INT39212

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 9.62
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Anatomy Link Frequency
skin 1
autonomic nervous system 1
bowel 1
duct 1
Ttr (Rattus norvegicus)
Ttr - L12P (1)
Pain Link Frequency Relevance Heat
peripheral neuropathy 4 99.76 Very High Very High Very High
carpal tunnel syndrome 6 98.84 Very High Very High Very High
Chronic pancreatitis 1 98.26 Very High Very High Very High
spastic colon 4 96.64 Very High Very High Very High
Inflammation 1 96.00 Very High Very High Very High
Bile 2 95.76 Very High Very High Very High
Peripheral nervous system 3 91.76 High High
Analgesic 6 89.92 High High
Sciatica 1 83.08 Quite High
cva 1 80.56 Quite High
Disease Link Frequency Relevance Heat
Amyloid Neuropathies 2 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 2 100.00 Very High Very High Very High
Multiple Myeloma 1 100.00 Very High Very High Very High
Solid Tumor 1 100.00 Very High Very High Very High
Renal Cell Carcinoma 1 100.00 Very High Very High Very High
Lymphatic System Cancer 1 100.00 Very High Very High Very High
Macroglobulinemia 1 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 8 99.98 Very High Very High Very High
Familial Amyloidosis 3 99.98 Very High Very High Very High
Peripheral Neuropathy 5 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structure-activity data show that many pharmacological agents are strong competitive inhibitors for thyroxine (T4) binding to transthyretin (TTR) and that this competition can interfere with their normal pharmacological actions.
transthyretin Binding (binding) of
1) Confidence 0.48 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0
Structure-activity data show that many pharmacological agents are strong competitive inhibitors for thyroxine (T4) binding to transthyretin (TTR) and that this competition can interfere with their normal pharmacological actions.
TTR Binding (binding) of
2) Confidence 0.48 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0.05
Crystallographic analyses of ligand co-crystal complexes of human and rat TTR have been studied to understand the molecular basis for binding selectivity of competitor binding to TTR.
TTR Binding (binding) of
3) Confidence 0.48 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0.09
Crystallographic analyses of ligand co-crystal complexes of human and rat TTR have been studied to understand the molecular basis for binding selectivity of competitor binding to TTR.
TTR Binding (complexes) of
4) Confidence 0.37 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0.08
Data for the human TTR complex with the bromoflavone EMD21388 incubated at different times revealed variable binding positions and occupancies dependent upon incubation time.
TTR Binding (complex) of
5) Confidence 0.37 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0.09
Comparison of the structures of T4 thyroacetic acid in complex with both human and rat TTR revealed forward and reverse binding, but also showed different modes of binding in the rat compared to the human complex.
TTR Binding (complex) of
6) Confidence 0.37 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553424 Disease Relevance 0 Pain Relevance 0.08
[Clinical and genetic heterogeneity in familial amyloidotic polyneuropathy associated with variant transthyretin].
transthyretin Binding (associated) of associated with familial amyloidotic polyneuropathy
7) Confidence 0.32 Published 1993 Journal Nippon Rinsho Section Title Doc Link 8411724 Disease Relevance 0.90 Pain Relevance 0.12
Comparing patients with pancreatic cancer, chronic pancreatitis or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer.
transthyretin Binding (associated) of in duct associated with pancreatic cancer, chronic pancreatitis and disorder of lipid metabolism
8) Confidence 0.16 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055369 Disease Relevance 1.19 Pain Relevance 0.19
Transthyretin (TTR) tetramer dissociation and misfolding affords a monomeric amyloidogenic intermediate that misassembles into aggregates including amyloid fibrils.
Transthyretin Binding (dissociation) of associated with alzheimer's dementia
9) Confidence 0.15 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 14968122 Disease Relevance 0.68 Pain Relevance 0.35
A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis.
transthyretin Binding (associated) of in skin associated with amyloidosis, carpal tunnel syndrome and peripheral neuropathy
10) Confidence 0.14 Published 2003 Journal Amyloid Section Title Doc Link 12762139 Disease Relevance 0.57 Pain Relevance 0.28
Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis.
Transthyretin (L12P) Binding (associated) of associated with amyloidosis and neuropathic pain
11) Confidence 0.12 Published 1999 Journal Brain Section Title Doc Link 10071047 Disease Relevance 1.27 Pain Relevance 0.27
[Hereditary amyloidoses associated with transthyretin mutations].
transthyretin Binding (associated) of associated with familial amyloidosis
12) Confidence 0.12 Published 2002 Journal Nervenarzt Section Title Doc Link 12376880 Disease Relevance 0.65 Pain Relevance 0.07
Our results suggest that diarrhea severity and co-medication were the only variables associated with TTR, considered in this trial as an indicator of acute childhood diarrhea evolution after racecadotril treatment.
TTR Binding (associated) of associated with diarrhoea
13) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909495 Disease Relevance 0.85 Pain Relevance 0
We performed a general linear model (UNIANOVA) to search potential associations among patient characteristics and TTR, considered a dependent variable in the model.
TTR Binding (associations) of
14) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909495 Disease Relevance 0.63 Pain Relevance 0
The peripheral nervous system can be involved in the following amyloid deposition diseases. (1) Amyloid deposition composed of beta 2-microglobulin in patients on long term hemodialysis causing a carpal tunnel syndrome; (2) deposition of light chain immunoglobulin derived amyloid leading to polyneuropathy, carpal tunnel syndrome and autonomic nervous system involvement in patients with primary amyloidosis, or amyloidosis secondary to or associated with multiple myeloma, Waldenström's macroglobulinemia, non-Hodgkin's lymphoma, and solid neoplasms like hypernephroma; and (3) several types of heredofamilial amyloid polyneuropathies, which are mainly caused by a point-mutation in the transthyretin gene on chromosome 18.
transthyretin gene Spec (like) Binding (associated) of in autonomic nervous system associated with alzheimer's dementia, renal cell carcinoma, multiple myeloma, disease, neuropathy, macroglobulinemia, lymphatic system cancer, peripheral nervous system, amyloidosis, amyloid neuropathies, carpal tunnel syndrome and solid tumor
15) Confidence 0.02 Published 1994 Journal Clin Neurol Neurosurg Section Abstract Doc Link 8187375 Disease Relevance 1.78 Pain Relevance 0.28
We assessed the nutritional status of 119 patients with chronic gastrointestinal symptoms due to organic disorders (inflammatory bowel disease, IBD; peptic ulcer, PU; malabsorption syndrome, M; and malignant gastrointestinal tumours, T), by standard anthropometry and marker proteins (albumin; retinol-binding protein, RBP; and thyroxine-binding prealbumin, TBPA).
prealbumin Binding (thyroxine-binding) of in bowel associated with malignant neoplastic disease, inflammatory bowel disease, inflammation, cancer, ulcers and malabsorption syndromes
16) Confidence 0.02 Published 1985 Journal Hum Nutr Clin Nutr Section Abstract Doc Link 3926730 Disease Relevance 0.89 Pain Relevance 0.35

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