INT39281

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1)
nucleus (DECR1) cytoplasm (DECR1)
Anatomy Link Frequency
leukocytes 1
microglia 1
DECR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 98.98 Very High Very High Very High
Opioid 2 98.92 Very High Very High Very High
Oxycodone 1 93.00 High High
Buprenorphine 1 91.80 High High
Morphine 4 91.20 High High
methadone 1 82.04 Quite High
opioid receptor 3 75.00 Quite High
Enkephalin 1 44.80 Quite Low
qutenza 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 77.64 Quite High
Stress 1 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the agonist-selective PLD2 activation plays a key role in the regulation of NADH/NADPH-mediated ROS formation by opioids.
Regulation (regulation) of NADPH associated with agonist and opioid
1) Confidence 0.44 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.06 Pain Relevance 0.81
The effects of antibiotics and other commonly used medications on the human polymorphonuclear neutrophil leukocytes' (PMNs) nicotinamide-adenine dinucleotide phosphate-reduced (NADPH) oxidase activity have been investigated in vitro.
Regulation (effects) of NADPH in leukocytes
2) Confidence 0.26 Published 1986 Journal Arch Surg Section Abstract Doc Link 3942501 Disease Relevance 0 Pain Relevance 0.08
Together, our data suggest that TRPV1 channels are involved in regulating NADPH oxidase-mediated ROS generation in microglia.
Regulation (regulating) of NADPH in microglia
3) Confidence 0.26 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19683814 Disease Relevance 0.08 Pain Relevance 0

General Comments

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