INT3926

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Context Info
Confidence 0.61
First Reported 1977
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 16.72
Pain Relevance 16.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
plasma 3
microglia 3
muscle 1
nucleus 1
blood 1
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 757 100.00 Very High Very High Very High
bradykinin 213 100.00 Very High Very High Very High
antagonist 168 100.00 Very High Very High Very High
Inflammation 112 100.00 Very High Very High Very High
agonist 112 100.00 Very High Very High Very High
Pain 82 100.00 Very High Very High Very High
aspirin 12 100.00 Very High Very High Very High
Analgesic 8 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 100.00 Very High Very High Very High
Stress 147 99.68 Very High Very High Very High
Inflammatory Pain 12 99.68 Very High Very High Very High
Pressure And Volume Under Development 96 99.66 Very High Very High Very High
Diabetes Mellitus 329 99.60 Very High Very High Very High
Pain 77 99.56 Very High Very High Very High
INFLAMMATION 120 99.54 Very High Very High Very High
Neuropathic Pain 377 99.36 Very High Very High Very High
Hyperalgesia 104 99.16 Very High Very High Very High
Adhesions 9 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In isolated spontaneously beating right atria taken from drug-treated rats, beta-1 receptor sensitivity (isoproterenol positive chronotrophy) was not affected by the administration of imipramine for 4 days; however, administration of imipramine for 11 days resulted in significant decrease in beta-1 receptor sensitivity.
Neg (not) Regulation (affected) of beta-1 receptor
1) Confidence 0.61 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2868116 Disease Relevance 0.07 Pain Relevance 0.19
Role of kinin B1 and B2 receptors in a rat model of neuropathic pain.
Regulation (Role) of kinin B1 associated with neuropathic pain
2) Confidence 0.61 Published 2008 Journal Int. Immunopharmacol. Section Title Doc Link 18182225 Disease Relevance 0.57 Pain Relevance 0.80
Part of the beneficial effects of SSR240612 appears to be associated with the normalization of B1R gene and protein expression which is dependent on the oxidative stress.



Regulation (dependent) of B1R associated with stress and b1 receptor
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.01 Pain Relevance 0.38
The inhibition and down-regulation of B1R-induced oxidative stress following chronically administered SSR240612 may explain the persistent normalization of high blood pressure, allodynia and insulin resistance in glucose-fed rats.


