INT39344

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Context Info
Confidence 0.54
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.25
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNASE1L3) DNA binding (DNASE1L3) DNA metabolic process (DNASE1L3)
Anatomy Link Frequency
HeLa 2
urines 2
neurons 1
DNASE1L3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 24 98.84 Very High Very High Very High
Serotonin 66 98.42 Very High Very High Very High
Raphe 7 98.12 Very High Very High Very High
melanocortin 1 receptor 5 90.60 High High
antagonist 3 88.72 High High
agonist 22 88.16 High High
fluoxetine 6 70.56 Quite High
Neurotransmitter 25 66.72 Quite High
monoamine 28 66.00 Quite High
Potency 14 61.16 Quite High
Disease Link Frequency Relevance Heat
Unconsciousness 56 98.84 Very High Very High Very High
Death 5 96.08 Very High Very High Very High
Syndrome 2 92.44 High High
Targeted Disruption 2 90.96 High High
Hallucination 34 85.84 High High
Apoptosis 10 85.00 Quite High
Reprotox - General 1 2 71.96 Quite High
Adenocarcinoma 2 64.00 Quite High
Hearing Disorder 5 57.96 Quite High
Poisoning 20 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNAS1L3 expression potentiated the cytotoxic effect of acetaminophen in HeLa cells suggesting an active role in the death process induced by this drug.
Gene_expression (expression) of DNAS1L3 in HeLa associated with paracetamol and death
1) Confidence 0.54 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.51 Pain Relevance 0.83
The treatment of HeLa cells with acetaminophen resulted in internuclesomal DNA fragmentation only after transfection of these cells with a plasmid encoding the DNAS1L3 gene suggesting that this endonuclease is required for acetaminophen-induced internucleosomal DNA fragmentation.
Gene_expression (transfection) of DNAS1L3 in HeLa associated with paracetamol
2) Confidence 0.53 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.58 Pain Relevance 0.90
Co-administration of the serotonin receptor blockers, metergoline or mianserin, with lysergic acid diethylamide (LSD) produced no change in the inhibitory effects of LSD on raphe neurons, but produced a dose-dependent blockade of the behavioral effects of LSD in the cat.
Neg (no) Gene_expression (produced) of LSD in neurons associated with raphe and serotonin
3) Confidence 0.50 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3952126 Disease Relevance 0 Pain Relevance 0.61
123.9), by the squares of the values in the center column (“Bsq”) of Table 3 (for LSD, 13.122?
Gene_expression (for) of LSD
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814854 Disease Relevance 0 Pain Relevance 0.03
Furthermore, almost nothing is known regarding the contribution of specific drug-metabolizing enzyme to the production of individual LSD metabolites in humans.
Gene_expression (production) of LSD
5) Confidence 0.24 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
Serotonergic hallucinogens —such as LSD, mescaline, and psilocybin— produce a bewildering variety of visual phenomena [1]–[7].
Gene_expression (produce) of LSD
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996283 Disease Relevance 0.39 Pain Relevance 0
Thus, significant difference in LSD metabolism between humans and laboratory animals has been observed.
Gene_expression (metabolism) of LSD
7) Confidence 0.21 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
LSD is extensively metabolized in laboratory animals and only a trivial fraction of the parent drug is excreted in urine.
Gene_expression (metabolized) of LSD in urine
8) Confidence 0.21 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.17 Pain Relevance 0.07
Major metabolites of LSD detected in the rat and guinea pig urines were the 13- and 14-hydroxy-LSD (HO-LSD) and their corresponding glucuronic acid conjugates (54).
Gene_expression (detected) of LSD in urines
9) Confidence 0.19 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.05 Pain Relevance 0.06
This finding suggests that 2-oxo-3-HO-LSD could be produced through dehydrogenation of the 2,3-dihydroxy-LSD intermediate, which is presumably formed from LSD 2,3-epoxide.
Gene_expression (produced) of HO-LSD
10) Confidence 0.19 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
If we could stimulate the primary psychical process in waking we would have a more effective method for studying the unconscious:

'Freud once said of dreams that they were the via regia or royal way to study the unconscious; to an even greater degree this seems to be true for the LSD experience' [265].

Gene_expression (experience) of LSD associated with unconsciousness
11) Confidence 0.17 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.55 Pain Relevance 0
The mutant receptor DNAs were transiently expressed in COS-1 cells and their ability to bind [N1e4,D-Phe7]-alpha-MSH (NDP-MSH) was evaluated.
Gene_expression (expressed) of DNAs
12) Confidence 0.08 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.39

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