INT39406

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 37.80
Pain Relevance 7.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (OLR1) extracellular region (OLR1) cell adhesion (OLR1)
plasma membrane (OLR1)
Anatomy Link Frequency
plasma 5
coronary artery 3
macrophages 2
endothelial cells 2
plaque 2
OLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 107 99.70 Very High Very High Very High
Osteoarthritis 212 99.50 Very High Very High Very High
rheumatoid arthritis 203 97.36 Very High Very High Very High
Inflammation 376 95.92 Very High Very High Very High
cytokine 38 94.44 High High
Inflammatory mediators 10 93.32 High High
methotrexate 41 90.68 High High
abatacept 1 87.88 High High
corticosteroid 13 87.72 High High
Pain 114 86.56 High High
Disease Link Frequency Relevance Heat
Rupture 22 100.00 Very High Very High Very High
Hyperlipidemia 23 99.96 Very High Very High Very High
Nicotine Addiction 170 99.84 Very High Very High Very High
Myocardial Infarction 133 99.74 Very High Very High Very High
Cv General 3 Under Development 82 99.70 Very High Very High Very High
Rheumatic Diseases 7 99.64 Very High Very High Very High
Atherosclerosis 417 99.60 Very High Very High Very High
Osteoarthritis 212 99.50 Very High Very High Very High
Disorder Of Lipid Metabolism 345 99.40 Very High Very High Very High
Thrombosis 22 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the atherosclerotic plaque from a patient with unstable angina pectoris (UAP) revealed accumulation of LOX-1 protein at the site of thrombus.
Positive_regulation (accumulation) of LOX-1 protein in plaque associated with atherosclerotic plaque, angina and thrombosis
1) Confidence 0.70 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11263985 Disease Relevance 0.40 Pain Relevance 0.20
formation, either through activating the lectin-like receptor LOX-112 or increasing the production and concentration of asymmetric dimethyl L-arginine.13 The latter is an endogenous inhibitor of nitric oxide synthase and increases oxidative stress.14
Positive_regulation (activating) of LOX associated with stress
2) Confidence 0.67 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.11 Pain Relevance 0.11
A study involving apparently healthy, atherosclerosis-free individuals, with ages ranging from 35 to 55 years, found an association between high oxLDL blood levels and the presence of plaques, or at least intimal thickening, in the femoral arteries.31 Another trial demonstrated that the oxidized phospholipids/apolipoprotein B ratio was strongly and significantly associated with the presence, extent and development of carotid and femoral atherosclerosis and predicted the presence of symptomatic cardiovascular disease.32 Taken together, these two studies show that elevated plasma oxLDL levels may either appear before the disease becomes clinically evident or be strong predictors of the worsening of the disease in the future.
Positive_regulation (elevated) of oxLDL in thickening associated with cardiovascular disease, atherosclerosis, disease and disorder of lipid metabolism
3) Confidence 0.54 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.96 Pain Relevance 0
To verify that tamoxifen treatment of Rac1 flox/flox PDGFB-iCreER endothelial cells induced Rac1-deletion, endothelial cells and non-endothelial cells were isolated from Rac1 flox/flox PDGFB-iCreER mice and treated with tamoxifen (OHT) or ethanol (vehicle) in culture.
Positive_regulation (induced) of lox in endothelial cells
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.58 Pain Relevance 0
The autopsied patient who died of AMI revealed an increased plasma level of ox-LDL, and immunohistochemically, the culprit coronary lesion contained abundant macrophage-derived foam cells, showing distinct positivity for ox-LDL and CD 36.
Positive_regulation (increased) of ox-LDL in foam cells associated with myocardial infarction
5) Confidence 0.47 Published 2002 Journal J. Diabetes Complicat. Section Abstract Doc Link 11872369 Disease Relevance 1.92 Pain Relevance 0.83
The present study shows that the decreased oxLDL and oxLDL-ab and the elevated oxLDL-lgM serum levels may relate to the development and progression of ESSC.



