INT3922

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2001
Negated 0
Speculated 2
Reported most in Abstract
Documents 29
Total Number 32
Disease Relevance 3.18
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
blood 3
plasma 2
neurons 2
nucleus 2
Medullas 1
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 74 99.38 Very High Very High Very High
depression 2 99.08 Very High Very High Very High
rheumatoid arthritis 8 98.84 Very High Very High Very High
noradrenaline 11 98.76 Very High Very High Very High
Enkephalin 7 98.72 Very High Very High Very High
Locus ceruleus 42 97.68 Very High Very High Very High
Catecholamine 19 96.80 Very High Very High Very High
antagonist 8 96.64 Very High Very High Very High
agonist 19 96.40 Very High Very High Very High
Hippocampus 2 94.16 High High
Disease Link Frequency Relevance Heat
Depression 4 99.08 Very High Very High Very High
Rheumatoid Arthritis 8 98.84 Very High Very High Very High
Decapitation 2 96.20 Very High Very High Very High
Cognitive Disorder 1 94.04 High High
Hypertension 12 93.76 High High
Heart Rate Under Development 8 90.40 High High
Urological Neuroanatomy 4 83.56 Quite High
Pressure Volume 2 Under Development 11 79.52 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitor of phenylethanolamine-N-methyl transferase (PNMT), SK&F 64139 (7, 8-dichloro-1, 2, 3, 4-tetrahydroisoquinoline), when given i.v. (5 mg/kg), did not prevent the decrease of blood pressure induced in conscious spontaneously hypertensive rats (SHR) by alpha-methyldopa (50 mg/kg i.v.).
Negative_regulation (inhibitor) of phenylethanolamine-N-methyl transferase in blood associated with hypertension
1) Confidence 0.59 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6132343 Disease Relevance 0.23 Pain Relevance 0.27
By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F 64139 and DCMB, drugs which are both potent inhibitors of the A-forming enzyme phenylethanolamine-N-methyltransferase (PNMT).
Negative_regulation (inhibitors) of phenylethanolamine-N-methyltransferase in neurons associated with locus ceruleus
2) Confidence 0.59 Published 1981 Journal Brain Res. Section Abstract Doc Link 7284809 Disease Relevance 0 Pain Relevance 0.46
The greater the amount of intraarticularly injected steroids was and the more severe the stage and class of rheumatoid arthritis were, the lower the level of adrenaline was and the more reduced the activity of phenylethanolamine-N-methyltransferase was. (2) The level of urinary noradrenaline in patients with rheumatoid arthritis was lower than that of healthy subjects, but there was no relationship between the level of noradrenaline and the amount of intraarticularly injected steroids.
Negative_regulation (reduced) of phenylethanolamine-N-methyltransferase associated with noradrenaline and rheumatoid arthritis
3) Confidence 0.58 Published 1977 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 918958 Disease Relevance 0.59 Pain Relevance 0.61
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Negative_regulation (lowered) of PNMT in nucleus associated with clonidine
4) Confidence 0.57 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.32 Pain Relevance 0.65
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Negative_regulation (inhibitor) of PNMT
5) Confidence 0.57 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07
CGS19281A, a phenylethanolamine N-methyltransferase (PNMT) inhibitor, is reported not to inhibit alpha-2-adrenoceptor activity, in vitro.
Negative_regulation (inhibitor) of PNMT
6) Confidence 0.57 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0
The inhibitor of phenylethanolamine-N-methyl transferase (PNMT), SK&F 64139 (7, 8-dichloro-1, 2, 3, 4-tetrahydroisoquinoline), when given i.v. (5 mg/kg), did not prevent the decrease of blood pressure induced in conscious spontaneously hypertensive rats (SHR) by alpha-methyldopa (50 mg/kg i.v.).
Negative_regulation (inhibitor) of PNMT in blood associated with hypertension
7) Confidence 0.57 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6132343 Disease Relevance 0.23 Pain Relevance 0.27
In pithed rats the pressor responses to both methoxamine and clonidine were antagonized by SK & F 64139 suggesting blockade of vascular alpha 1-and alpha 2-adrenoceptors by the PNMT inhibitor.
Negative_regulation (inhibitor) of PNMT associated with clonidine
8) Confidence 0.57 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6132343 Disease Relevance 0.32 Pain Relevance 0.59
By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F 64139 and DCMB, drugs which are both potent inhibitors of the A-forming enzyme phenylethanolamine-N-methyltransferase (PNMT).
Negative_regulation (inhibitors) of PNMT in neurons associated with locus ceruleus
9) Confidence 0.57 Published 1981 Journal Brain Res. Section Abstract Doc Link 7284809 Disease Relevance 0 Pain Relevance 0.46
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Negative_regulation (lowered) of phenylethanolamine N-methyltransferase in nucleus associated with clonidine
10) Confidence 0.54 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.32 Pain Relevance 0.65
A small series of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines (4-fluoro-THBAs; 12-15) were synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) and as inhibitors of the binding of clonidine at the alpha(2)-adrenoceptor. 4-Fluoro-THBAs 13-15 displayed selectivity ratios (alpha(2) K(i)/PNMT K(i)) greater than 75 and 4-fluoro-8-nitro-THBA (13) was found to be one of the most selective inhibitors of PNMT known, with a selectivity ratio of greater than 900.
Negative_regulation (inhibitors) of phenylethanolamine N-methyltransferase associated with clonidine
11) Confidence 0.48 Published 2001 Journal J. Med. Chem. Section Abstract Doc Link 11495596 Disease Relevance 0 Pain Relevance 0.10
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Negative_regulation (inhibitors) of phenylethanolamine N-methyltransferase
12) Confidence 0.48 Published 2001 Journal J. Med. Chem. Section Title Doc Link 11495596 Disease Relevance 0 Pain Relevance 0.09
When rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p. before decapitation, the l-propranolol-induced decrease was abolished completely.
Negative_regulation (inhibitor) of phenylethanolamine N-methyltransferase associated with decapitation
13) Confidence 0.46 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982014 Disease Relevance 0.10 Pain Relevance 0.25
A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT) and as inhibitors of the binding of clonidine at the alpha(2)-adrenoceptor.
Negative_regulation (inhibitors) of phenylethanolamine N-methyltransferase associated with clonidine
14) Confidence 0.45 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.10
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Negative_regulation (inhibitors) of phenylethanolamine N-methyltransferase
15) Confidence 0.45 Published 1999 Journal J. Med. Chem. Section Title Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.09
Spontaneous and evoked release of epinephrine was markedly reduced, when rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p., before decapitation.
Negative_regulation (inhibitor) of phenylethanolamine N-methyltransferase associated with decapitation
16) Confidence 0.43 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2864433 Disease Relevance 0.10 Pain Relevance 0.13
The influence of SK & F 64139, a phenylethanolamine-N-methyltransferase inhibitor, on centrally mediated cardiovascular effects of alpha-methyldopa and clonidine.
Negative_regulation (inhibitor) of phenylethanolamine-N-methyltransferase associated with clonidine
17) Confidence 0.43 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 6132343 Disease Relevance 0.31 Pain Relevance 0.51
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Negative_regulation (declined) of PNMT
18) Confidence 0.42 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Negative_regulation (inhibitor) of PNMT
19) Confidence 0.42 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07
All the above mentioned effects of SK&F 64139 were mimicked by SK&F 72223, a structurally analogous compound which is reported to lack PNMT inhibitory activity.
Negative_regulation (lack) of PNMT
20) Confidence 0.42 Published 1981 Journal Brain Res. Section Abstract Doc Link 7284809 Disease Relevance 0 Pain Relevance 0.56

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