INT39246

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.50
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC)
nucleolus (PGC) nucleus (PGC)
Anatomy Link Frequency
gastric juice 2
lumen 1
PGC (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 94 93.52 High High
peptic ulcer disease 4 93.40 High High
tissue acidosis 2 79.44 Quite High
Bile 2 71.00 Quite High
antagonist 10 55.60 Quite High
Calcitonin gene-related peptide 8 33.68 Quite Low
agonist 4 14.04 Low Low
headache 3 5.68 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 3 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 52 99.40 Very High Very High Very High
Hypersensitivity 9 96.60 Very High Very High Very High
Duodenal Ulcer 2 94.16 High High
Disease 10 93.40 High High
Injury 44 93.12 High High
Ulcers 6 93.08 High High
Acidosis 2 78.88 Quite High
Acid Reflux 10 73.16 Quite High
Hypoglycemia 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the expectation that fluid extracts would be increasingly profitable, Burroughs arranged for the Wyeths to supply a range of these, including jasmine, dock, and sarsaparilla.64 A significant next step was the advertisement of a range of items having trademarks registered under his own name: Silas Burroughs's Bromide of Potassium and Calisaya Bark Elixirs, Dextra Quinine, Pepsin, and Hazeline.65 His introduction of Silas Burroughs's Beef and Iron Wine (improved) “A HIGHLY CONCENTRATED STRENGTH GIVING FOOD TONIC” in the spring of 1880, offended the Wyeths who regarded it as being in competition with their own Beef and Iron Juice.
Gene_expression (introduction) of Pepsin
1) Confidence 0.62 Published 2005 Journal Medical History Section Body Doc Link PMC1172290 Disease Relevance 0 Pain Relevance 0
RESULTS: Pepsin 1 was present in 23 out of 24 basal gastric juice samples at a mean concentration of approximately 12 microg/ml.
Gene_expression (present) of Pepsin in gastric juice
2) Confidence 0.55 Published 2007 Journal Scand. J. Gastroenterol. Section Body Doc Link 17454875 Disease Relevance 0 Pain Relevance 0
Pepsin in gastric juice will rapidly dissolve this mucus cover and can be active up to luminal pH values of 5.
Gene_expression (dissolve) of Pepsin in gastric juice
3) Confidence 0.37 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3932055 Disease Relevance 0.19 Pain Relevance 0.13
Other tests, such as resistance to pepsin digestion under appropriate conditions, may further improve assessment accuracy (25,40).


Gene_expression (digestion) of pepsin
4) Confidence 0.04 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1933222 Disease Relevance 0.10 Pain Relevance 0
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Gene_expression (produced) of pepsin precursor in lumen associated with duodenal ulcer
5) Confidence 0.01 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.70 Pain Relevance 0.16
In another study, a 90-min esophageal perfusion with a pH 1.4 solution + 0.5% pepsin produced only edema or hyperemia in 8/9 rats [24].
Gene_expression (produced) of pepsin associated with pressure and volume under development and increased venous pressure under development
6) Confidence 0.01 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.96 Pain Relevance 0.07
Data are expressed as mean ± SEM (n = 6). * p < 0.05 versus pH 7.0 Krebs group, † p < 0.05 versus pH 1.0 group, ‡ p < 0.05 versus pH 1.0 + pepsin group


Gene_expression (expressed) of pepsin
7) Confidence 0.01 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.56 Pain Relevance 0.12

General Comments

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