INT39330

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Context Info
Confidence 0.26
First Reported 1983
Last Reported 2003
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfs) Golgi apparatus (Mthfs) ligase activity (Mthfs)
cytoplasm (Mthfs) plasma membrane (Mthfs) molecular_function (Mthfs)
Anatomy Link Frequency
spinal 2
PGE2 2
Mthfs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 99.74 Very High Very High Very High
aspirin 7 97.50 Very High Very High Very High
pain labor 1 91.76 High High
cINOD 4 83.16 Quite High
dexamethasone 2 76.00 Quite High
Dorsal horn neuron 1 75.00 Quite High
Spinal cord 1 75.00 Quite High
diclofenac 1 42.12 Quite Low
acular 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 99.74 Very High Very High Very High
Labor Pain 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attempts to determine whether co-administration of NSAI drugs might reduce the inhibition of PG cyclo-oxygenase by more potent inhibitors (e.g. indomethacin) have been explored as a means for reducing the gastric ulcerogenicity of the latter.
Spec (might) Negative_regulation (reduce) of Negative_regulation (inhibition) of cyclo-oxygenase associated with inflammation
1) Confidence 0.26 Published 1986 Journal Int J Tissue React Section Abstract Doc Link 3949439 Disease Relevance 0.33 Pain Relevance 0.30
The authors examined uterine cervical distension-evoked cFos immunoreactivity in rat spinal cords, and the inhibitory effect of spinal cyclo-oxygenase inhibition on cFos expression.
Spec (examined) Negative_regulation (effect) of Negative_regulation (inhibition) of cyclo-oxygenase in spinal
2) Confidence 0.02 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12826861 Disease Relevance 0.09 Pain Relevance 0.17
Aspirin also reduced the levels of PGE2 and TXB2 in the exudate but did not consistently affect PMN influx, thereby confirming that inhibition of cyclo-oxygenase does not reduce cell migration in inflammation.
Neg (not) Negative_regulation (reduce) of Negative_regulation (inhibition) of cyclo-oxygenase in PGE2 associated with aspirin and inflammation
3) Confidence 0.01 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6141244 Disease Relevance 0.40 Pain Relevance 0.48

General Comments

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