INT39198

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Context Info
Confidence 0.52
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.35
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
liver 1
spinal cord 1
kidney 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 94.76 High High
alcohol 1 91.84 High High
Paracetamol 4 88.68 High High
anticonvulsant 2 88.48 High High
Inflammation 2 67.28 Quite High
Pain 2 65.84 Quite High
agonist 1 52.08 Quite High
antagonist 3 51.04 Quite High
Spinal cord 2 50.00 Quite Low
vincristine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 96.48 Very High Very High Very High
Toxicity 24 96.24 Very High Very High Very High
Sprains And Strains 2 95.48 Very High Very High Very High
Congenital Anomalies 8 89.08 High High
Acute-phase Reaction 2 75.00 Quite High
Obesity 2 72.76 Quite High
INFLAMMATION 1 67.28 Quite High
Pain 4 65.84 Quite High
Frailty 2 65.80 Quite High
Neuropathic Pain 1 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Negative_regulation (decrease) of UGT1A1 in kidney
1) Confidence 0.52 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
Immunohistochemistry was used to localize the B1 and TRPV-1 receptors within the spinal cord.
Negative_regulation (localize) of B1 in spinal cord
2) Confidence 0.43 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0.13 Pain Relevance 0
In Gunn rats, we showed that substitution of the phenolic aglycone by bulky (alkyl- or methoxy-) groups in the 2-position of the phenolic ring decreased UDPGT (GT1) activity, whereas substitution in the 4-position resulted in an increase in this activity.
Negative_regulation (decreased) of UDPGT
3) Confidence 0.35 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3925953 Disease Relevance 0.09 Pain Relevance 0.10
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Negative_regulation (decrease) of UGT1A1 in liver
4) Confidence 0.18 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes.
Negative_regulation (deficient) of B1 associated with targeted disruption and sprains and strains
5) Confidence 0.17 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497143 Disease Relevance 0.41 Pain Relevance 0.15
CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy.
Negative_regulation (engaged) of B1
6) Confidence 0.14 Published 2009 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19300402 Disease Relevance 0.13 Pain Relevance 0
Of the few relevant pharmacokinetic interactions, the inhibition of the metabolising enzyme UGT1A1 by atazanavir might even be exploited therapeutically.
Negative_regulation (inhibition) of UGT1A1
7) Confidence 0.09 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761196 Disease Relevance 0.28 Pain Relevance 0
Indinavir and Atazanavir inhibit UGT1A1.
Negative_regulation (inhibit) of UGT1A1
8) Confidence 0.09 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761196 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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