INT39153

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 182
Total Number 186
Disease Relevance 96.16
Pain Relevance 60.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
macrophages 3
PGE2 3
brain 3
head 3
epithelial cells 3
PTGS2 (Homo sapiens)
PTGS2 - R106E (1) PTGS2 - S516M (1)
Pain Link Frequency Relevance Heat
Inflammation 882 100.00 Very High Very High Very High
cytokine 401 100.00 Very High Very High Very High
cINOD 393 100.00 Very High Very High Very High
COX2 169 100.00 Very High Very High Very High
aspirin 148 100.00 Very High Very High Very High
metalloproteinase 69 100.00 Very High Very High Very High
cOX1 32 100.00 Very High Very High Very High
Potency 21 100.00 Very High Very High Very High
dexamethasone 29 99.98 Very High Very High Very High
chemokine 33 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1134 100.00 Very High Very High Very High
Chronic Hepatitis 3 100.00 Very High Very High Very High
Diabetes Mellitus 52 99.98 Very High Very High Very High
Herpes Virus Infection 6 99.98 Very High Very High Very High
Mouth Disease 49 99.96 Very High Very High Very High
Cancer 739 99.92 Very High Very High Very High
Multiple Myeloma 2 99.92 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.84 Very High Very High Very High
Hypoxia 21 99.84 Very High Very High Very High
Colorectal Cancer 1 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether similar elevations of PGHS-2 occur as part of the gliosis in AD, we quantified PGHS-2 mRNA levels in control and AD brain by Northern hybridization analysis.
Spec (whether) Positive_regulation (elevations) of PGHS-2 in brain associated with disease and gliosis
1) Confidence 0.70 Published 1996 Journal Neurobiol. Aging Section Abstract Doc Link 8892355 Disease Relevance 1.03 Pain Relevance 0.21
To determine whether the increased prostaglandin production is due to enhanced expression of PHS-2 and whether the up-regulation of PHS-2 has any correlation to histopathological findings in brain tumors, we evaluated the profile of PHS expression in several human glioma cell lines and surgical specimens from patients with various types of brain tumors.
Spec (whether) Positive_regulation (regulation) of PHS-2 in brain associated with glioma and brain tumor
2) Confidence 0.70 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11563634 Disease Relevance 1.15 Pain Relevance 0.18
Stimulation with STZ caused a time-dependent increase in levels of PGHS-2 mRNA; incubation with cytokine-suppressive agents caused a decrease of these levels, suggesting the involvement of transcription and/or mRNA stability events in the inhibition of PGHS-2.
Positive_regulation (increase) of PGHS-2 associated with cytokine
3) Confidence 0.69 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.07 Pain Relevance 0.23
[Safety of selective inhibitors of inducible cyclooxygenase-2 taken for a long period].
Positive_regulation (inducible) of cyclooxygenase-2 associated with cox2
4) Confidence 0.68 Published 2004 Journal Bull Cancer Section Title Doc Link 15239340 Disease Relevance 0.70 Pain Relevance 0.29
When blood is incubated with 0.01-10 micrograms/ml E. colilipopolysaccharide (LPS), PGHS-2 is induced and TxB2 levels become detectable at 3h and continue to increase through 24h.
Positive_regulation (induced) of PGHS-2 in blood
5) Confidence 0.65 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.09 Pain Relevance 0.33
Early indications are that selective inhibitors of the inducible cyclooxygenase-2 enzyme have little or no effect in causing ulcers.
Positive_regulation (inducible) of cyclooxygenase-2 enzyme associated with ulcers
6) Confidence 0.65 Published 2000 Journal Baillieres Best Pract Res Clin Gastroenterol Section Abstract Doc Link 10749097 Disease Relevance 0.87 Pain Relevance 0.48
In contrast, PTGS1 is constitutively expressed and its implication in CRC risk has not been investigated very much, since its carcinogenetic role through induction of PTGS2 has been suggested only recently [16,34].
Positive_regulation (induction) of PTGS2 associated with colon cancer
7) Confidence 0.60 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.77 Pain Relevance 0.08
This may be the result of activation of cyclooxygenase-2 (COX-2) in response to mitogens and growth factors, for example, which will result in an increased production of prostaglandins.
Positive_regulation (activation) of cyclooxygenase-2
8) Confidence 0.59 Published 2001 Journal Am. J. Med. Section Abstract Doc Link 11166002 Disease Relevance 0.68 Pain Relevance 0.67
As observed for the cyclooxygenase activity of PGHS-2, the inhibition of 15-HETE production by indomethacin was time-dependent for both ASA-PGHS-2 and PGHS-2(S516M).
