INT39407

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 14.79
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (OLR1) extracellular region (OLR1) cell adhesion (OLR1)
plasma membrane (OLR1)
Anatomy Link Frequency
platelets 4
plasma 2
plaques 2
coronary artery 1
OLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 39 97.04 Very High Very High Very High
Inflammation 177 94.44 High High
imagery 60 91.20 High High
Restless leg syndrome 9 71.56 Quite High
ischemia 19 69.28 Quite High
tetrodotoxin 1 65.04 Quite High
cytokine 36 64.92 Quite High
rheumatoid arthritis 92 56.72 Quite High
cva 11 47.84 Quite Low
Rheumatism 1 46.28 Quite Low
Disease Link Frequency Relevance Heat
Thrombosis 33 99.80 Very High Very High Very High
Coronary Artery Disease 42 99.76 Very High Very High Very High
Acute Myeloid Leukemia 75 99.00 Very High Very High Very High
Disease 120 98.40 Very High Very High Very High
Atherosclerosis 263 97.32 Very High Very High Very High
Cv General 3 Under Development 36 97.04 Very High Very High Very High
Stable Angina Pectoris 10 96.76 Very High Very High Very High
Disorder Of Lipid Metabolism 195 96.32 Very High Very High Very High
Adhesions 22 96.28 Very High Very High Very High
Hypertension 36 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistently, the activation-dependent binding of OxLDL to platelets was mostly inhibited by anti-LOX-1 antibody.
OxLDL Binding (binding) of in platelets
1) Confidence 0.48 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11263985 Disease Relevance 0.35 Pain Relevance 0.18
As LOX-1 recognizes and binds activated platelets, exposure of LOX-1 on activated platelets surface might assist thrombosis formation.
LOX-1 Spec (might) Binding (binds) of in platelets associated with thrombosis
2) Confidence 0.48 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11263985 Disease Relevance 0.49 Pain Relevance 0.19
As LOX-1 recognizes and binds activated platelets, exposure of LOX-1 on activated platelets surface might assist thrombosis formation.
LOX-1 Spec (might) Binding (recognizes) of in platelets associated with thrombosis
3) Confidence 0.48 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11263985 Disease Relevance 0.49 Pain Relevance 0.19
According to the manufacturer's instructions, using coated microtitration strips 96 wells, plasma was diluted 1:1 and incubated at room temperature for 1 hr in plates precoated with ADP, oxLDL, oxLDL-ab, oxLDL-lgG, or oxLDL-lgM, respectively.
oxLDL Binding (precoated) of in plasma
4) Confidence 0.35 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.41 Pain Relevance 0
According to the manufacturer's instructions, using coated microtitration strips 96 wells, plasma was diluted 1:1 and incubated at room temperature for 1 hr in plates precoated with ADP, oxLDL, oxLDL-ab, oxLDL-lgG, or oxLDL-lgM, respectively.
oxLDL Binding (precoated) of in plasma
5) Confidence 0.35 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.41 Pain Relevance 0
Carotid plaques that were removed with endarterectomy and considered vulnerable and unstable plaques after pathology studies presented a much greater content of oxLDL than stable carotid plaques.20 Furthermore, another study showed that such content was significantly decreased after treatment with statins.21 In addition, oxLDL plasma levels correlate with the incidence of angiographically complex coronary plaques.22
oxLDL Binding (content) of in plaques
6) Confidence 0.29 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.87 Pain Relevance 0.03
Moreover, oxLDL was also associated with the presence, extent, and interim development of carotid and femoral atherosclerosis over a five-year period.
oxLDL Binding (associated) of associated with atherosclerosis
7) Confidence 0.28 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.12 Pain Relevance 0.09
OxLDL was associated with carotid intimal-media thickness, unstable plaques in the coronary and carotid arteries, impaired brachial and coronary endothelial function, and coronary artery disease.
OxLDL Binding (associated) of in plaques associated with coronary artery disease
8) Confidence 0.28 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.03 Pain Relevance 0.11
The results were expressed as the ratio of antibody binding to various types of oxLDL versus LDL [19,20].


oxLDL Binding (binding) of
9) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 0.28 Pain Relevance 0.03
Later on, reports suggested that oxidized LDL (oxLDL, an atherogenic lipid) played a major role in the pathogenesis of atherosclerosis.
oxLDL Binding (oxidized) of associated with atherosclerosis
10) Confidence 0.12 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.66 Pain Relevance 0.11
Determination of serum oxLDL, oxLDL-lgG, and oxLDL-lgM
oxLDL Binding (serum) of
11) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 0.82 Pain Relevance 0.05
Determination of serum oxLDL, oxLDL-lgG, and oxLDL-lgM
oxLDL Binding (serum) of
12) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 0.82 Pain Relevance 0.05
Is IgG anti-oxLDL thought as a cause linkage with the development of AML biology and leukemogenesis?
oxLDL Binding (linkage) of associated with acute myeloid leukemia
13) Confidence 0.08 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2834680 Disease Relevance 1.40 Pain Relevance 0
Meanwhile, various interactions between Ang II and oxLDL have been demonstrated especially by the Keidar group.
oxLDL Binding (interactions) of
14) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.85 Pain Relevance 0.08
Our findings demonstrate the presence of oxLDL in vivo, its strong association with coronary artery disease as well as with the severity of the clinical presentation.
oxLDL Binding (association) of in coronary artery associated with coronary artery disease
15) Confidence 0.06 Published 2005 Journal Free Radic. Res. Section Abstract Doc Link 16028367 Disease Relevance 1.47 Pain Relevance 1.12
Oxidized low-density lipoprotein and antibody determinations
Oxidized low-density lipoprotein Binding (determinations) of
16) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453753 Disease Relevance 0.36 Pain Relevance 0
One of the pathophysiological consequences of platelet binding to LOX-1 may be the inactivation of nitric oxide (NO) through increased cellular production of O2 [75].
LOX-1 Binding (binding) of in platelet
17) Confidence 0.04 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.11 Pain Relevance 0.06
Due to the heterogeneity of oxLDL and the available epitopes that are recognized by the various antibodies, a number of different immunoassays are available for oxLDL, and the correlation among these measurements is quite poor [30].
oxLDL Binding (recognized) of
18) Confidence 0.04 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.46 Pain Relevance 0
Due to the heterogeneity of oxLDL and the available epitopes that are recognized by the various antibodies, a number of different immunoassays are available for oxLDL, and the correlation among these measurements is quite poor [30].
oxLDL Binding (recognized) of
19) Confidence 0.03 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.49 Pain Relevance 0
The robust 5-Loxin -sensitive candidate genes were then subjected to further processing which led to the recognition of the primary 5-Loxin -sensitive TNF?
5-Loxin Binding (recognition) of
20) Confidence 0.02 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697755 Disease Relevance 0.91 Pain Relevance 0.14

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