INT3915

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 13.94
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (SCD) endoplasmic reticulum (SCD)
Anatomy Link Frequency
liver 3
plasma 1
ovary 1
urine 1
SCD (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 69 100.00 Very High Very High Very High
agonist 15 99.82 Very High Very High Very High
Cannabinoid 23 99.64 Very High Very High Very High
withdrawal 7 99.60 Very High Very High Very High
Eae 1 98.96 Very High Very High Very High
Morphine 14 98.12 Very High Very High Very High
opiate 8 97.80 Very High Very High Very High
Pain 60 97.56 Very High Very High Very High
analgesia 5 97.56 Very High Very High Very High
Potency 2 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 214 100.00 Very High Very High Very High
Depression 71 100.00 Very High Very High Very High
Myocardial Infarction 54 100.00 Very High Very High Very High
Thalassemia 33 100.00 Very High Very High Very High
Ataxia 1 100.00 Very High Very High Very High
Myelodysplastic Syndromes 19 99.80 Very High Very High Very High
Chronic Disease 28 99.68 Very High Very High Very High
Arrhythmias 2 Under Development 12 99.32 Very High Very High Very High
Cancer 97 98.76 Very High Very High Very High
Disease 69 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the results reported by Adewuyi, 8 where undergraduates had markedly deficient knowledge regarding the mode of transmission of SCD, the undergraduates in our study had a good knowledge regarding the disease.
Gene_expression (transmission) of SCD associated with sickle cell anemia and disease
1) Confidence 0.57 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2931779 Disease Relevance 0.46 Pain Relevance 0
In general, females showed better knowledge of SCD, especially the nature of the disease, the mode of inheritance, its diagnosis, whether they personally had it or not, the difference between SCD and sickle cell trait, and the common symptoms and management.
Gene_expression (knowledge) of SCD associated with sickle cell anemia, sickle cell trait and disease
2) Confidence 0.57 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2931779 Disease Relevance 0.48 Pain Relevance 0
Because delta-9-THC is known to produce both excitatory and depressant effects in conscious animals, the results of the present study demonstrate that the choice of anesthetic may determine which effects manifest themselves.
Gene_expression (produce) of delta-9-THC
3) Confidence 0.56 Published 1983 Journal Life Sci. Section Abstract Doc Link 6300596 Disease Relevance 0.10 Pain Relevance 0.25
Because of low TRC8 expression in the tumor, we anticipated that SREBP target genes, including HMGCR and SCD1 might be overexpressed.
Gene_expression (overexpressed) of SCD1 associated with cancer
4) Confidence 0.53 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.68 Pain Relevance 0
We also analyzed the expression of HMGCR and SCD1, two SREBP target genes potentially down-regulated by TRC8 in RCC cells, and of the housekeeping gene PGK (Fig. 7A).
Spec (analyzed) Gene_expression (expression) of SCD1 associated with renal cancer
5) Confidence 0.53 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.73 Pain Relevance 0
The phenotypic expression of sickle cell disease (SCD) varies greatly among patients and longitudinally in the same patient.
Gene_expression (expression) of SCD associated with sickle cell anemia
6) Confidence 0.52 Published 2001 Journal Semin. Hematol. Section Abstract Doc Link 11605165 Disease Relevance 0.62 Pain Relevance 0.13
In contrast, we observed that SCD1 was strongly underexpressed while HMGCR was not affected in the dysgerminoma compared to normal ovary.
Gene_expression (underexpressed) of SCD1 in ovary associated with dysgerminoma
7) Confidence 0.46 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.68 Pain Relevance 0
Depression, loneliness and SCD
Gene_expression (Depression) of SCD associated with sickle cell anemia and depression
8) Confidence 0.40 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2894759 Disease Relevance 1.29 Pain Relevance 0.38
Pentobarbital inhibited withdrawal only at doses that produced ataxia. 1-(-)-delta9-THC had a biphasic effect on locomotor activity of guinea pig in the dose range that inhibited withdrawal, stimulation at 1 mg/kg and depression at 3 to 10 mg/kg.
Gene_expression (produced) of delta9-THC associated with ataxia, depression, eae and withdrawal
9) Confidence 0.34 Published 1976 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 988178 Disease Relevance 0.26 Pain Relevance 1.36
Treatment advances have now transformed SCD into a chronic disease suffered by children and adults.
Gene_expression (transformed) of SCD associated with sickle cell anemia and chronic disease
10) Confidence 0.33 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1253526 Disease Relevance 1.58 Pain Relevance 0.10
Evaluation of AHR with methacholine challenge in patients with SCD appears to be well tolerated and may elucidate a cause of SCD morbidity.
Gene_expression (Evaluation) of SCD associated with sickle cell anemia
11) Confidence 0.22 Published 2008 Journal Pediatr. Pulmonol. Section Abstract Doc Link 18671275 Disease Relevance 1.01 Pain Relevance 0.19
Determination of plasma and urine levels of Delta9-tetrahydrocannabinol and its main metabolite by liquid chromatography after solid-phase extraction.
Gene_expression (levels) of Delta9-tetrahydrocannabinol in urine
12) Confidence 0.20 Published 2008 Journal J Pharm Biomed Anal Section Title Doc Link 18242913 Disease Relevance 0.09 Pain Relevance 0.12
Recently, a larger cohort study consisting of 836 patients who underwent TWA testing (2.7±5.4 months after the onset of the MI) revealed that TWA predicted SCD or resuscitated ventricular fibrillation (VF) [43].
Gene_expression (predicted) of SCD associated with arrhythmias 2 under development and myocardial infarction
13) Confidence 0.19 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.83 Pain Relevance 0
In the prediction of SCD, TWA can be used as a screening test of appropriate patients for further electrophysiological examination and therapy.



Gene_expression (prediction) of SCD associated with myocardial infarction
14) Confidence 0.19 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Abstract Doc Link PMC1513519 Disease Relevance 1.07 Pain Relevance 0
However, only around 60% delta9-THC responses occurred in the 5.6 mg/kg delta9-THC training dose condition in tests with 18 mg/kg (R)-methanandamide; a higher dose (30 mg/kg) produced even fewer delta9-THC-appropriate responses in this group.
Gene_expression (produced) of delta9-THC-appropriate
15) Confidence 0.16 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888629 Disease Relevance 0 Pain Relevance 0.19
-thalassemia, SCD and MDS.78–81 In one study, 97% of patients with ?
Gene_expression (thalassemia) of SCD associated with sickle cell anemia, thalassemia and myelodysplastic syndromes
16) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773754 Disease Relevance 0.62 Pain Relevance 0
System SA exhibits the highest overall order (average SCD = ?
Gene_expression (overall) of SCD
17) Confidence 0.09 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1808021 Disease Relevance 0 Pain Relevance 0
System SA exhibits the highest overall order (average SCD = ?
Gene_expression (exhibits) of SCD
18) Confidence 0.09 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1808021 Disease Relevance 0 Pain Relevance 0
System SA exhibits the highest overall order (average SCD = ?
Gene_expression (average) of SCD
19) Confidence 0.09 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1808021 Disease Relevance 0 Pain Relevance 0
System SB is slightly less ordered (SCD = ?
Gene_expression (ordered) of SCD
20) Confidence 0.09 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1808021 Disease Relevance 0 Pain Relevance 0

General Comments

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