INT39188

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Context Info
Confidence 0.38
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 10.95
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 4
Blood 1
astrocytes 1
immune system 1
HOS 1
IGKV5-2 (Homo sapiens)
Pain Link Frequency Relevance Heat
B1 receptor 122 99.80 Very High Very High Very High
Pain 218 99.70 Very High Very High Very High
acular 147 99.68 Very High Very High Very High
Serotonin 12 99.64 Very High Very High Very High
bradykinin 512 99.52 Very High Very High Very High
Eae 99 98.88 Very High Very High Very High
Paracetamol 12 98.88 Very High Very High Very High
agonist 49 98.08 Very High Very High Very High
b2 receptor 77 97.00 Very High Very High Very High
nociceptor 28 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 26 99.84 Very High Very High Very High
Pain 231 99.70 Very High Very High Very High
Osteogenic Sarcomas 2 99.44 Very High Very High Very High
Injury 227 98.94 Very High Very High Very High
Inflammatory Pain 91 98.88 Very High Very High Very High
Cancer 8 98.56 Very High Very High Very High
Cystitis 102 98.38 Very High Very High Very High
Pyuria 15 97.90 Very High Very High Very High
INFLAMMATION 151 95.20 Very High Very High Very High
Hyperalgesia 14 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.
Gene_expression (synthesis) of B2 in platelet associated with paracetamol
1) Confidence 0.38 Published 1985 Journal Thromb. Res. Section Title Doc Link 3923647 Disease Relevance 0 Pain Relevance 0.41
We examined the effect of acetaminophen and the structural analogues 2,6-dimethylacetaminophen, 3,5-dimethylacetaminophen, and N-acetyl-p-benzoquinone imine on human platelet aggregation, 14C-serotonin secretion, and thromboxane B2 synthesis.
Gene_expression (synthesis) of B2 in platelet associated with paracetamol and serotonin
2) Confidence 0.38 Published 1985 Journal Thromb. Res. Section Abstract Doc Link 3923647 Disease Relevance 0 Pain Relevance 0.36
Thromboxane B2 production and 14C-serotonin secretion by arachidonic acid-stimulated platelets also were completely inhibited.
Gene_expression (production) of B2 in platelets associated with serotonin
3) Confidence 0.38 Published 1985 Journal Thromb. Res. Section Abstract Doc Link 3923647 Disease Relevance 0 Pain Relevance 0.38
Preincubation of platelets with 1 mM 3,5-dimethylacetaminophen inhibited collagen and arachidonic acid-induced aggregation and arachidonic acid-stimulated thromboxane B2 synthesis, while treatment with 2,6-dimethylacetaminophen did not inhibit aggregation and blocked thromboxane B2 formation to a much lesser degree.
Gene_expression (synthesis) of B2 in platelets
4) Confidence 0.38 Published 1985 Journal Thromb. Res. Section Abstract Doc Link 3923647 Disease Relevance 0 Pain Relevance 0.36
The expression of genes coding kininogen, B1 and B2 receptors can be a very sensitive marker of tissue pathology.
Gene_expression (expression) of B2
5) Confidence 0.31 Published 2001 Journal Ginekol. Pol. Section Abstract Doc Link 11757483 Disease Relevance 0.18 Pain Relevance 0.26
CONCLUSIONS: The absence of kininogen and B2 mRNA expression characterised vulvar cancer tissue.
Gene_expression (expression) of B2
6) Confidence 0.27 Published 2001 Journal Ginekol. Pol. Section Body Doc Link 11757483 Disease Relevance 0 Pain Relevance 0
DESIGN: In the present study, the analysis of expression of genes coding kininogen, B1 and B2 was performed.
Gene_expression (expression) of B2
7) Confidence 0.24 Published 2001 Journal Ginekol. Pol. Section Body Doc Link 11757483 Disease Relevance 0 Pain Relevance 0
BK receptors B1 (B1R) and B2 (B2R) were expressed in SaM-1 and osteosarcoma (SaOS-2, HOS, and MG-63) cells.
Gene_expression (expressed) of B2 in MG-63 associated with osteogenic sarcomas and bradykinin
8) Confidence 0.20 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.25 Pain Relevance 0.49
The correlation we show here between the gene expression of B2 and B1 receptor supports this mechanism in the present clinical model of tissue injury.
Gene_expression (expression) of B2 associated with b1 receptor and injury
9) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.85 Pain Relevance 0.76
The absence of significant correlation between B2 and TRPV1 gene expression could possibly reflect the dissociation between gene expression levels and the functionality of B2 receptors due to the constitutive nature of B2 receptors and their rapid desensitization.
Gene_expression (expression) of B2
10) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.62 Pain Relevance 0.70
This might explain the correlation between pain intensity and B2 receptors expression in the ketorolac treatment group but not in the placebo treatment group.
Gene_expression (expression) of B2 associated with pain and acular
11) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.87 Pain Relevance 1.14
B2 receptors are constitutively expressed but undergo extensive desensitization by their agonists.
Gene_expression (expressed) of B2 associated with agonist
12) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.67 Pain Relevance 1.04
Interestingly, the up-regulation in the gene expression of B1 and B2 receptors was positively correlated to pain intensity only after ketorolac treatment, signifying an interaction between prostaglandins and kinins in the inflammatory pain process.
Gene_expression (expression) of B2 associated with pain, eae and acular
13) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.26 Pain Relevance 0.87
Tissue injury resulted in a significant up-regulation in the gene expression of B1 and B2 receptors at 3 hours post-surgery, the onset of acute inflammatory pain.
Gene_expression (expression) of B2 associated with eae and injury
14) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.22 Pain Relevance 0.86
Further, the gene expression of both B1 and B2 receptors were correlated.
Gene_expression (expression) of B2
15) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.20 Pain Relevance 0.95
B2 receptors are highly expressed on glioma cells, and the expression of these receptors may be correlated with tumor grade [29], suggesting that they may play a role in the abnormal growth and migration of these cells [28].
Gene_expression (expressed) of B2 associated with cancer and glioma
16) Confidence 0.11 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.40 Pain Relevance 0.24
It has been reported that B2 receptors are more highly expressed in glioma cells as compared with normal astrocytes [28] and the level of expression of B2 receptors may be correlated with the grade of human gliomas [29].
Gene_expression (expressed) of B2 in astrocytes associated with glioma
17) Confidence 0.11 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.64 Pain Relevance 0.39
Blood was assayed for serum-generated thromboxane B2 synthesis (COX-1 assay) and for lipopolysaccharide-stimulated prostaglandin E2 synthesis (COX-2 assay).
Gene_expression (synthesis) of B2 in Blood
18) Confidence 0.08 Published 1998 Journal Am. J. Med. Section Body Doc Link 9626023 Disease Relevance 0.09 Pain Relevance 0
BK receptors B1 (B1R) and B2 (B2R) were expressed in SaM-1 and osteosarcoma (SaOS-2, HOS, and MG-63) cells.
Gene_expression (expressed) of B2 in HOS associated with osteogenic sarcomas and bradykinin
19) Confidence 0.07 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.25 Pain Relevance 0.49
CD97 is the only receptor in subfamily B2 for which the ligand has so far been identified, although there is evidence for the existence of a ligand for EMR3, another member of subfamily B2 expressed in the immune system, on human macrophages and activated neutrophils [27].
Gene_expression (expressed) of B2 in immune system
20) Confidence 0.05 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0 Pain Relevance 0

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