INT39246

Context Info Confidence 0.62 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 2.50 Pain Relevance 0.48

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC) nucleolus (PGC) nucleus (PGC)

Anatomy Link Frequency gastric juice 2 lumen 1 PGC (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 94 93.52 peptic ulcer disease 4 93.40 tissue acidosis 2 79.44 Bile 2 71.00 antagonist 10 55.60 Calcitonin gene-related peptide 8 33.68 agonist 4 14.04 headache 3 5.68 anesthesia 4 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 3 99.76 Increased Venous Pressure Under Development 52 99.40 Hypersensitivity 9 96.60 Duodenal Ulcer 2 94.16 Disease 10 93.40 Injury 44 93.12 Ulcers 6 93.08 Acidosis 2 78.88 Acid Reflux 10 73.16 Hypoglycemia 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the expectation that fluid extracts would be increasingly profitable, Burroughs arranged for the Wyeths to supply a range of these, including jasmine, dock, and sarsaparilla.64 A significant next step was the advertisement of a range of items having trademarks registered under his own name: Silas Burroughs's Bromide of Potassium and Calisaya Bark Elixirs, Dextra Quinine, Pepsin, and Hazeline.65 His introduction of Silas Burroughs's Beef and Iron Wine (improved) “A HIGHLY CONCENTRATED STRENGTH GIVING FOOD TONIC” in the spring of 1880, offended the Wyeths who regarded it as being in competition with their own Beef and Iron Juice.

Gene_expression (introduction) of Pepsin

1) Confidence 0.62 Published 2005 Journal Medical History Section Body Doc Link PMC1172290 Disease Relevance 0 Pain Relevance 0

RESULTS: Pepsin 1 was present in 23 out of 24 basal gastric juice samples at a mean concentration of approximately 12 microg/ml.

Gene_expression (present) of Pepsin in gastric juice

2) Confidence 0.55 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0

Pepsin in gastric juice will rapidly dissolve this mucus cover and can be active up to luminal pH values of 5.

Gene_expression (dissolve) of Pepsin in gastric juice

3) Confidence 0.37 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3932055 Disease Relevance 0.19 Pain Relevance 0.13

Other tests, such as resistance to pepsin digestion under appropriate conditions, may further improve assessment accuracy (25,40).

Gene_expression (digestion) of pepsin

4) Confidence 0.04 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1933222 Disease Relevance 0.10 Pain Relevance 0

One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.

Gene_expression (produced) of pepsin precursor in lumen associated with duodenal ulcer

5) Confidence 0.01 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.70 Pain Relevance 0.16

In another study, a 90-min esophageal perfusion with a pH 1.4 solution + 0.5% pepsin produced only edema or hyperemia in 8/9 rats [24].

Gene_expression (produced) of pepsin associated with pressure and volume under development and increased venous pressure under development

6) Confidence 0.01 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.96 Pain Relevance 0.07

Data are expressed as mean ± SEM (n = 6). * p < 0.05 versus pH 7.0 Krebs group, † p < 0.05 versus pH 1.0 group, ‡ p < 0.05 versus pH 1.0 + pepsin group

Gene_expression (expressed) of pepsin

7) Confidence 0.01 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.56 Pain Relevance 0.12

General Comments

This test has worked.