INT39170

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 76
Total Number 82
Disease Relevance 24.11
Pain Relevance 8.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
fat 3
brain 2
body 2
T cells 2
capsule 1
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 39 100.00 Very High Very High Very High
antagonist 15 99.96 Very High Very High Very High
Analgesic 30 99.64 Very High Very High Very High
diclofenac 220 99.52 Very High Very High Very High
gABA 6 99.16 Very High Very High Very High
cINOD 66 99.04 Very High Very High Very High
Paracetamol 35 99.02 Very High Very High Very High
carbamazepine 40 98.68 Very High Very High Very High
Infliximab 69 98.64 Very High Very High Very High
Etanercept 84 98.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bladder Disease 170 100.00 Very High Very High Very High
Focal Cartilage Defect 140 99.68 Very High Very High Very High
Liver Cancer 3 99.08 Very High Very High Very High
Breast Cancer 118 98.88 Very High Very High Very High
Pressure And Volume Under Development 98 98.88 Very High Very High Very High
INFLAMMATION 470 98.84 Very High Very High Very High
Convulsion 1 98.84 Very High Very High Very High
Partial Seizures 1 98.80 Very High Very High Very High
Adhesions 104 98.68 Very High Very High Very High
Apoptosis 567 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peripheral-type benzodiazepine receptor (PBR) is not only widely expressed throughout the body, but it is also genetically conserved from bacteria to humans.
Gene_expression (expressed) of PBR in body
1) Confidence 0.78 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9488670 Disease Relevance 0.28 Pain Relevance 0.07
PBR expression (cytofluorimetric evaluation) on peripheral blood mononuclear cells was also investigated in the 2 phases.
Spec (investigated) Gene_expression (expression) of PBR in blood
2) Confidence 0.75 Published 2007 Journal Clin J Pain Section Body Doc Link 17575492 Disease Relevance 0.18 Pain Relevance 0
In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has been discovered.
Gene_expression (expression) of PBR associated with gaba
3) Confidence 0.71 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.27 Pain Relevance 0.44
The peripheral-type benzodiazepine receptor (PBR) is not only widely expressed throughout the body, but it is also genetically conserved from bacteria to humans.
Gene_expression (expressed) of peripheral-type benzodiazepine receptor in body
4) Confidence 0.68 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9488670 Disease Relevance 0.28 Pain Relevance 0.07
Critics noted that by neglecting to inform the public that pharmaceutical marketing and inappropriate prescribing habits of doctors also produced pressures on the PBS, the campaign missed an opportunity to initiate a more balanced and constructive debate about the viability of the PBS [10].
Gene_expression (produced) of PBS
5) Confidence 0.67 Published 2005 Journal Aust New Zealand Health Policy Section Body Doc Link PMC548296 Disease Relevance 0.07 Pain Relevance 0
After the samples were washed with PBS-T, anti-CHIKV IgG was added (1:10,000) and the plates were incubated at 37°C for 60 min.
Gene_expression (washed) of PBS
6) Confidence 0.65 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2927496 Disease Relevance 0.21 Pain Relevance 0
The following day, the plates were washed with PBS and horseradish peroxidase (HRP)-conjugated rabbit anti-human IgG (1:10,000) was then added to the plates.
Gene_expression (washed) of PBS
7) Confidence 0.65 Published 2004 Journal BMC Neurol Section Body Doc Link PMC529262 Disease Relevance 0.47 Pain Relevance 0
Cells were thawed on ice, washed twice with PBS, resuspended in fluorescence-activated cell sorting (FACS)-blocking buffer (1% bovine serum albumin in PBS containing anti-CD16/CD32 antibody, Pharmingen/BD Bioscience, San Diego, USA) and incubated for 15 min at 4°C.
Gene_expression (containing) of PBS
8) Confidence 0.65 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2569845 Disease Relevance 0.12 Pain Relevance 0.06
Cells were washed twice with PBS, re-suspended in PBS (5 × 106 cells/ml) and subjected to sterile sorting by FACS Vantage (Becton Dickinson Immunocytometry Systems, Bedford, MA, USA).
Gene_expression (washed) of PBS
9) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0
Sections were then washed repeatedly in PBS/Sap.
