INT39249

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.72
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (NPL) carbohydrate metabolic process (NPL) cytoplasm (NPL)
Anatomy Link Frequency
plasma 1
NPL (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 98 100.00 Very High Very High Very High
narcan 47 100.00 Very High Very High Very High
qutenza 94 99.72 Very High Very High Very High
Inflammation 4 89.48 High High
antagonist 6 89.12 High High
Opioid 18 88.64 High High
amygdala 55 82.08 Quite High
opiate 1 69.40 Quite High
medulla 2 63.76 Quite High
Endogenous opioid 1 57.96 Quite High
Disease Link Frequency Relevance Heat
Rhinitis 4 99.62 Very High Very High Very High
Frailty 10 99.24 Very High Very High Very High
Cough 48 98.42 Very High Very High Very High
Asthma 14 94.88 High High
Hypersensitivity 16 94.44 High High
INFLAMMATION 2 89.48 High High
Congenital Anomalies 2 87.40 High High
Muscle Weakness 1 86.24 High High
Hypopituitarism 1 85.08 High High
Mucositis 2 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma glucagon response to exercise at 70% VO2max was not altered by NAL administration but was significantly elevated in the 90%-NAL vs. the 90%-SAL trial.
Positive_regulation (elevated) of NAL in plasma
1) Confidence 0.41 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7928870 Disease Relevance 0 Pain Relevance 0.27
Alprazolam (APZ) attenuates the ACTH release in response to Nal in normal individuals, probably by inhibiting CRH release.
Spec (probably) Positive_regulation (attenuates) of Nal associated with narcan
2) Confidence 0.31 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663654 Disease Relevance 1.10 Pain Relevance 0.37
After TP, however, despite unchanged basal LH levels (mean +/- S.E.M.: 27.0 +/- 3.4 vs 21.2 +/- 3.21 microU/ml), LH significantly increased in response to NAL.
Positive_regulation (increased) of NAL associated with narcan
3) Confidence 0.24 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.15 Pain Relevance 0.51
The main finding of this study is that patients with SHR do have enhanced cough sensitivity to inhaled capsaicin, which correlates to a small but significant increase in NGF in NAL after capsaicin provocation.
Positive_regulation (increase) of NAL associated with nerve growth factor, qutenza and cough
4) Confidence 0.06 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.37 Pain Relevance 0.89
In patients with allergic rhinitis, levels of NGF in NAL were increased after allergen provocation compared with control subjects (Sanico et al. 2000).
Positive_regulation (increased) of NAL associated with rhinitis and nerve growth factor
5) Confidence 0.06 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.83 Pain Relevance 0.74
These observations rule out the possibility that the effects of NAL on ERK activity and extinction were the result of an acute effect on freezing.
Positive_regulation (effects) of NAL associated with narcan
6) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.27 Pain Relevance 0.41

General Comments

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