Regulation (regulation) of B1R in blood associated with stress, pressure and volume under development, allodynia, b1 receptor and insulin resistance
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.83 Pain Relevance 0.55
Thus the inhibition of the oxidative stress by SSR240612 is likely due to the inhibition of the NADPH dependent pro-oxidative effect of B1R activation.
Regulation (effect) of B1R associated with stress and b1 receptor
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.80 Pain Relevance 0.55
Effect of microglia inhibitors and B1R antagonists on allodynia induced by STZ
Regulation (Effect) of B1R in microglia associated with allodynia, antagonist and b1 receptor
6) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.28 Pain Relevance 1.02
The therapeutic effects of B1R antagonists and microglia inhibitors on allodynia and hyperalgesia are unlikely due to changes in blood glucose concentrations since microglia inhibitors and intrathecal B1R antagonist reversed pain neuropathy without affecting hyperglycemia in STZ-diabetic rats.
Regulation (effects) of B1R in microglia associated with hyperglycemia, pain, allodynia, diabetes mellitus, neuropathic pain, hyperalgesia, b1 receptor, antagonist and intrathecal
7) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.61 Pain Relevance 1.58
Effect of T-kinin on microvascular permeability and its modulation by peptidases in rat airways.
Regulation (Effect) of T-kinin associated with qutenza
8) Confidence 0.43 Published 1995 Journal J. Appl. Physiol. Section Title Doc Link 8567553 Disease Relevance 0.18 Pain Relevance 0.42
We examined the effect of T-kinin on vascular permeability in airways of anesthetized rats in vivo by using photometric measurement of the extravasated Evans blue.
Spec (examined) Regulation (effect) of T-kinin
9) Confidence 0.43 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 8567553 Disease Relevance 0.19 Pain Relevance 0.31
This study measured the densities of B1R and B2R binding sites in the spinal cord and dorsal root ganglia (DRG) by quantitative autoradiography, and evaluated the effects of two selective non-peptide antagonists at B1R (LF22-0542) and B2R (LF16-0687) on pain behavior after partial ligation of the left sciatic nerve.
Spec (partial) Regulation (effects) of B1R in sciatic nerve associated with pain, antagonist, sciatic nerve and spinal cord
10) Confidence 0.39 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.44 Pain Relevance 0.63
A key finding of the present study was the demonstration that a one-week treatment with SSR240612 reversed the vascular oxidative stress and normalized B1R up-regulation in glucose-fed rats.
Regulation (regulation) of B1R associated with stress and b1 receptor
11) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.50 Pain Relevance 0.21
The influence of kinin and opioid receptor blockade in the paratrigeminal nucleus (Pa5) on the somatosensory reflex (SSR) to sciatic nerve stimulation (SNS) was assessed in anaesthetized-paralyzed rats.
Regulation (influence) of kinin in nucleus associated with sciatic nerve, opioid receptor and paralysis
12) Confidence 0.32 Published 2005 Journal Peptides Section Abstract Doc Link 15908043 Disease Relevance 0.09 Pain Relevance 0.39
Effect of microglia inhibitors on mRNA levels of B1R, TRPV1, IL-1?
Regulation (Effect) of B1R in microglia associated with b1 receptor
13) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.61 Pain Relevance 0.69
B1R knockout mice are less sensitive to pro-inflammatory pain stimuli, spinal sensitization and diabetic hyperalgesia [14,15].
Regulation (sensitive) of B1R in spinal associated with targeted disruption, hyperalgesia, diabetes mellitus, spinal sensitization, eae and b1 receptor
14) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.82 Pain Relevance 1.48
Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance.
Regulation (Involvement) of kinin B1 receptor associated with stress, pressure and volume under development, congenital anomalies, b1 receptor and insulin resistance
15) Confidence 0.26 Published 2007 Journal Neuropeptides Section Title Doc Link 17988733 Disease Relevance 1.27 Pain Relevance 0.31
Effects of morphine and acetylsalicylic acid on kinin forming enzyme in rat paw.
Regulation (Effects) of kinin in paw associated with aspirin and morphine
16) Confidence 0.23 Published 1977 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 921396 Disease Relevance 0.07 Pain Relevance 0.74
Data suggest that in persistent inflammatory conditions in the rat bradykinin B1 receptors are involved in the accompanying hyperalgesia.
Regulation (involved) of bradykinin B1 associated with hyperalgesia, inflammation and bradykinin
17) Confidence 0.23 Published 1993 Journal Pain Section Abstract Doc Link 8393171 Disease Relevance 1.01 Pain Relevance 1.56
Targeting the bradykinin B1 receptor to reduce pain.
Regulation (Targeting) of bradykinin B1 receptor associated with pain, analgesic and b1 receptor
18) Confidence 0.15 Published 2007 Journal Expert Opin. Ther. Targets Section Title Doc Link 17150032 Disease Relevance 0.47 Pain Relevance 0.80
The effects of enkephalin derivates with different opioid receptor subtype specificity and naloxone on cardiovascular responses and kallikrein-kinin system (KKS) were studied in anesthetized rats exposed to 30% hemorrhage.
Regulation (effects) of kallikrein-kinin associated with narcan, cva, opioid receptor and enkephalin
19) Confidence 0.07 Published 1988 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 3070204 Disease Relevance 0.61 Pain Relevance 0.72
We have recently shown that BK receptor antagonists can upregulate or downregulate specific cell-adhesion molecules [44].
Regulation (upregulate) of BK receptor associated with antagonist, bradykinin and adhesions
20) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175023 Disease Relevance 1.74 Pain Relevance 0.68

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