INT3933

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2010
Negated 9
Speculated 0
Reported most in Abstract
Documents 128
Total Number 129
Disease Relevance 30.76
Pain Relevance 42.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 21
follicle 8
gonadal 4
pituitary 3
liver 1
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 381 100.00 Very High Very High Very High
agonist 270 100.00 Very High Very High Very High
Dopamine 17 100.00 Very High Very High Very High
Buprenorphine 6 100.00 Very High Very High Very High
withdrawal 39 99.96 Very High Very High Very High
antagonist 258 99.88 Very High Very High Very High
Opioid 109 99.76 Very High Very High Very High
ketamine 6 99.68 Very High Very High Very High
Locus ceruleus 1 99.64 Very High Very High Very High
opiate 91 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 12 100.00 Very High Very High Very High
Hypogonadotropic Hypogonadism 172 99.92 Very High Very High Very High
Endometriosis (extended) 254 99.74 Very High Very High Very High
Polycystic Ovary Syndrome 160 99.72 Very High Very High Very High
Obesity 146 99.48 Very High Very High Very High
Reprotox - General 2 83 99.18 Very High Very High Very High
Frailty 17 99.12 Very High Very High Very High
Precocious Puberty 14 98.80 Very High Very High Very High
Disease 91 98.48 Very High Very High Very High
Mumps 89 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, naloxone caused a significant increase in plasma LH levels in fertile women during the luteal phase of the cycle, but not during the follicular phase or in postmenopausal subjects, and in young but not in aged men (P less than 0.01).
Positive_regulation (increase) of LH in plasma associated with narcan
1) Confidence 0.70 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.22 Pain Relevance 0.91
Naloxone fails to increase LH levels in clomiphene treated men.
Neg (fails) Positive_regulation (increase) of LH associated with narcan
2) Confidence 0.70 Published 1984 Journal Horm. Metab. Res. Section Title Doc Link 6425183 Disease Relevance 0 Pain Relevance 0.43
Before clomiphene treatment, naloxone caused a significant increase in LH levels, however, after clomiphene, naloxone failed to induce the same effect.
Positive_regulation (increase) of LH associated with narcan
3) Confidence 0.70 Published 1984 Journal Horm. Metab. Res. Section Abstract Doc Link 6425183 Disease Relevance 0 Pain Relevance 0.32
In addition, the naloxone infusion induced a significant (P less than 0.05) increase in plasma LH levels, which reached values similar to those before veralipride administration.
Positive_regulation (increase) of LH in plasma associated with narcan
4) Confidence 0.70 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.41
Acute naltrexone administration did not alter T levels appreciably but was associated with a significant elevation in LH levels.
Positive_regulation (elevation) of LH
5) Confidence 0.70 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.26 Pain Relevance 0.40
OBJECTIVES: Since short-term opioid antagonism increases LH pulsatility during the luteal phase in women, we postulated that prolonged opioid antagonism may also accelerate the LH secretory episodes at this time.
Positive_regulation (increases) of LH associated with opioid
6) Confidence 0.69 Published 1998 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 9861326 Disease Relevance 0 Pain Relevance 0.27
After fenfluramine, naloxone infusion failed to induce any increase in LH plasma levels; metergoline pretreatment significantly enhanced the naloxone-induced LH increase.
Positive_regulation (increase) of LH in plasma associated with narcan
7) Confidence 0.69 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.70
GnRH injection consistently increased plasma LH levels in healthy subjects as well as in the children with pubertal disturbances.
Positive_regulation (increased) of LH in plasma
8) Confidence 0.69 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3531220 Disease Relevance 0.68 Pain Relevance 0.25
In healthy subjects, NLX significantly increased plasma LH levels only in girls and boys at the most advanced stage of gonadal maturation.
Positive_regulation (increased) of LH in gonadal
9) Confidence 0.69 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3531220 Disease Relevance 0.64 Pain Relevance 0.21
The evidence that naloxone, an opiate receptor blockade, increases LH levels suggests a tonic inhibitory action of EOP.
Positive_regulation (increases) of LH associated with narcan and opiate
10) Confidence 0.68 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2689783 Disease Relevance 0.17 Pain Relevance 0.59
The naloxone-induced LH increase is not observed before pubertal maturation, in both sexes, and is absent in children with delayed or precocious puberty and in those with Klinefelter's or Turner's syndrome, suggesting a role of gonadal function on the opioid control of LH secretion.
Positive_regulation (increase) of LH in gonadal associated with precocious puberty, syndrome, narcan and opioid
11) Confidence 0.68 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2689783 Disease Relevance 0.19 Pain Relevance 0.60
A significant increase in both bio and immuno active LH was observed in all subjects after 15-30 min (p less than 0.05 to p less than 0.001), reaching maximal levels at 30-60 min for both forms of the hormone.
Positive_regulation (increase) of LH
12) Confidence 0.68 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.36
Naloxone increases bioactive LH in man: evidence for selective release of early LH pool.
Positive_regulation (increases) of LH associated with narcan
13) Confidence 0.68 Published 1985 Journal J. Endocrinol. Invest. Section Title Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.47
Opioid peptides inhibit LH secretion and the opiate antagonist naloxone provokes increases in plasma LH levels by release of endogenous GnRH from the hypothalamus.
Positive_regulation (increases) of LH in hypothalamus associated with antagonist, narcan, opiate and opioid
14) Confidence 0.68 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.41
Naloxone infusion alone significantly increased mean LH levels and LH pulse frequency in patients in group III, and this was also blocked by VPA pretreatment.
Positive_regulation (increased) of LH associated with narcan
15) Confidence 0.68 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.44
Our findings can be summarized: 1) during pubertal maturation there is a change in amplitude but not frequency of gonadotropin pulses, 2) pubertal development of the hypothalamic-pituitary axis advances in the absence of gonadal feedback, and 3) there is a significant increase in the LH bioassay: RIA during pubertal development.
Positive_regulation (increase) of LH in gonadal
16) Confidence 0.67 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6404922 Disease Relevance 0 Pain Relevance 0.06
Melatonin did not affected LH serum levels, while it was able to reduce LH increase induced by naloxone.
Positive_regulation (increase) of LH associated with narcan
17) Confidence 0.66 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3361078 Disease Relevance 0 Pain Relevance 0.70
In fertile women, naloxone administration increases LH levels in the luteal phase but not in the follicular phase.
Positive_regulation (increases) of LH associated with narcan
18) Confidence 0.63 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.29
In the postmenopausal period, naloxone has no effect on LH release; estrogen/progestin therapy does restore the LH response.
Positive_regulation (restore) of LH associated with narcan
19) Confidence 0.63 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.28
Naloxone caused a significant increase in luteinizing hormone (LH) (P less than 0.05); in these subjects, clomiphene treatment significantly increased LH and follicle-stimulating hormone plasma levels but totally suppressed the naloxone-induced rise in LH.
Positive_regulation (increase) of LH in plasma associated with narcan
20) Confidence 0.63 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.53

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