitis sites, the activity of caspase-3, -7, and Fas is increased compared to healthy tissues [28] and thus the up-regulation of BIRC-1 as well as decreased expression of RIP-2 may represent different protective host mechanisms to control apoptotic processes following periodontal therapy.
Gene_expression (expression) of RIP-2 associated with periodontitis and apoptosis
7) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.50 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox