INT3925

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1976
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 29
Total Number 30
Disease Relevance 20.19
Pain Relevance 9.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
Reiter 2
joint 1
bowel 1
B12 1
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 82 99.92 Very High Very High Very High
backache 4 99.28 Very High Very High Very High
Inflammation 16 99.16 Very High Very High Very High
Pain 3 98.40 Very High Very High Very High
Arthritis 84 98.00 Very High Very High Very High
spondylitis 21 97.24 Very High Very High Very High
psoriasis 34 95.00 High High
cINOD 2 90.60 High High
Crohn's disease 1 85.44 High High
Chronic low back pain 1 77.96 Quite High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 98 100.00 Very High Very High Very High
Disease 31 100.00 Very High Very High Very High
Genetic Predisposition To Disease 3 100.00 Very High Very High Very High
Low Back Pain 89 99.92 Very High Very High Very High
Sacroiliitis 12 99.72 Very High Very High Very High
Spondylarthropathies 5 99.34 Very High Very High Very High
INFLAMMATION 11 99.16 Very High Very High Very High
Syndrome 65 98.68 Very High Very High Very High
Inflammatory Bowel Disease 6 98.52 Very High Very High Very High
Diffuse Idiopathic Skeletal Hyperostosis 5 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude, that existence or absence of the tissue antigen HLA-B27 has no influence on inflammatory activity of skeletal or soft tissue manifestations of the disease.
Negative_regulation (absence) of HLA-B27 associated with inflammation and disease
1) Confidence 0.42 Published 1977 Journal Z Rheumatol Section Abstract Doc Link 919796 Disease Relevance 0.61 Pain Relevance 0.55
Absence of HLA-B 27 does not exclude ankylosing spondylitis, as 7.4% of the classical cases are HLA-B27-negative.
Negative_regulation (Absence) of HLA-B associated with spinal inflammation
2) Confidence 0.42 Published 1977 Journal Z Rheumatol Section Abstract Doc Link 919797 Disease Relevance 0.70 Pain Relevance 0.70
The prevalence of spondylarthropathies is directly correlated with the prevalence of the HLA-B27 antigen in the population.
Negative_regulation (prevalence) of HLA-B27 associated with spondylarthropathies
3) Confidence 0.41 Published 1998 Journal Eur J Radiol Section Abstract Doc Link 9652494 Disease Relevance 1.65 Pain Relevance 0.61
Prevalence of HLA-B27 and subtypes of HLA-B27 associated with ankylosing spondylitis in Galicia, Spain.
Negative_regulation (Prevalence) of HLA-B27 associated with spinal inflammation
4) Confidence 0.39 Published 2004 Journal Clin. Exp. Rheumatol. Section Title Doc Link 15301245 Disease Relevance 0.10 Pain Relevance 0.14
The phenotype frequency of HLA-B27 in this Navajo population is 36% and, of the Reiter's syndrome and ankylosing spondylitis patients tested, 85% were found to be HLA-B27 positive.
Negative_regulation (positive) of HLA-B27 in Reiter associated with spinal inflammation and syndrome
5) Confidence 0.39 Published 1980 Journal Arthritis Rheum. Section Abstract Doc Link 7447964 Disease Relevance 1.07 Pain Relevance 0.50
OBJECTIVE: To assess the prevalence of HLA-B27 and its subtypes in both the normal population and in patients with Ankylosing Spondylitis (AS) in Galicia, Northwest Spain.
Negative_regulation (prevalence) of HLA-B27 associated with low back pain and spondylitis
6) Confidence 0.39 Published 2004 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 15301245 Disease Relevance 0.17 Pain Relevance 0.12
In addition, we suggest here that the same selective pressure that has contributed to reduce the HLA-B27 frequency in some regions has favoured the fixing of newly generated B27 subtypes included in more advantageous HLA haplotypes.
Negative_regulation (reduce) of HLA-B27
7) Confidence 0.39 Published 2008 Journal Autoimmun Rev Section Abstract Doc Link 18486928 Disease Relevance 0.74 Pain Relevance 0.11
This paper aims to review the frequencies of HLA-B27 gene and its subtypes in different population groups, possible mechanisms leading to the development of joint inflammation and the risk it confers for development of spondyloarthropathies.
