INT39394

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Context Info
Confidence 0.45
First Reported 1980
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.83
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 7
glomerulus 1
kidney 1
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 3 100.00 Very High Very High Very High
Clonidine 19 99.84 Very High Very High Very High
withdrawal 4 91.00 High High
alcohol 3 90.56 High High
Analgesic 2 90.04 High High
transdermal 4 87.96 High High
fibrosis 2 76.24 Quite High
beta blocker 2 74.20 Quite High
anesthesia 3 70.52 Quite High
ketamine 1 69.88 Quite High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 64 99.84 Very High Very High Very High
Targeted Disruption 14 99.66 Very High Very High Very High
Hypertension 34 99.34 Very High Very High Very High
Natriuresis 2 99.28 Very High Very High Very High
Coronary Artery Disease 30 99.08 Very High Very High Very High
Pheochromocytoma 6 97.12 Very High Very High Very High
Hypotension 2 95.88 Very High Very High Very High
Convulsion 7 93.84 High High
Cardiovascular Disease 6 93.44 High High
Erythema 1 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis.
Regulation (regulation) of renin
1) Confidence 0.45 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0 Pain Relevance 0.09
Plasma renin activity was unchanged in both groups.
Neg (unchanged) Regulation (unchanged) of Plasma renin in Plasma
2) Confidence 0.41 Published 1983 Journal Chest Section Abstract Doc Link 6337029 Disease Relevance 0.52 Pain Relevance 0.47
Clonidine might reduce blood pressure by inhibiting sympathetic outflow, and any effect on plasma renin activity appears unimportant in its antihypertensive action.
Regulation (effect) of plasma renin in plasma associated with clonidine
3) Confidence 0.41 Published 1983 Journal Chest Section Abstract Doc Link 6337029 Disease Relevance 0.47 Pain Relevance 0.54
The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.
Regulation (influence) of renin-angiotensin-aldosterone-system associated with hypertension
4) Confidence 0.27 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0.10 Pain Relevance 0.07
Drug effects on plasma renin activity in the mouse.
Regulation (effects) of renin in plasma
5) Confidence 0.24 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.11
Sequential determinations of plasma renin activity and catecholamine levels showed no significant alterations in either.
Neg (no) Regulation (alterations) of plasma renin in plasma associated with catecholamine
6) Confidence 0.17 Published 1984 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6607387 Disease Relevance 0.13 Pain Relevance 0.05
Role of the renin-angiotensin-aldosterone system in chronic kidney disease
Regulation (Role) of renin-angiotensin-aldosterone system in kidney associated with chronic renal failure
7) Confidence 0.15 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.02 Pain Relevance 0.04
In contrast, EP4 receptor mRNA is predominantly expressed in the glomerulus, where it may contribute to the regulation of glomerular hemodynamics and renin release.
Regulation (regulation) of renin in glomerulus
8) Confidence 0.14 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.11
Regulation of the renin┬ľangiotensin system in coronary atherosclerosis: A review of the literature

Activation of the renin┬ľangiotensin system (RAS) is significant in the pathogenesis of cardiovascular disease and specifically coronary atherosclerosis.

Regulation (Regulation) of renin associated with coronary artery disease and cardiovascular disease
9) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Title Doc Link PMC2350139 Disease Relevance 0.58 Pain Relevance 0
Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity.
Regulation (role) of plasma renin in plasma associated with targeted disruption and hypertension
10) Confidence 0.09 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9458926 Disease Relevance 0.58 Pain Relevance 0.16
function and indirectly through the regulation of renin-angiotensin system
Regulation (regulation) of renin-angiotensin
11) Confidence 0.08 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
Plasma renin, vasopressin, and epinephrine levels were not modified by clonidine, whereas plasma norepinephrine level was significantly reduced.
Neg (not) Regulation (modified) of Plasma renin in plasma associated with clonidine
12) Confidence 0.02 Published 1985 Journal JAMA Section Abstract Doc Link 3965774 Disease Relevance 0.34 Pain Relevance 0.59
There was no significant change in levels of growth hormone, luteinizing hormone, follicular stimulating hormone, or plasma renin activity.
Neg (no) Regulation (change) of plasma renin in plasma
13) Confidence 0.00 Published 1984 Journal Brain Section Abstract Doc Link 6144354 Disease Relevance 0.64 Pain Relevance 0.16

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