INT39243

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Context Info
Confidence 0.61
First Reported 1985
Last Reported 2010
Negated 7
Speculated 3
Reported most in Body
Documents 20
Total Number 26
Disease Relevance 5.66
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
blood 1
tooth pulp 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 100.00 Very High Very High Very High
agonist 912 99.00 Very High Very High Very High
Pain threshold 1 79.04 Quite High
analgesia 3 78.64 Quite High
b2 receptor 9 76.24 Quite High
bradykinin 9 69.84 Quite High
Analgesic 1 65.60 Quite High
Angina 21 59.40 Quite High
COX2 9 27.84 Quite Low
Inflammation 16 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 15 100.00 Very High Very High Very High
Trepenoma Infection 444 99.14 Very High Very High Very High
Sexually Transmitted Diseases 28 95.44 Very High Very High Very High
Alopecia 8 95.40 Very High Very High Very High
Targeted Disruption 48 95.00 High High
Exanthema 20 87.72 High High
Injury 9 84.84 Quite High
Shock 3 84.64 Quite High
Disease 108 82.84 Quite High
Thrombosis 54 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TP-JOR and the tooth pulp-evoked pain are affected in parallel by sensory habituation and both appear to relay in the rostral trigeminal complex.
Regulation (affected) of TP-JOR in tooth pulp associated with pain
1) Confidence 0.61 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.39 Pain Relevance 1.58
A 10µl sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Regulation (targets) of Tp
2) Confidence 0.59 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
PCR inhibition was not observed in any of the DNA samples that tested negative for the Tp polA target.
Regulation (target) of Tp
3) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.30 Pain Relevance 0
Samples were tested using a real-time PCR targeting the Tp polA gene (Gene Bank Accession No.
Regulation (targeting) of Tp
4) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.22 Pain Relevance 0
Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods.
Regulation (target) of Tp DNA in blood associated with trepenoma infection
5) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2872645 Disease Relevance 1.10 Pain Relevance 0
Additionally, RNAi directed to Lamin A/C, acting as a control, had no effect on either TP?
Neg (no) Regulation (effect) of TP
6) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.23 Pain Relevance 0
Moreover, in view of the critical involvement of inhibitory agents including prostacyclin and NO, that largely signal through cAMP and cGMP second messengers, in regulating RhoA-dependent mechanisms [1,6,35,36] coupled to their role in differentially regulating TP?
Regulation (regulating) of TP
7) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.44 Pain Relevance 0.06
On the other hand, neither vasodilatory agent directly target TP?.
Neg (neither) Regulation (target) of TP
8) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
did not affect TP?
Neg (not) Regulation (affect) of TP
9) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.26 Pain Relevance 0
On the other hand, neither vasodilatory agent directly target TP?.
Neg (neither) Regulation (target) of TP
10) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0
did not affect TP?
Neg (not) Regulation (affect) of TP
11) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.25 Pain Relevance 0
is the major regulatory TP isoform involved in vascular hemostasis being a direct target for inhibition of both its Gq/PLC?
Regulation (regulatory) of TP isoform
12) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
The effect of prostacyclin/cAMP and NO/cGMP on TP?
Regulation (effect) of TP
13) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
To begin with, the siRNA agents were validated by examining their ability to affect TP?
Spec (examining) Regulation (affect) of TP
14) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.26 Pain Relevance 0
independently or indeed differentially modulate RhoA activation and downstream signaling, there is substantial evidence that the TP?
Regulation (modulate) of TP
15) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.18 Pain Relevance 0.04
independently contribute to U46619-induced RhoA activation and signaling in 1° h.AoSMCs and to ascertain whether the inhibitory effects of NO and/or Cicaprost may directly target TP?
Spec (may) Regulation (target) of TP
16) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.05
isoforms of the human thromboxane A2 receptor: Independent modulation of TP?
Regulation (modulation) of TP
17) Confidence 0.11 Published 2008 Journal Cellular Signalling Section Title Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
[15,25,26], they oppositely regulate adenylyl cyclase [27] and TP?
Regulation (regulate) of TP
18) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.15 Pain Relevance 0.03
The regulation of TP?
Regulation (regulation) of TP
19) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
undergoes agonist-induced PKG phosphorylation, we investigated the effect of KT 5823 on TP?
Spec (investigated) Regulation (effect) of TP associated with agonist
20) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.22

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