INT39226

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
hypothalamus 2
tail 2
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
tail-flick 1 100.00 Very High Very High Very High
dexamethasone 1 91.76 High High
medulla 2 76.40 Quite High
antinociception 1 75.00 Quite High
Endogenous opioid 1 49.12 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 3 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are no changes in [3H] GEMSA binding in the supraoptic nucleus or magnocellular portion of the paraventricular nucleus of the hypothalamus under any of these conditions, suggesting that the alterations observed in the neurohypophysis result from an increased rate of loss of enkephalin convertase.
Positive_regulation (increased) of Negative_regulation (loss) of enkephalin convertase in hypothalamus associated with enkephalin
1) Confidence 0.45 Published 1985 Journal Endocrinology Section Abstract Doc Link 3928337 Disease Relevance 0.17 Pain Relevance 0.45
The present investigations showed that the inhibitory effect of [Met(5)]enkephalin-Arg-Gly-Leu administered intra-third-ventricularly on the tail-flick response was increased more than 1000-fold by the intra-third-ventricular pretreatment of rats with three peptidase inhibitors.
Positive_regulation (increased) of Negative_regulation (effect) of enkephalin-Arg-Gly-Leu in tail associated with tail-flick and enkephalin
2) Confidence 0.04 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12393059 Disease Relevance 0 Pain Relevance 0.48

General Comments

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