INT39416

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Context Info
Confidence 0.64
First Reported 1985
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 81
Total Number 83
Disease Relevance 45.17
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
plasma cells 5
T-cell 5
intestine 3
nasal 3
epithelial cells 3
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 613 100.00 Very High Very High Very High
chemokine 101 99.46 Very High Very High Very High
Inflammation 473 99.14 Very High Very High Very High
Morphine 12 98.80 Very High Very High Very High
medulla 2 95.24 Very High Very High Very High
tolerance 10 93.56 High High
Bile 175 90.72 High High
headache 11 86.52 High High
opioid receptor 1 86.00 High High
Pain 26 84.12 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 474 99.98 Very High Very High Very High
Diffuse Large B-cell Lymphoma 71 99.98 Very High Very High Very High
Follicular Lymphoma 30 99.98 Very High Very High Very High
Immunization 824 99.92 Very High Very High Very High
Chlamydia Infection 594 99.80 Very High Very High Very High
Food Poisoning 2 99.52 Very High Very High Very High
Infection 816 99.50 Very High Very High Very High
Disease 819 99.48 Very High Very High Very High
Influenza Virus Infection 384 99.20 Very High Very High Very High
INFLAMMATION 443 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine resulted in a highly significant inhibition of CT-specific IgA and IgG production in fragment culture supernatants of all three tissues compared with placebo.
Gene_expression (production) of IgA associated with morphine
1) Confidence 0.64 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.31 Pain Relevance 0.89
In order to know whether HET enhances a basal level of secretory IgA production in the mucosal site, total IgA titer in intestinal washes were measured.
Gene_expression (production) of IgA
2) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.40 Pain Relevance 0
In contrast to IgG, locally produced IgA may interact intracellularly with M2e during its pIgR-mediated transport through infected epithelial cells and thereby restrict virus replication [55].
Gene_expression (produced) of IgA in epithelial cells
3) Confidence 0.49 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.07 Pain Relevance 0
The fact that we could not detect significant M2e(pep-nat)-specific IgA in pooled sera of i.n. vaccinated mice (data not shown) does not exclude the possibility that M2e(pep-nat)-specific IgA was produced locally and efficiently transported into airway secretions.
Gene_expression (produced) of IgA
4) Confidence 0.49 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.07 Pain Relevance 0
In order to analyze the effect of HET on IgA immune response against intestinal antigen, HET was administered to mice at a dose of 1000 mg kg?
Gene_expression (response) of IgA
5) Confidence 0.47 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0
Orally administered HET enhanced IgA immune response in not only intestinal mucosa but also nasal mucosa against orally administered OVA-microparticles.
Gene_expression (response) of IgA in nasal mucosa
6) Confidence 0.47 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0.05
Once produced by mature plasma cells, IgA is transported onto the mucosal surface, where it interacts with invading pathogens by inhibiting their adherence and forming immune complexes (6).
Gene_expression (produced) of IgA in plasma cells
7) Confidence 0.42 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.15 Pain Relevance 0
Peyer's patch is the important lymphoid tissues in the intestine, and are known as the inductive sites for IgA production (10).
Gene_expression (production) of IgA in intestine
8) Confidence 0.42 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0
Most of the IgA producing B cells and plasma cells are found in close proximity to the IEC, which lie on the surface of the intestine.
Gene_expression (producing) of IgA in intestine
9) Confidence 0.42 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.36 Pain Relevance 0.23
The expression of IgA was evaluated immunohistochemically under a fluorescent microscope as described previously [24].


Gene_expression (expression) of IgA
10) Confidence 0.41 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.09 Pain Relevance 0.03
As shown in Fig. 6, the expression of IgA in the control group increased after BDL, peaked on day 3, and decreased thereafter.
Gene_expression (expression) of IgA
11) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.05
BDL induced the expression of IgA in the intestine
Gene_expression (expression) of IgA in intestine
12) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.10
Thus, we analyzed the expression of IgA in the colon from BDL-treated animals.
Spec (analyzed) Gene_expression (expression) of IgA in colon
13) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.07
Colonic expression of IgA markedly increased after BDL.
Gene_expression (expression) of IgA
14) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.05
However, the expression of IgA in animals pretreated with antibiotics was extremely low.
Gene_expression (expression) of IgA
15) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.07
We also found that BDL markedly increased the mucosal expression of IgA in the colon by a mechanism that was suppressed by antibiotics (Fig. 6).
Gene_expression (expression) of IgA in colon
16) Confidence 0.31 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.50 Pain Relevance 0.28
Although the expression of IgA was low in iNOS?
Gene_expression (expression) of IgA
17) Confidence 0.31 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.08
Given that antibodies are extraordinarily powerful at neutralizing virus, preventing further infection, clearing antigen and even dampening inflammation via FcR ligation, the accelerated IgG and IgA responses in the lung most likely contribute, at least partially, to the enhanced viral clearance in PCN-treated mice.
Gene_expression (responses) of IgA in lung associated with inflammation and infection
18) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.77 Pain Relevance 0.12
In the present study, although maternal allergen-specific IgG1, IgA and IgE were present at weaning in naïve FcRn-sufficient mice foster nursed by allergic mothers, it appeared that allergen-specific IgG1 was the only isotype whose levels were sustained until allergic sensitization.
Gene_expression (present) of IgA associated with hypersensitivity
19) Confidence 0.28 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.08 Pain Relevance 0
As virus-specific IgA was detectable after i.n. but not i.m. rAd immunization, the role of this response in enhanced protection was examined.
Gene_expression (detectable) of IgA associated with immunization
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953831 Disease Relevance 0.72 Pain Relevance 0

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