Positive_regulation (dependent) of ASA-PGHS-2 associated with aspirin
9) Confidence 0.55 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.17 Pain Relevance 1.01
Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia after selective blockade of cyclooxygenase 2 in the preoperative period.
Positive_regulation (induction) of Cyclooxygenase-2 associated with cox2, cox1 and analgesia
10) Confidence 0.51 Published 2006 Journal Anesthesiology Section Title Doc Link 16394701 Disease Relevance 0.26 Pain Relevance 0.50
At the end of observation, cyclooxygenase-1 mRNA expression was unchanged, whereas cyclooxygenase-2 mRNA was significantly induced.
Positive_regulation (induced) of cyclooxygenase-2 mRNA
11) Confidence 0.51 Published 2006 Journal Anesthesiology Section Body Doc Link 16394701 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: In T cells, cyclooxygenase-1 is constitutively expressed, and cyclooxygenase-2 is induced during activation but their functions are not well known.
Positive_regulation (induced) of cyclooxygenase-2 in T cells
12) Confidence 0.50 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12102475 Disease Relevance 0.14 Pain Relevance 0.19
In vitro enzyme results were supported by a human whole blood assay where etodolac also demonstrated a 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production.
Positive_regulation (mediated) of PGHS-2 in blood
13) Confidence 0.50 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566109 Disease Relevance 0.08 Pain Relevance 0.34
Cyclooxygenase-2 (COX-2) is up-regulated in 85-90% of primary human colorectal cancers and is a putative target for the chemopreventative activity of non-steroidal anti-inflammatory drugs.
Positive_regulation (up-regulated) of Cyclooxygenase-2 associated with inflammation, colon cancer and cinod
14) Confidence 0.49 Published 2000 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11206834 Disease Relevance 0.65 Pain Relevance 0.10
A comprehensive meta-analysis of randomized trials indicated that cyclooxygenase-2 inhibitors increased the risk of vascular events by 42%, almost exclusively myocardial infarction, as did high-dose regimens of ibuprofen and diclofenac, but not naproxen.
Positive_regulation (increased) of cyclooxygenase-2 associated with diclofenac and myocardial infarction
15) Confidence 0.49 Published 2008 Journal J. Cardiovasc. Pharmacol. Ther. Section Abstract Doc Link 18287589 Disease Relevance 0.79 Pain Relevance 0.45
Cyclooxygenase-2 (COX-2) is up-regulated in stromal and inflammatory cells.
Positive_regulation (up-regulated) of Cyclooxygenase-2 associated with inflammation
16) Confidence 0.49 Published 2004 Journal Inflammation Section Abstract Doc Link 16134002 Disease Relevance 0.70 Pain Relevance 0.42
Hemicrania continua responds to cyclooxygenase-2 inhibitors.
Positive_regulation (responds) of cyclooxygenase-2 associated with headache
17) Confidence 0.49 Published 2002 Journal Headache Section Title Doc Link 12167145 Disease Relevance 0.30 Pain Relevance 0.39
BACKGROUND: Current guidelines recommend that patients at risk for ulcer disease who require treatment for arthritis receive nonsteroidal antiinflammatory drugs (NSAIDs) that are selective for cyclooxygenase-2 or the combination of a nonselective NSAID with a proton-pump inhibitor.
Positive_regulation (selective) of cyclooxygenase-2 associated with inflammation, ulcers, cinod, disease and arthritis
18) Confidence 0.49 Published 2002 Journal N. Engl. J. Med. Section Abstract Doc Link 12501222 Disease Relevance 0.62 Pain Relevance 0.37
Since up-regulation of COX-2 has been reported in different stages of the esophageal and gastric carcinogenic sequence, the cyclooxygenase-2 selective inhibitors (COXIBs) were considered a good alternative to traditional NSAIDs since they cause less injury to the gastrointestinal mucosa.
Positive_regulation (up-regulation) of cyclooxygenase-2 associated with injury and cinod
19) Confidence 0.49 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17691999 Disease Relevance 0.43 Pain Relevance 0.32
Induction of PGHS-2 occurs through an increase in PGHS-2 gene transcription.
Positive_regulation (Induction) of PGHS-2
20) Confidence 0.48 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.15 Pain Relevance 0.18

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