INT3920

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 241
Total Number 247
Disease Relevance 83.08
Pain Relevance 58.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
hepatocytes 19
microglia 15
hearts 13
liver 10
plasma 9
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 3201 100.00 Very High Very High Very High
Bile 6 99.98 Very High Very High Very High
lidocaine 55 99.92 Very High Very High Very High
Paracetamol 1038 99.84 Very High Very High Very High
cocaine 201 99.82 Very High Very High Very High
Catecholamine 5 99.60 Very High Very High Very High
aspirin 63 99.54 Very High Very High Very High
dexamethasone 4 99.52 Very High Very High Very High
Potency 341 99.50 Very High Very High Very High
antagonist 204 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 108 100.00 Very High Very High Very High
Infarction 20 100.00 Very High Very High Very High
Death 1875 99.96 Very High Very High Very High
Apoptosis 1870 99.92 Very High Very High Very High
Contracture 5 99.70 Very High Very High Very High
Injury 666 99.68 Very High Very High Very High
Shock 14 99.60 Very High Very High Very High
Hemolysis 1 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 136 99.42 Very High Very High Very High
Toxicity 398 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Volatile anesthetics also significantly attenuated LDH release during reperfusion.
Localization (release) of LDH
1) Confidence 0.81 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.11 Pain Relevance 0
The ischemia-reperfusion injury was assessed by LDH release from the perfused liver.
Localization (release) of LDH in liver
2) Confidence 0.81 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.16 Pain Relevance 0
The release of LDH and the rhythmic disturbances were also increased. 4.
Localization (release) of LDH
3) Confidence 0.81 Published 1983 Journal J Pharmacol Section Abstract Doc Link 6220181 Disease Relevance 0.40 Pain Relevance 0.31
These toxins also significantly increased LDH and/or gamma-GT release in HepG2 spheroids.
Localization (release) of LDH
4) Confidence 0.81 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12781628 Disease Relevance 0.07 Pain Relevance 0.20
In this model, SQ 32,547 was protective because it significantly reduced contracture formation and lactate dehydrogenase (LDH) release.
Localization (release) of lactate dehydrogenase associated with contracture
5) Confidence 0.81 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7475054 Disease Relevance 0.25 Pain Relevance 0.22
In this model, SQ 32,547 was protective because it significantly reduced contracture formation and lactate dehydrogenase (LDH) release.
Localization (release) of LDH associated with contracture
6) Confidence 0.81 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7475054 Disease Relevance 0.24 Pain Relevance 0.21
Ca++ antagonists, nonselective for slow Ca++ channels (flunarizine, cinnarizine, lidoflazine, prenylamine and bepridil) inhibited veratridine-induced release of LDH with IC50 values between 0.11 and 0.47 microM.
Localization (release) of LDH associated with antagonist
7) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.39
The neuronal cell degeneration was Ca+(+)-dependent because, in the absence of extracellular Ca++, 16 hr of exposure to 30 microM veratridine failed to produce release of LDH.
Localization (release) of LDH in neuronal
8) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.09 Pain Relevance 0.35
A good correlation was found between the potency of the drugs to inhibit released LDH induced by 30 microM veratridine in neuronal cultures and their binding affinity for the batrachotoxin binding site of Na+ channels in rat cortex synaptosomal preparation.
Localization (released) of LDH in cortex associated with potency
9) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.48
Tested local anesthetics were incomplete inhibitors of veratridine-induced release of LDH.
Localization (release) of LDH associated with local anesthetic
10) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.49
Cell death was quantified by measuring lactate dehydrogenase (LDH) released in the culture medium.
Localization (released) of lactate dehydrogenase associated with death
11) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.10 Pain Relevance 0.28
Cell death was quantified by measuring lactate dehydrogenase (LDH) released in the culture medium.
Localization (released) of LDH associated with death
12) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.10 Pain Relevance 0.28
Ca++ antagonists selective for slow Ca++ channels were less potent and inhibited veratridine-induced release of LDH at concentrations in the following order of potency: nicardipine greater than gallopamil and verapamil greater than niludipine greater than nitrendipine greater than nifedipine greater than nimodipine greater than diltiazem.
Localization (release) of LDH associated with antagonist and potency
13) Confidence 0.81 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.40
H2O2 (600 microM) increased the left ventricular end-diastolic pressure, decreased the tissue level of ATP, and increased the release of lactate dehydrogenase from the myocardium.
Localization (release) of lactate dehydrogenase in myocardium
14) Confidence 0.80 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422783 Disease Relevance 0 Pain Relevance 0.08
We found that intracellular LDH is a direct indicator of the number of viable hepatocytes in contrast to the LDH released, because released LDH does not account for the significant number of cells detached from monolayer but which are not leaky, during the 6-hr test period.
Localization (released) of LDH in hepatocytes
15) Confidence 0.80 Published 1988 Journal Cell Biol. Toxicol. Section Abstract Doc Link 3228704 Disease Relevance 0 Pain Relevance 0.16
We found that intracellular LDH is a direct indicator of the number of viable hepatocytes in contrast to the LDH released, because released LDH does not account for the significant number of cells detached from monolayer but which are not leaky, during the 6-hr test period.
Localization (released) of LDH in hepatocytes
16) Confidence 0.80 Published 1988 Journal Cell Biol. Toxicol. Section Abstract Doc Link 3228704 Disease Relevance 0 Pain Relevance 0.16
In searching for a reliable index for cytotoxicity testing in rat hepatocyte primary culture, lactate dehydrogenase (LDH) concentrations in lysates of attached hepatocytes and LDH released into the culture medium were compared under conditions of exposure to various dosages of sodium chloride, sodium salicylate, R-warfarin, acetaminophen, phenylbutazone, and furosemide (frusemide).
Localization (released) of LDH in hepatocyte associated with paracetamol
17) Confidence 0.80 Published 1988 Journal Cell Biol. Toxicol. Section Abstract Doc Link 3228704 Disease Relevance 0 Pain Relevance 0.09
Cell death was measured by release of lactate dehydrogenase (LDH).
Localization (release) of LDH associated with death
18) Confidence 0.80 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9294967 Disease Relevance 0.27 Pain Relevance 0.31
Cell death was measured by release of lactate dehydrogenase (LDH).
Localization (release) of lactate dehydrogenase associated with death
19) Confidence 0.80 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9294967 Disease Relevance 0.27 Pain Relevance 0.31
One hundred and twenty to 240 min of deprivation caused graded increases in glutamate overflow, LDH release and 45Ca influx.
Localization (release) of LDH associated with glutamate
20) Confidence 0.80 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9294967 Disease Relevance 0.26 Pain Relevance 0.34

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