INT39242

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 5.15
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tooth pulp 2
tail 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1829 100.00 Very High Very High Very High
Pain 48 99.80 Very High Very High Very High
analgesia 9 99.36 Very High Very High Very High
Analgesic 3 96.56 Very High Very High Very High
imagery 10 94.24 High High
Pain threshold 3 72.04 Quite High
b2 receptor 21 56.40 Quite High
bradykinin 21 50.00 Quite Low
Inflammation 4 16.56 Low Low
Angina 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 9 99.88 Very High Very High Very High
Pain 45 99.80 Very High Very High Very High
Trepenoma Infection 111 98.98 Very High Very High Very High
Stress 57 98.56 Very High Very High Very High
Disease 31 97.00 Very High Very High Very High
Increased Venous Pressure Under Development 68 92.88 High High
Hypertension 62 88.88 High High
Infection 11 86.84 High High
Targeted Disruption 20 85.28 High High
Recurrence 2 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are no cases where the TP-JOR is suppressed and pain is still experienced from tooth pulp shock; the suppression of the TP-JOR may therefore be an accurate index of analgesia.
Negative_regulation (suppression) of TP-JOR in tooth pulp associated with pain, shock and analgesia
1) Confidence 0.58 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.28 Pain Relevance 1.55
However, in humans treatments that produce analgesia have not been shown to produce suppression of the TP-JOR.
Negative_regulation (suppression) of TP-JOR associated with analgesia
2) Confidence 0.43 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.18 Pain Relevance 1.50
There are no cases where the TP-JOR is suppressed and pain is still experienced from tooth pulp shock; the suppression of the TP-JOR may therefore be an accurate index of analgesia.
Negative_regulation (suppressed) of TP-JOR in tooth pulp associated with pain, shock and analgesia
3) Confidence 0.43 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.32 Pain Relevance 1.56
Greater progress towards deciphering the pathogenesis of the paradoxical nature of venereal syphilis has been hampered due to the inability to readily propagate Tp in vitro, as well as the lack of a suitable inbred animal model to study the disease.
Negative_regulation (propagate) of Tp in associated with disease and trepenoma infection
4) Confidence 0.35 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 1.01 Pain Relevance 0
Thereafter, having optimised the conditions for effective RNAi disruption of TP?
Negative_regulation (disruption) of TP
5) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
It was notable that the level of siRNA-mediated impairment of TP?
Negative_regulation (impairment) of TP
6) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0
To confirm the efficacy of the siRNAs to disrupt TP?
Negative_regulation (disrupt) of TP
7) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
receptor isoforms in terms of their regulation of Rho signaling that are likely to be physiologically relevant in human tissues such as SM and suggest that selective targeting and impairment of TP?
Negative_regulation (impairment) of TP
8) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.18 Pain Relevance 0
, in the HEK 293 over-expression system at least, are due to direct effects on TP?
Negative_regulation (effects) of TP
9) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
does not involve its internalization while desensitization of TP?
Negative_regulation (desensitization) of TP
10) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
We initially investigated desensitization of TP?
Spec (investigated) Negative_regulation (desensitization) of TP
11) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
and are consistent with findings herein indicating that desensitization of TP?
Negative_regulation (desensitization) of TP
12) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
Moreover, pre-incubation with KT 5823 reduced the level of agonist-induced TP?
Negative_regulation (reduced) of TP associated with agonist
13) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.20
Hence, based on data presented herein, we propose a model for the mechanism of homologous desensitization of TP?
Negative_regulation (desensitization) of TP
14) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
Hence, in summary, it is indeed evident that there are fundamental differences in the mechanisms of homologous desensitization of TP?
Negative_regulation (desensitization) of TP
15) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
Hence the loss of the secondary U46619-response was not due to mechanical stress during agonist-washout per se but rather resulted from agonist-induced desensitization of TP?
Negative_regulation (desensitization) of TP associated with stress and agonist
16) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.10 Pain Relevance 0.14
Similarly, the sGC and NOS inhibitors LY 83583 (30%) and l-NAME (40%), respectively, yielded significant impairments in agonist-induced desensitization of TP?.
Negative_regulation (desensitization) of TP associated with agonist
17) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
These data suggest that Thr337, a site previously established to act as a PKC site [32], plays a significant role in the homologous desensitization of TP?  
Negative_regulation (desensitization) of TP
18) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
On the other hand, mutation of Ser331 or Thr337 alone or in combination with each other or with Ser145 led to partial or near complete impairment of agonist-induced desensitization of TP?.
Negative_regulation (desensitization) of TP associated with agonist
19) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
Hence, taken collectively, our data generated from the systematic Ala-scanning mutagenesis studies indicate a specific role for Ser145 located in IC2, Ser331 and Thr337 located within the C-tail domain in the agonist-induced desensitization of TP?
Negative_regulation (desensitization) of TP in tail associated with agonist
20) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox