INT39413

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.57
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNRPB) nucleoplasm (SNRPB) mRNA processing (SNRPB)
nucleus (SNRPB) cytoplasm (SNRPB)
Anatomy Link Frequency
skin 1
upper 1
SNRPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 13 100.00 Very High Very High Very High
antagonist 2 99.44 Very High Very High Very High
psoriasis 3 97.16 Very High Very High Very High
Morphine 1 95.28 Very High Very High Very High
Enkephalin 12 93.72 High High
agonist 2 93.44 High High
excitatory amino acid 2 92.76 High High
narcan 2 89.04 High High
GABAergic 6 87.00 High High
Pain 4 84.32 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 99.68 Very High Very High Very High
Leukemia 3 99.64 Very High Very High Very High
Blister 42 99.60 Very High Very High Very High
Nicotine Addiction 4 99.56 Very High Very High Very High
Skin Diseases 3 98.28 Very High Very High Very High
Psoriasis 3 97.16 Very High Very High Very High
Mycobacterial Infection 5 93.76 High High
Lymph Node Tuberculosis 1 89.56 High High
Osteomyelitis 1 87.96 High High
Pain 4 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in vitro-in vivo extrapolation approaches were used to identify potential drug-drug interactions arising from inhibition of COD glucuronidation in humans.
Negative_regulation (inhibition) of COD associated with codeine
1) Confidence 0.31 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20484152 Disease Relevance 0 Pain Relevance 0.77
However, SM was significantly decreased in patients receiving ACE inhibitors (51.3 mg/dl versus 49.7 mg/dl, p = 0.015) but not in controls taking this medication (44.3 mg/dl versus 42.8 mg/dl, p = 0.309) (Table 3).


Negative_regulation (decreased) of SM
2) Confidence 0.24 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.78 Pain Relevance 0.08
The combination of INH, RFP and SM was applied initially and then SM was replaced by CS due to its side effect.
Negative_regulation (replaced) of SM
3) Confidence 0.11 Published 1995 Journal Kekkaku Section Abstract Doc Link 7760539 Disease Relevance 0.74 Pain Relevance 0.08
Our data indicate a blunted SM response to hGH in group B diabetic subjects; this defect in SM generation is apparently not present in group A subjects.
Negative_regulation (defect) of SM associated with diabetes mellitus
4) Confidence 0.09 Published 1985 Journal Diabetes Section Abstract Doc Link 3967801 Disease Relevance 0.35 Pain Relevance 0.13
The research group of Goodman worked on the cytostatic and cytotoxic properties of SM and its nitrogen relatives during World War II.3 This research was declassified after World War II and resulted in medical applications of alkylating mustard compounds, for example, the first successful therapy of leukemia.3 The cytostatic effect of SM was also used to treat hyperproliferative skin diseases, for example, psoriasis.4 In addition, recognition of SM as an immunosuppressant compound prompted studies about chemical immunosuppression.
Negative_regulation (effect) of SM in skin associated with psoriasis, leukemia and skin diseases
5) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.45 Pain Relevance 0.05
SM is effectively eliminated by glutathione.
Negative_regulation (eliminated) of SM
6) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.07 Pain Relevance 0
The remaining 80% to 90% are rapidly transported away by circulation.7,11 Recently, evidence has accumulated that unhydrolyzed mustard even remains present in the stratum corneum and the upper epidermis.7 This finding could explain the occurrence of secondary blisters even 30 days after termination of SM exposure.12
Negative_regulation (termination) of SM in upper associated with blister
7) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.18 Pain Relevance 0
The proportion of "large" smIPSPs was reduced, but a loss of "small" smIPSPs also contributed to the reduction in smIPSP frequency.
Negative_regulation (loss) of smIPSPs
8) Confidence 0.01 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 8478686 Disease Relevance 0 Pain Relevance 0.65
The smIPSPs were blocked by the GABAA antagonist bicuculline.
Negative_regulation (blocked) of smIPSPs associated with antagonist
9) Confidence 0.01 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 8478686 Disease Relevance 0 Pain Relevance 0.59

General Comments

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