INT39229

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.20
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
macrophages 2
brain 2
heart 2
bone marrow 1
platelet 1
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
cINOD 25 94.16 High High
Inflammatory mediators 1 93.84 High High
Central nervous system 40 90.44 High High
Inflammation 24 86.00 High High
Potency 2 85.76 High High
Paracetamol 2 83.40 Quite High
Analgesic 2 82.92 Quite High
depression 8 80.96 Quite High
antagonist 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Aging 156 99.98 Very High Very High Very High
Cancer 78 98.76 Very High Very High Very High
Pancreatic Cancer 84 98.68 Very High Very High Very High
INFLAMMATION 31 93.44 High High
Brain Disease 4 91.84 High High
Arthritis 2 85.60 High High
Coronary Artery Disease 4 84.76 Quite High
Depression 8 80.96 Quite High
Lifespan 4 72.16 Quite High
Colon Cancer 5 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.
Spec (whether) Regulation (affects) of 5-LOX in heart associated with aging
1) Confidence 0.57 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.47 Pain Relevance 0.14
The results show that the metabolism of arachidonic acid in macrophages via the cyclooxygenase or the lipoxygenase pathway is dependent on the stimulus applied.
Regulation (metabolism) of lipoxygenase in macrophages
2) Confidence 0.36 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 3928518 Disease Relevance 0.15 Pain Relevance 0.13
The results show that the metabolism of arachidonic acid in macrophages via the cyclooxygenase or the lipoxygenase pathway is dependent on the stimulus applied.
Regulation (metabolism) of lipoxygenase in macrophages
3) Confidence 0.36 Published 1984 Journal Agents Actions Section Abstract Doc Link 6433678 Disease Relevance 0.23 Pain Relevance 0.32
In conclusion, we found that in addition to altering 5-LOX mRNA content in heart and brain tissues, aging increased 5-LOX DNA methylation, and also that this effect was DNA-site- and tissue-specific.
Regulation (altering) of 5-LOX in heart associated with aging
4) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.43 Pain Relevance 0.23
Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.
Spec (whether) Regulation (affects) of 5-LOX in brain associated with aging
5) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.47 Pain Relevance 0.14
In conclusion, we found that in addition to altering 5-LOX mRNA content in heart and brain tissues, aging increased 5-LOX DNA methylation, and also that this effect was DNA-site- and tissue-specific.
Regulation (altering) of 5-LOX in brain associated with aging
6) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.43 Pain Relevance 0.23
In the present study the effects of drugs affecting 5-lipoxygenase activity, the actions of platelet activating factor and intracellular calcium on the development of gastric and intestinal ulceration induced by NSAIDs were investigated in highly sensitive models of ulcerogenicity induced by treatment with either the cholinomimetic, acetyl-beta-methyl choline chloride, in mice (gastric mucosal lesions) or adjuvant-induced polyarthritis in rats (gastric and intestinal mucosal lesions) as well as in normal mice (intestinal mucosal lesions).
Regulation (affecting) of lipoxygenase in platelet associated with cinod and arthritis
7) Confidence 0.07 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10344635 Disease Relevance 0.34 Pain Relevance 0.36
Feasibility of targeting cyclooxygenase and lipoxygenase for treatment and prevention of pancreatic cancer
Regulation (targeting) of lipoxygenase associated with pancreatic cancer
8) Confidence 0.06 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.67 Pain Relevance 0.06
Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Regulation (Effects) of 5-lipoxygenase in bone marrow associated with cox2
9) Confidence 0.04 Published 2006 Journal Arch. Pharm. Res. Section Title Doc Link 17121182 Disease Relevance 0 Pain Relevance 0.11

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