Positive_regulation (elevated) of oxLDL associated with basal and squamous cell skin cancer
6) Confidence 0.44 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2775732 Disease Relevance 0.71 Pain Relevance 0
The level of oxLDL-lgM increased gradually along with esophageal carcinoma progression.
Positive_regulation (increased) of oxLDL associated with esophageal cancer
7) Confidence 0.44 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2775732 Disease Relevance 0.85 Pain Relevance 0
Indeed, the work from Piarulli et al. demonstrated that plasma oxLDL levels were increased just among the longstanding diabetes patients.
Positive_regulation (increased) of oxLDL in plasma associated with diabetes mellitus
8) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.01 Pain Relevance 0
There is also evidence that plasma oxLDL levels is increased in acute coronary syndrome34 and that these increased levels may have a relationship with the severity and the timing of that ischemic event.
Positive_regulation (increased) of oxLDL in plasma
9) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.92 Pain Relevance 0.12
In subjects with familial hyperlipidemia, elevated blood oxLDL and LDL-cholesterol levels were associated with increased carotid intimal-media thickness.23 In two other studies, elevated plasma oxLDL levels were associated with increased carotid intimal-media thickness in asymptomatic subjects whose relatives had familial hypercholesterolemia and also in asymptomatic middle-aged males.24,25
Positive_regulation (elevated) of oxLDL in plasma associated with hyperlipoproteinemia type ii and hyperlipidemia
10) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.62 Pain Relevance 0
CONCLUSIONS: The data suggest that the activation of NF-kB in monocytes of UA patients is, at least in part, induced by circulating molecules such as ox-LDL, which has been found to be particularly elevated in UA patients.


Positive_regulation (elevated) of ox-LDL in monocytes
11) Confidence 0.35 Published 2005 Journal J. Am. Coll. Cardiol. Section Body Doc Link 16139128 Disease Relevance 0 Pain Relevance 0
In subjects with familial hyperlipidemia, elevated blood oxLDL and LDL-cholesterol levels were associated with increased carotid intimal-media thickness.23 In two other studies, elevated plasma oxLDL levels were associated with increased carotid intimal-media thickness in asymptomatic subjects whose relatives had familial hypercholesterolemia and also in asymptomatic middle-aged males.24,25
Positive_regulation (elevated) of oxLDL in plasma associated with hyperlipoproteinemia type ii and hyperlipidemia
12) Confidence 0.32 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.62 Pain Relevance 0
Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina.
Positive_regulation (increase) of oxidized low-density lipoprotein in plasma associated with angina
13) Confidence 0.31 Published 2005 Journal J. Am. Coll. Cardiol. Section Title Doc Link 16139128 Disease Relevance 0.10 Pain Relevance 0.27
However, the plasma level of sLOX-1, a marker of plaque rupture, did not increase during hospitalization.
Neg (not) Positive_regulation (increase) of sLOX-1 in plaque associated with rupture
14) Confidence 0.28 Published 2009 Journal J Nihon Med Sch Section Abstract Doc Link 19915312 Disease Relevance 1.17 Pain Relevance 0.09
The main finding of the present study was the descensive oxLDL-lgG and elevated oxLDL-lgM serum levels in patients with AML compared with normal controls after controlled potential confounders by the covariance analysis model.
Positive_regulation (elevated) of oxLDL associated with acute myeloid leukemia
15) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.19 Pain Relevance 0
The main finding of the present study was the descensive oxLDL-lgG and elevated oxLDL-lgM serum levels in patients with AML compared with normal controls after controlled potential confounders by the covariance analysis model.
Positive_regulation (elevated) of oxLDL-lgM associated with acute myeloid leukemia
16) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.19 Pain Relevance 0
In the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML.
Positive_regulation (elevated) of oxLDL-lgM associated with acute myeloid leukemia
17) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2834680 Disease Relevance 0.50 Pain Relevance 0
In contrast, there were both elevated oxLDL-lgG and descensive oxLDL-lgM serum levels in patients with cardiovascular or cerebrovascular diseases in the reported literature [3].
Positive_regulation (elevated) of oxLDL associated with disease
18) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.16 Pain Relevance 0
The present study shows that in contrast with the detecting antibodies of oxLDL-lgG and oxLDL-lgM serum levels in patients with cardiovascular and cerebrovascular diseases in literature, the descensive oxLDL-lgG and the elevated oxLDL-lgM serum levels may be related to the development and progression of adult AML.
Positive_regulation (elevated) of oxLDL-lgM associated with acute myeloid leukemia and disease
19) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.12 Pain Relevance 0
In contrast, there were both elevated oxLDL-lgG and descensive oxLDL-lgM serum levels in patients with cardiovascular or cerebrovascular diseases in the reported literature [3].
Positive_regulation (elevated) of oxLDL-lgM associated with disease
20) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.17 Pain Relevance 0

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