Gene_expression (washed) of PBS
10) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206344 Disease Relevance 0 Pain Relevance 0
Cells were decidualized in vitro for 36 h, washed twice with PBS, transfected with duplexes (5 nM) and incubated in RPMI supplemented with 10% FCS for a further 24 h.
Gene_expression (washed) of PBS
11) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Following treatment for seven days with diazepam (2.0 mg/kg i.m., b.i.d.), administration of the benzodiazepine receptor antagonist RO 15-1788 (5 mg/kg) induced a severe withdrawal syndrome in vervet monkeys which included tremors, vomiting, vocalizations, chewing, and piloerection.
Gene_expression (administration) of benzodiazepine receptor associated with tremor, antagonist, vomiting and withdrawal
12) Confidence 0.61 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3920054 Disease Relevance 0.29 Pain Relevance 0.21
The MBR was operated in parallel with the CAS process (aeration tank and secondary settling tank).
Gene_expression (operated) of MBR
13) Confidence 0.61 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0 Pain Relevance 0
The reforms trialed in Victoria allowed public hospital doctors to write PBS prescriptions for both outpatients and discharged inpatients.
Gene_expression (prescriptions) of PBS
14) Confidence 0.58 Published 2005 Journal Aust New Zealand Health Policy Section Body Doc Link PMC548296 Disease Relevance 0.17 Pain Relevance 0
1 in the MBR effluent, compared with 48.41 ?
Gene_expression (effluent) of MBR
15) Confidence 0.53 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.07 Pain Relevance 0.11
-blockers atenolol (d) and metoprolol (e), the anti-ulcer agent ranitidine (f), the antiepileptic drug carbamazepine (g), and the psychiatric drug paroxetine (h)Fig. 3Removal during MBR and CAS treatment of the lipid regulator and cholesterol-lowering statin drugs gemfibrozil (a), bezafibrate (b), clofibric acid (c), and pravastatin (d), the diuretic hydrochlorothiazide (e), and the hypoglycaemic agent glibenclamide (f)
Gene_expression (treatment) of MBR associated with ulcers and carbamazepine
16) Confidence 0.53 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.25 Pain Relevance 0.60
Fig. 1Removal, during MBR and CAS treatment, of the analgesics and anti-inflammatory drugs naproxen (a), ketoprofen (b), ibuprofen (c), mefenamic acid (d), diclofenac (e), indomethacin (f), acetaminophen (g), and propyphenazone (h)Fig. 2Removal during MBR and CAS treatment of the antibiotics ofloxacin (a), sulfamethoxazole (b), and erythromycin (c), the ?
Gene_expression (treatment) of MBR associated with paracetamol, inflammation, analgesic, cinod and diclofenac
17) Confidence 0.53 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.17 Pain Relevance 0.37
Fig. 1Removal, during MBR and CAS treatment, of the analgesics and anti-inflammatory drugs naproxen (a), ketoprofen (b), ibuprofen (c), mefenamic acid (d), diclofenac (e), indomethacin (f), acetaminophen (g), and propyphenazone (h)Fig. 2Removal during MBR and CAS treatment of the antibiotics ofloxacin (a), sulfamethoxazole (b), and erythromycin (c), the ?
Gene_expression (treatment) of MBR associated with paracetamol, inflammation, analgesic, cinod and diclofenac
18) Confidence 0.53 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0.24 Pain Relevance 0.49
Australia's senior negotiator on the AUSFTA PBS provisions, likewise stated:
Gene_expression (provisions) of PBS
19) Confidence 0.47 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0 Pain Relevance 0
There are also obligations acquired under the AUSTFA requiring 'valuing' of pharmaceutical "innovation" through either the operation of "competitive markets" (the US position, requiring an enhanced role for competition and anti-trust regulators) or "objectively demonstrated therapeutic significance" (the Australian position, supporting an enhanced role for the PBAC in ensuring that the PBS expenditure on new PBS-listed products is commensurate with evidence-based assessments of their comparative community value and cost of development) (Annex 2C.1)[89].
Gene_expression (expenditure) of PBS
20) Confidence 0.47 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0 Pain Relevance 0

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