INT39199

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.78
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
CAR 2
neuronal 1
liver 1
jejunum 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 7 100.00 Very High Very High Very High
dorsal root ganglion 1 99.92 Very High Very High Very High
agonist 6 99.50 Very High Very High Very High
Hyperalgesia 10 98.80 Very High Very High Very High
Inflammation 5 98.24 Very High Very High Very High
Calcitonin gene-related peptide 1 97.52 Very High Very High Very High
b2 receptor 5 97.36 Very High Very High Very High
antagonist 5 95.92 Very High Very High Very High
Paracetamol 15 95.48 Very High Very High Very High
Morphine 9 94.52 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 99.92 Very High Very High Very High
Hyperalgesia 11 98.80 Very High Very High Very High
INFLAMMATION 5 98.24 Very High Very High Very High
Nervous System Injury 3 97.56 Very High Very High Very High
Injury 1 91.52 High High
Sprains And Strains 1 88.96 High High
Hypersensitivity 2 87.88 High High
Neuropathic Pain 2 87.20 High High
Cancer 2 66.00 Quite High
Porphyria 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Five patients were homozygous for the UGT1A1 TA(7) allele, which is associated with reduced UGT1A1 gene expression.
Positive_regulation (homozygous) of UGT1A1
1) Confidence 0.45 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 12185559 Disease Relevance 0.07 Pain Relevance 0
Messenger RNA and protein levels of UGT1A1 and UGT1A6 in the liver but not the jejunum were increased in male rats fed the HF1 diet.
Positive_regulation (increased) of UGT1A1 in jejunum
2) Confidence 0.43 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.11
Additionally, administration of the PPARalpha agonist clofibrate to male rats up-regulated UGT1A1 and UGT1A6 and down-regulated CYP1A2 in the liver.
Positive_regulation (up-regulated) of UGT1A1 in liver associated with agonist
3) Confidence 0.43 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.30
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Positive_regulation (increase) of B1 associated with b1 receptor and b2 receptor
4) Confidence 0.43 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.53 Pain Relevance 1.11
B1 activation has an important role in the hyperalgesia associated with inflammation, but the site of action of B1 antagonists has generally been believed to be on peripheral, non-neuronal cells.
Positive_regulation (activation) of B1 in neuronal associated with hyperalgesia, inflammation and antagonist
5) Confidence 0.41 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11072143 Disease Relevance 0.30 Pain Relevance 0.62
Stably expressed human and rat phenol UDP-glucuronosyltransferases (UGTs) of the UGT1 complex (HlugP1, HlugP4 and 3-methylcholanthrene-inducible rat UGT1A1, the latter considered to be an orthologous enzyme to HlugP1) have been used to investigate the role of UGTs in paracetamol glucuronidation.
Positive_regulation (3-methylcholanthrene-inducible) of UGT1A1 associated with paracetamol
6) Confidence 0.35 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8494539 Disease Relevance 0 Pain Relevance 0.31
Induction of B1 receptors in vivo in a model of persistent inflammatory mechanical hyperalgesia in the rat.
Positive_regulation (Induction) of B1 associated with hyperalgesia and inflammation
7) Confidence 0.31 Published 1994 Journal Neuropharmacology Section Title Doc Link 8183437 Disease Relevance 0.80 Pain Relevance 1.06
Since CAR is associated with the induction of metabolic enzymes such as CYP2B, CYP3A, and UGT1A1, the circadian rhythmicity of CAR mRNA expression may be reflected in the diurnal-difference of PB-induction of CYP2B1/2 mRNA.
Positive_regulation (induction) of UGT1A1 in CAR
8) Confidence 0.29 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0
Recently, bilirubin was reported to be an endogenous activator of the CAR gene, which is in turn associated with the induction of bilirubin metabolising proteins, such as organic anion transporter SLC21A6, glutathione-S-transferase (GST), UGT1A1 and MRP2.
Positive_regulation (induction) of UGT1A1 in CAR
9) Confidence 0.29 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0.04
In guinea pigs, we confirmed that phenobarbital selectively increased the activities of UDPGT towards twenty monoterpenoid alcohols without affecting other typical phenobarbital-induced activities such as those for conjugation of morphine.
Positive_regulation (increased) of UDPGT associated with morphine
10) Confidence 0.28 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3925953 Disease Relevance 0.09 Pain Relevance 0.13

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