INT3919

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Context Info
Confidence 0.71
First Reported 1977
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 2.95
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 5
blood 2
plasma 1
tubes 1
hearts 1
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
Bile 2 99.98 Very High Very High Very High
Potency 3 98.92 Very High Very High Very High
halothane 62 94.64 High High
Paracetamol 138 93.80 High High
ketamine 1 82.84 Quite High
ischemia 59 79.00 Quite High
alcohol 27 75.28 Quite High
Inflammation 21 70.08 Quite High
cINOD 2 62.12 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 40 100.00 Very High Very High Very High
Gallstones 2 99.84 Very High Very High Very High
Injury 73 98.68 Very High Very High Very High
Decapitation 2 96.20 Very High Very High Very High
Necrosis 23 92.00 High High
Overdose 7 86.76 High High
Body Weight 13 86.00 High High
Parkinson's Disease 2 83.96 Quite High
Cv Unclassified Under Development 43 79.00 Quite High
Liver Disease 5 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twenty-three chemicals, differing widely in cytotoxic (hepatotoxic) potency in vivo, were examined to determine their ability to release glutamic-oxaloacetic transaminase (GOT) from hepatocytes isolated by a nonperfusion method from rat liver.
Localization (release) of GOT in liver associated with potency
1) Confidence 0.71 Published 1980 Journal J Toxicol Environ Health Section Abstract Doc Link 6991712 Disease Relevance 0.05 Pain Relevance 0.24
Twenty-three chemicals, differing widely in cytotoxic (hepatotoxic) potency in vivo, were examined to determine their ability to release glutamic-oxaloacetic transaminase (GOT) from hepatocytes isolated by a nonperfusion method from rat liver.
Localization (release) of transaminase in liver associated with potency
2) Confidence 0.62 Published 1980 Journal J Toxicol Environ Health Section Abstract Doc Link 6991712 Disease Relevance 0.05 Pain Relevance 0.24
The severity of the cardiac injury produced was assessed by visual inspection, determination of the release of LDH, CPK, GOT, and HBDH from isolated perfused hearts, and measurement of cardiac uptake of technetium-99m-methylene diphosphonate in vivo.
Localization (release) of GOT in hearts associated with injury
3) Confidence 0.59 Published 1977 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 918349 Disease Relevance 0.34 Pain Relevance 0
Measurement of plasma GPT and GOT
Localization (Measurement) of GOT in plasma
4) Confidence 0.44 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.17 Pain Relevance 0.29
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Localization (secretion) of transaminase in liver associated with glutamate, bile and hepatotoxicity
5) Confidence 0.39 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.64
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Localization (release) of transaminase in liver associated with glutamate, bile and hepatotoxicity
6) Confidence 0.34 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.64
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of glutamic oxaloacetic acid transaminase in blood
7) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of GOT in blood
8) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
Supernatants were transferred into fresh tubes for evaluation of concentration of glutamic-oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), the ratio of AST compare ALT (S/L), total protein (TP), albumin (ALB), globulin (GLB), the ratio of ALB compare GLB (A/G), phosphocreatine kinase (CK), lactate dehydrogenase (LDH), urea nitrogen (BUN) and creatinine (CRE) through automatic biochemistry analyzer(abbott, USA).


Localization (oxaloacetic) of transaminase in tubes
9) Confidence 0.18 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.23 Pain Relevance 0.04
A conventional dose of naproxen similarly prevented transaminase release.
Localization (release) of transaminase
10) Confidence 0.18 Published 1997 Journal J Drug Target Section Abstract Doc Link 9169987 Disease Relevance 0.53 Pain Relevance 0.16
Transaminase release
Localization (release) of Transaminase
11) Confidence 0.08 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1090549 Disease Relevance 0.21 Pain Relevance 0.12
The plasma fractions were analyzed for indices of liver damage (alanine transaminase, aspartate transaminase, lactate dehydrogenase), levels of malondialdehyde (MDA), reduced (GSH) and oxidized (GSSG) glutathione, and activities of glutathione reductase (GR), glutathione S-transferase (GST) and ?
Localization (damage) of aspartate transaminase in liver associated with hepatotoxicity
12) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.47 Pain Relevance 0.92

General Comments

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