INT39244

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2010
Negated 2
Speculated 9
Reported most in Body
Documents 137
Total Number 154
Disease Relevance 14.55
Pain Relevance 11.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 5
skin 4
platelets 3
blood 2
arterioles 1
TMPO (Homo sapiens)
TMPO - S331A (3) TMPO - S329A (3)
Pain Link Frequency Relevance Heat
Central nervous system 14 99.92 Very High Very High Very High
Pain 36 99.80 Very High Very High Very High
agonist 6342 99.64 Very High Very High Very High
analgesia 6 99.52 Very High Very High Very High
Neuropeptide 9 97.12 Very High Very High Very High
antagonist 76 96.80 Very High Very High Very High
Analgesic 2 96.56 Very High Very High Very High
cytokine 3 95.84 Very High Very High Very High
substance P 19 89.28 High High
Inflammation 50 86.12 High High
Disease Link Frequency Relevance Heat
Rhinitis 250 99.92 Very High Very High Very High
Targeted Disruption 296 99.88 Very High Very High Very High
Trepenoma Infection 999 99.84 Very High Very High Very High
Pain 34 99.80 Very High Very High Very High
Hypersensitivity 32 98.88 Very High Very High Very High
Shock 6 98.12 Very High Very High Very High
Sprains And Strains 126 95.84 Very High Very High Very High
Leukemia 74 93.52 High High
Congenital Anomalies 11 92.04 High High
Acanthosis 9 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in humans treatments that produce analgesia have not been shown to produce suppression of the TP-JOR.
Gene_expression (produce) of TP-JOR associated with analgesia
1) Confidence 0.77 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.18 Pain Relevance 1.51
Detection of Tp DNA (polA) in Whole Blood (WB) of Secondary Syphilis Patients by Real-Time Quantitative PCR (qPCR)
Gene_expression (Detection) of Tp DNA in Blood associated with trepenoma infection
2) Confidence 0.74 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.67 Pain Relevance 0
There are no cases where the TP-JOR is suppressed and pain is still experienced from tooth pulp shock; the suppression of the TP-JOR may therefore be an accurate index of analgesia.
Gene_expression (suppressed) of TP-JOR in tooth pulp associated with pain, shock and analgesia
3) Confidence 0.66 Published 1985 Journal Brain Res. Section Abstract Doc Link 3931861 Disease Relevance 1.32 Pain Relevance 1.56
Tp DNA was also present in 8/12 (66%) skin biopsies available for testing.
Gene_expression (present) of Tp DNA in skin
4) Confidence 0.64 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2872645 Disease Relevance 1.02 Pain Relevance 0
It is important to note that the ability to detect Tp DNA in SS patients' samples greatly improved when WB DNA was extracted within a few hours of procurement of the sample.
Gene_expression (detect) of Tp DNA associated with trepenoma infection
5) Confidence 0.64 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.31 Pain Relevance 0
Five of the 8 patients had Tp DNA present in both the blood and the skin, one patient with spirochetemia had a negative PCR in the skin; and two patients with detectable DNA in punch biopsy material had negative PCR results in WB.


Gene_expression (present) of Tp DNA in skin
6) Confidence 0.64 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.48 Pain Relevance 0
While frozen blood samples, stored over several days, may not be conducive to diagnostic PCR testing, our spiking experiments do indicate that blood samples can be stored up to 26 hours at 4°C without significantly affecting the capacity to detect Tp DNA.
Gene_expression (detect) of Tp DNA in blood
7) Confidence 0.64 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.42 Pain Relevance 0
PCR inhibition was not observed in any of the DNA samples that tested negative for the Tp polA target.
Gene_expression (target) of Tp
8) Confidence 0.64 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.30 Pain Relevance 0
Tp DNA was also present in the skin of 66% (12/26) of biopsies tested by PCR.
Gene_expression (present) of Tp DNA in skin
9) Confidence 0.50 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2872645 Disease Relevance 1.28 Pain Relevance 0.03
Tp DNA was also detected by qualitative real-time PCR in 8/12 (66%) skin biopsies studied (Table 4).
Gene_expression (detected) of Tp DNA in skin
10) Confidence 0.50 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.36 Pain Relevance 0
Several other investigators have previously used molecular methods to detect Tp DNA in WB and tissues from untreated early syphilis patients [58]–[65].
Gene_expression (detect) of Tp DNA associated with trepenoma infection
11) Confidence 0.50 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 1.20 Pain Relevance 0.04
Immunocytochemical observations have shown that the secreted thymic hormones, thymosin alpha 1 and thymopoietin (and its short form, thymopentin or TP5), are produced by the same RE cells.
Gene_expression (produced) of thymopoietin
12) Confidence 0.45 Published 1999 Journal In Vivo Section Abstract Doc Link 10459506 Disease Relevance 0 Pain Relevance 0.20
In the review the influence of the following immunopeptides on CNS is presented: tuftsin, thymulin, thymopoietin and thymopentin, thymosins, and thymic humoral factor.
Gene_expression (presented) of thymopoietin in CNS associated with central nervous system
13) Confidence 0.43 Published 2005 Journal Amino Acids Section Abstract Doc Link 16059661 Disease Relevance 0 Pain Relevance 0.36
The secreted thy nic hormones, thymulin, thymosin-alpha 1 and thymopoietin (its short form, thymopentin or TP5) were detected immunocytochemically to be produced by RE cells.
Gene_expression (produced) of thymopoietin
14) Confidence 0.37 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.15
-mediated RhoA signaling by either Cicaprost or SIN-1, such as might be expected to occur at a later point in the signaling cascade [36], could in theory be due to the fact that the level of TP receptor expression in the HEK 293 stable cell lines produces an overriding forward signal, overwhelming any inhibitory effects of prostacyclin or NO.
Gene_expression (expression) of TP receptor
15) Confidence 0.35 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.10
expression in HEK.TP?
Gene_expression (expression) of TP
16) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.25 Pain Relevance 0
However, as stated, our data generated in the HEK 293 cell lines over-expressing the individual TP?
Gene_expression (-) of TP
17) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
to mediate RhoA signaling in established clonal HEK 293 cell lines that over-express the individual TP isoforms [20,21] and in cultured 1° AoSMCs, a physiologically relevant cell type that expresses both TP?
Gene_expression (express) of TP
18) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.12 Pain Relevance 0
plays a critical role in vascular haemostasis acting as the major TP target for regulation/inhibition by prostacyclin and NO, such as within the anucleate platelet that predominantly expresses TP?.
Gene_expression (expresses) of TP in platelet
19) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
expressed in HEK.TP?
Gene_expression (expressed) of TP
20) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

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