INT39282

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 16.89
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
SH-SY5Y 3
macrophage 1
liver 1
MIA PaCa-2 1
neuronal 1
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 136 100.00 Very High Very High Very High
diclofenac 1041 99.98 Very High Very High Very High
qutenza 9 98.48 Very High Very High Very High
Morphine 10 97.92 Very High Very High Very High
Inflammation 87 97.48 Very High Very High Very High
Codeine 6 94.92 High High
Opioid 4 94.48 High High
cINOD 210 87.28 High High
cytokine 60 69.64 Quite High
Cancer pain 2 68.36 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 136 100.00 Very High Very High Very High
Disease 46 100.00 Very High Very High Very High
Stress 155 99.82 Very High Very High Very High
Ureteral Obstruction 50 99.74 Very High Very High Very High
Apoptosis 764 99.16 Very High Very High Very High
Neuroblastoma 133 99.10 Very High Very High Very High
Parkinson's Disease 52 98.96 Very High Very High Very High
Cancer 226 98.08 Very High Very High Very High
Pancreatic Cancer 16 97.70 Very High Very High Very High
INFLAMMATION 125 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, morphine increased the activity of mitochondrial Mn-containing superoxide dismutase (MnSOD) in HL-60 cells, but decreased the MnSOD activity in A549 and MCF7 cells.
Negative_regulation (decreased) of MnSOD in MCF7 associated with morphine
1) Confidence 0.59 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894522 Disease Relevance 0.94 Pain Relevance 0.79
Epidemiologic studies of the MnSOD Ala-9Val polymorphism are difficult to interpret in light of recent data suggesting that the Val allele leads to impaired protein transport and to reduced MnSOD activity, while the Ala allele has normal activity [13].
Negative_regulation (reduced) of MnSOD
2) Confidence 0.58 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.44 Pain Relevance 0.62
However, the increased risk associated with the MnSOD-9Ala allele is difficult to interpret given that the Val allele (but not the Ala allele) is associated with reduced MnSOD enzymatic activity in rat liver model systems [13].
Negative_regulation (reduced) of MnSOD in liver
3) Confidence 0.58 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.45 Pain Relevance 0.16
Indeed, an excessive production of ROS and a decrease in SOD2 levels contribute to the mitochondrial dysfunction.
Negative_regulation (decrease) of SOD2 associated with parkinson's disease
4) Confidence 0.57 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.52 Pain Relevance 0.11
Our data on SH-SY5Y cells show that diclofenac impairs SOD2 functions, thus suggesting that this enzyme is involved in the apoptotic mechanism induced by the drug.
Negative_regulation (impairs) of SOD2 in SH-SY5Y associated with apoptosis and diclofenac
5) Confidence 0.57 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.62 Pain Relevance 0.25
The cell pancreatic cancer lines BxPC-3, MIA PaCa-2, and AsPC-1 had decreased levels of MnSOD immunoreactive protein as well as activity and decreases in MnSOD levels correlated well with increased rates of tumor cell proliferation as determined by cell doubling time.
Negative_regulation (decreases) of MnSOD in MIA PaCa-2 associated with cancer and pancreatic cancer
6) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.68 Pain Relevance 0.05
We also evaluated whether the diclofenac-induced decrease of SOD2 levels/activity depends on a down-regulation of the corresponding mRNA.
Negative_regulation (decrease) of SOD2 associated with diclofenac
7) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0 Pain Relevance 0.27
In fact, in mice a partial deficiency of the SOD2 gene (sod2(+/?))
Negative_regulation (deficiency) of sod2
8) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 1.21 Pain Relevance 0.23
Interestingly, the SOD2 activity decreased in a time-dependent manner (Figure 4), thus indicating that the reduction of the enzyme level caused a lower efficiency in the defence against the superoxide anions.
Negative_regulation (decreased) of SOD2
9) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.06 Pain Relevance 0.29
Our data show that the treatment of the neuroblastoma cell line SH-SY5Y with diclofenac induces a decrease in SOD2 protein level and an increase of the ROS concentration.
Negative_regulation (decrease) of SOD2 protein in SH-SY5Y associated with neuroblastoma and diclofenac
10) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.95 Pain Relevance 0.17
Diclofenac decreased the protein levels and the enzymatic activity of SOD2, without any significant impairment of the corresponding mRNA levels in the SH-SY5Y extracts.
Negative_regulation (decreased) of SOD2 in SH-SY5Y associated with diclofenac
11) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2896885 Disease Relevance 0.76 Pain Relevance 0.29
To investigate the possibility that the reduction of the SOD2 protein levels corresponded also to a decrease in SOD activity, the protein extracts obtained from cells incubated with 150??
Negative_regulation (reduction) of SOD2 protein
12) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.07 Pain Relevance 0.28
In fact, in mice a partial deficiency of the SOD2 gene (sod2(+/?))
Negative_regulation (deficiency) of SOD2 gene
13) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 1.21 Pain Relevance 0.23
In particular, this process is associated to a significant and concomitant reduction of both protein level and enzymatic activity of SOD2, whereas RT-PCR experiments showed that the corresponding mRNA levels are not affected by the diclofenac treatment.
Negative_regulation (reduction) of SOD2 associated with diclofenac
14) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.48 Pain Relevance 0.27
The decrease of SOD2 levels (Figure 3(b)) was evident after 24-hour treatment and increased at 48 hours.
Negative_regulation (decrease) of SOD2
15) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.07 Pain Relevance 0.26
When these neuronal cells were incubated for 24 hours with increasing diclofenac concentrations, a dose-dependent decrease of the SOD2 protein level was observed, as evaluated by Western blotting using antibodies against human SOD2 (Figure 3(a)).
Negative_regulation (decrease) of SOD2 protein in neuronal associated with diclofenac
16) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.14 Pain Relevance 0.36
To this aim, the effect of TrxA2 from the hyperthermophilic archaeon Sulfolobus solfataricus (SsTrx) on the reduction of SOD2 levels caused by diclofenac was evaluated (Figure 6).
Negative_regulation (reduction) of SOD2 associated with diclofenac
17) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.09 Pain Relevance 0.25
The superoxide dismutase-inhibitable, NADPH-dependent reduction of cytochrome C in the PMNs was studied after stimulation with formyl-methionyl-leucine-phenylalanine.
Negative_regulation (reduction) of superoxide dismutase
18) Confidence 0.41 Published 1986 Journal Arch Surg Section Abstract Doc Link 3942501 Disease Relevance 0 Pain Relevance 0.17
On the other hand, the antioxidant enzyme superoxide dismutase 2 (SOD2) was significantly decreased by both drugs and synergistically by their combination, thus suggesting a drug-induced decrease of the oxidative stress caused by IL-1?
Negative_regulation (decreased) of SOD2 associated with stress
19) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945029 Disease Relevance 0.37 Pain Relevance 0.10
A decrease in SOD2 protein levels was evident in all donors (n = 7, age range: 51 to 72 years old).
Negative_regulation (decrease) of SOD2
20) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.16 Pain Relevance 0.04

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