INT39266

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Context Info
Confidence 0.30
First Reported 1981
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.66
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) cytoplasmic membrane-bounded vesicle (Neu1) plasma membrane (Neu1)
molecular_function (Neu1) cellular_component (Neu1) biological_process (Neu1)
Anatomy Link Frequency
macrophages 3
neutrophils 3
Neu1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 96.80 Very High Very High Very High
Inflammation 26 96.30 Very High Very High Very High
Clonidine 2 95.80 Very High Very High Very High
Arthritis 2 94.00 High High
Pain 6 92.16 High High
Analgesic 9 91.68 High High
Hyperalgesia 6 85.08 High High
carrageenan induced 2 83.16 Quite High
Chronic pancreatitis 1 66.72 Quite High
Osteoarthritis 1 39.92 Quite Low
Disease Link Frequency Relevance Heat
Granuloma 1 100.00 Very High Very High Very High
Pleurisy 1 99.36 Very High Very High Very High
Pressure And Volume Under Development 17 98.40 Very High Very High Very High
INFLAMMATION 24 96.30 Very High Very High Very High
Pancreatitis 4 94.32 High High
Experimental Arthritis 2 94.00 High High
Pain 3 92.16 High High
Syndrome 1 89.12 High High
Ulcers 2 87.32 High High
Erythema 2 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the extracts suppressed the release of beta-glucuronidase, a lysosomal enzyme in rat neutrophils.
Negative_regulation (suppressed) of Localization (release) of lysosomal enzyme in neutrophils
1) Confidence 0.30 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875511 Disease Relevance 0.26 Pain Relevance 0.17
Hyperamylasaemia, pancreatic oedema and activation of trypsinogen in the pancreatic tissue, as well as subcellular redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction, were prevented by infusion of 20 mg/kg.h cetraxate for 2 h before caerulein infusion and throughout the 3.5 h of caerulein infusion (5 micrograms/kg.h).
Negative_regulation (prevented) of Localization (redistribution) of lysosomal enzyme associated with pressure and volume under development
2) Confidence 0.24 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.51 Pain Relevance 0.07
All of them, except clonidine, and in contrast to NSAI drugs, were more potent on PAF-acether edema than on kaolin edema; a possible link between these agents is their ability to increase cyclic AMP levels in the cells and consequently to reduce lysosomal enzyme release.
Negative_regulation (reduce) of Localization (release) of lysosomal enzyme associated with pressure and volume under development, inflammation and clonidine
3) Confidence 0.09 Published 1981 Journal Agents Actions Section Abstract Doc Link 7340441 Disease Relevance 1.85 Pain Relevance 1.13
In in vitro experiments, auranofin did not show any suppression of cyclooxygenase activity, but was capable of suppression of lysosomal enzyme release and chemotaxis of neutrophils and macrophages.
Negative_regulation (suppression) of Localization (release) of lysosomal enzyme in macrophages
4) Confidence 0.02 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3937805 Disease Relevance 0.75 Pain Relevance 0.52
In rats the oral administration of CS significantly decreases granuloma formation due to sponge implants and cell migration and lysosomal enzyme release in carrageenan pleurisy.
Negative_regulation (decreases) of Localization (release) of lysosomal enzyme associated with pleurisy and granuloma
5) Confidence 0.01 Published 1998 Journal Osteoarthr. Cartil. Section Abstract Doc Link 9743814 Disease Relevance 0.54 Pain Relevance 0.18
In in vitro experiments, auranofin did not show any suppression of cyclooxygenase activity, but was capable of suppression of lysosomal enzyme release and chemotaxis of neutrophils and macrophages.
Negative_regulation (suppression) of in neutrophils Localization (release) of lysosomal enzyme in macrophages
6) Confidence 0.01 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3937805 Disease Relevance 0.75 Pain Relevance 0.52

General Comments

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