Spec (possible) Negative_regulation (review) of HLA-B27 gene in joint associated with inflammation and arthritis
8) Confidence 0.39 Published 2000 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 10976392 Disease Relevance 0.54 Pain Relevance 0.14
Most but not all of these disorders show an increased prevalence among individuals who have inherited the HLA-B27 gene.
Negative_regulation (inherited) of HLA-B27 gene
9) Confidence 0.39 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10502021 Disease Relevance 1.22 Pain Relevance 0.41
CONCLUSIONS: AS is less common in the Icelandic population than reported in various Caucasian populations with a similar prevalence of HLA-B27.


Negative_regulation (prevalence) of HLA-B27
10) Confidence 0.39 Published 2010 Journal Clin. Exp. Rheumatol. Section Body Doc Link 20406616 Disease Relevance 0 Pain Relevance 0
Prevalence of HLA-B27 in patients with back pain attending a pain clinic.
Negative_regulation (Prevalence) of HLA-B27 associated with pain and backache
11) Confidence 0.39 Published 1991 Journal Pain Section Title Doc Link 1828876 Disease Relevance 0.39 Pain Relevance 0.48
When analysing HLA-B27 with antibodies showing nonspecific reactivity, a cut-off staining level yielding high specificity should be chosen, as the primary diagnostic value of HLA-B27 is as a 'rule-out' test for ankylosing spondylitis.
Negative_regulation (value) of HLA-B27 associated with spinal inflammation
12) Confidence 0.36 Published 2007 Journal International journal of laboratory hematology Section Abstract Doc Link 17988301 Disease Relevance 0.10 Pain Relevance 0.10
In contrast to these traditional spondarthritides three new types are marked by the lack of HLA-B 27. 1) "Spondarthritis hyperostotica pustulo-psoriatica" (F.
Negative_regulation (lack) of HLA-B 27
13) Confidence 0.35 Published 1990 Journal Neurosurg Rev Section Abstract Doc Link 2149172 Disease Relevance 1.39 Pain Relevance 0.21
In 89 patients with inflammatory bowel disease, only one out of 11 patients with radiographic sacroiliitis was found to possess the HLA B27 antigen, while three out of four patients with ankylosing spondylitis were B27 positive.
Negative_regulation (possess) of HLA B27 in bowel associated with seronegative spondarthritis, spinal inflammation, sacroiliitis and inflammation
14) Confidence 0.32 Published 1976 Journal J. Rheumatol. Section Abstract Doc Link 950636 Disease Relevance 0.62 Pain Relevance 0.31
Results suggest any decrease in O2- generation seen in patients with AS is likely to be related to therapy and not to the disease or to possession of HLA B27.
Negative_regulation (possession) of HLA B27 associated with seronegative spondarthritis and disease
15) Confidence 0.32 Published 1986 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 3015467 Disease Relevance 0.53 Pain Relevance 0.24
Two of these cases exhibited HLA B27.
Negative_regulation (exhibited) of HLA B27 associated with seronegative spondarthritis
16) Confidence 0.32 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2515022 Disease Relevance 1.11 Pain Relevance 0.36
RESULTS: Expressions of HLA-B27 mRNA in HLA-B27+ AS patients were significantly higher compared to unaffected B27+ family members and B27+ controls. mRNA for HLA-B27 was observed to be present in higher amounts than for other HLA class I alleles.
Negative_regulation (present) of HLA-B27
17) Confidence 0.31 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0.12 Pain Relevance 0
The distribution of HLA-B27 antigen was also analysed in the three groups of PsA.
Negative_regulation (distribution) of HLA-B27 associated with arthritis
18) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794531 Disease Relevance 0.60 Pain Relevance 0.17
HLA B27 in health and disease: a double-edged sword?
Negative_regulation (double-edged) of HLA B27 associated with seronegative spondarthritis and disease
19) Confidence 0.19 Published 2002 Journal Rheumatology (Oxford) Section Title Doc Link 12154202 Disease Relevance 1.41 Pain Relevance 0.41
Of 88 HLA-B27 positive individuals from these villages, all had HLA-B*2705, including the four patients with Reiter's syndrome and the five ankylosing spondylitis, except one Eskimo control who had HLA-B*2702.
Negative_regulation (had) of HLA-B in Reiter associated with spinal inflammation and syndrome
20) Confidence 0.17 Published 1995 Journal Tissue Antigens Section Abstract Doc Link 8838347 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox