INT39256

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Context Info
Confidence 0.74
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.62
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
PGE2 3
platelet 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 6 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
aspirin 21 99.84 Very High Very High Very High
cOX1 2 99.76 Very High Very High Very High
cINOD 49 99.24 Very High Very High Very High
Inflammation 206 98.38 Very High Very High Very High
chemokine 31 93.68 High High
cytokine 58 93.20 High High
Analgesic 6 92.04 High High
COX-2 inhibitor 3 90.32 High High
Disease Link Frequency Relevance Heat
Colon Cancer 10 100.00 Very High Very High Very High
Adhesions 10 99.62 Very High Very High Very High
Occupational Lung Diseases 7 99.12 Very High Very High Very High
INFLAMMATION 249 98.38 Very High Very High Very High
Cancer 136 94.36 High High
Apoptosis 10 93.00 High High
Asthma 51 92.20 High High
Metastasis 5 90.44 High High
Corneal Neovascularization 2 88.88 High High
Ulcers 4 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting data showed a similar distribution of PGHS-1 and -2 in subcellular fractions, and product analysis using isozyme-specific inhibitors suggested that both enzymes generate the same products in NIH 3T3 cells.
Localization (distribution) of PGHS-1
1) Confidence 0.74 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9545330 Disease Relevance 0.06 Pain Relevance 0.09
However, differences were observed in the ability of the hPGHS isoforms to utilize endogenous arachidonic acid released intracellularly following calcium ionophore stimulation or released by human cytosolic phospholipase A2 transiently expressed in the cells.
Localization (released) of PGHS
2) Confidence 0.73 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.15 Pain Relevance 0.38
Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.
Localization (localization) of endoperoxide H synthases-1 associated with cox1
3) Confidence 0.69 Published 1998 Journal J. Biol. Chem. Section Title Doc Link 9545330 Disease Relevance 0.09 Pain Relevance 0.24
Notably, the S(+)-isomer of ibuprofen was 32-, 41-, and 96-fold more potent than the R(-)-isomer for the inhibition of PGHS-1 activity, human platelet aggregation, and serotonin secretion, respectively.
Localization (secretion) of PGHS-1 in platelet associated with serotonin
4) Confidence 0.58 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0 Pain Relevance 0.24
Long-term use of cyclooxygenase (COX) inhibitors (NSAIDs) in humans leads to a 50% reduction in risk for colorectal cancer.
Localization (use) of cyclooxygenase associated with colon cancer and cinod
5) Confidence 0.28 Published 2007 Journal Cell Cycle Section Abstract Doc Link 17374999 Disease Relevance 0.55 Pain Relevance 0.14
The IC50-values obtained for the inhibition of lipopolysaccharide (LPS)-induced release of prostaglandin E2 (PGE2) reflecting cyclooxygenase (COX)-2-mediated PGE2 release were 47 microg/ml and 0.6 microg/ml, for the Salix extract 1520L and rofecoxib-like research compound L745337, respectively.
Localization (release) of cyclooxygenase in PGE2
6) Confidence 0.24 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.40 Pain Relevance 0.25
The IC50-values obtained for the inhibition of lipopolysaccharide (LPS)-induced release of prostaglandin E2 (PGE2) reflecting cyclooxygenase (COX)-2-mediated PGE2 release were 47 microg/ml and 0.6 microg/ml, for the Salix extract 1520L and rofecoxib-like research compound L745337, respectively.
Localization (release) of cyclooxygenase in PGE2
7) Confidence 0.21 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.40 Pain Relevance 0.25
Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?
Localization (cause) of Cyclooxygenase associated with colon cancer and cox2
8) Confidence 0.19 Published 2009 Journal Expert Opin. Ther. Targets Section Title Doc Link 19236238 Disease Relevance 0.86 Pain Relevance 0.34
Sodium salicylate and salicylamide, which, though structurally similar to aspirin, do not inhibit cyclooxygenase and are well tolerated by aspirin-sensitive asthmatics, did not activate their platelets to release cytocidal factors.
Localization (tolerated) of cyclooxygenase in platelets associated with aspirin and occupational lung diseases
9) Confidence 0.09 Published 1985 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 3934085 Disease Relevance 0.62 Pain Relevance 0.85
It has been suggested that indomethacin induces gastric damage via inhibiting the release of protective factors like cyclooxygenase-1 (COX-1), prostaglandin E2 (PGE2), bicarbonate, and mucus; increasing aggressive factors like acid; and increasing oxidant parameters while decreasing antioxidant parameters.
Localization (release) of cyclooxygenase-1 in PGE2
10) Confidence 0.08 Published 2010 Journal Inflammation Section Abstract Doc Link 20084447 Disease Relevance 0.48 Pain Relevance 0.35
LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase.
Localization (forms) of cyclooxygenase
11) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12
An anti-inflammatory effect is believed to result from inhibiting the formation of prostaglandins by prostaglandin H synthase (COX, also called cyclooxygenase), which converts arachidonic acid (AA) released by membrane phospholipids into prostaglandins.
Localization (released) of prostaglandin H synthase associated with inflammation
12) Confidence 0.05 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.64 Pain Relevance 0.50
The expression of adhesion molecules and the release of cyclooxygenase (COX)-derived products by ASM cells may also influence inflammatory processes in the airways.
Localization (release) of cyclooxygenase associated with inflammation and adhesions
13) Confidence 0.05 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.30 Pain Relevance 0.47
Prostaglandin synthesis is regulated at multiple steps, including: (1) phospholipase A2, which releases arachidonic acid from membrane phospholipids; (2) PGH synthase (PGHS), which converts arachidonic acid to the endoperoxides PGG2 and PGH2; and (3) PG synthases convert the endoperoxides to PGI2, PGE2, and others.
Localization (releases) of PGHS
14) Confidence 0.03 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631046 Disease Relevance 0.09 Pain Relevance 0.17
Prostaglandin synthesis is regulated at multiple steps, including: (1) phospholipase A2, which releases arachidonic acid from membrane phospholipids; (2) PGH synthase (PGHS), which converts arachidonic acid to the endoperoxides PGG2 and PGH2; and (3) PG synthases convert the endoperoxides to PGI2, PGE2, and others.
Localization (releases) of PGH synthase
15) Confidence 0.03 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631046 Disease Relevance 0.09 Pain Relevance 0.17
HET0016, a selective inhibitor of CYP4A, suppresses the formation of 20-HETE at a concentration <10 nM, and has no effect on epoxygenase, cyclooxygenase, or lipoxygenase activity at concentrations up to 1 ?
Localization (cyclooxygenase) of cyclooxygenase
16) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.46 Pain Relevance 0.12
The discovery of the two isoenzymes of cyclooxygenase COX-1 and COX-2 and their separate functions, localization and regulation, has initiated the search for new and more selective inhibitors of prostaglandin biosynthesis.
Localization (localization) of cyclooxygenase COX-1
17) Confidence 0.01 Published 2002 Journal Curr Opin Investig Drugs Section Abstract Doc Link 12498012 Disease Relevance 0.37 Pain Relevance 0.42

General Comments

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