INT39419

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.19
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
brain 4
liver 2
Tdo2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
Paracetamol 7 99.86 Very High Very High Very High
aspirin 5 98.08 Very High Very High Very High
monoamine 1 94.72 High High
Neurotransmitter 1 72.80 Quite High
fluoxetine 2 50.00 Quite Low
anesthesia 1 25.00 Low Low
sSRI 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 1 98.72 Very High Very High Very High
Suicidal Behaviour 1 92.40 High High
Hepatic Porphyrias 2 42.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: It is suggested that major mechanism of action of fluoxetine is that of elevating brain tryptophan concentration and hence 5-HT synthesis by increasing the availability of circulating tryptophan to the brain secondarily to inhibition of major tryptophan degrading enzyme, hepatic tryptophan pyrrolase.
Positive_regulation (increasing) of Negative_regulation (inhibition) of tryptophan pyrrolase in brain
1) Confidence 0.43 Published 2003 Journal J Coll Physicians Surg Pak Section Body Doc Link 12685966 Disease Relevance 0 Pain Relevance 0
The results show that acetaminophen alone increases brain serotonin as well as norepinephrine levels with a concomitant inhibition of liver TDO activity.
Positive_regulation (increases) of Negative_regulation (inhibition) of TDO in liver associated with paracetamol and serotonin
2) Confidence 0.43 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214507 Disease Relevance 0 Pain Relevance 1.09
We have shown that this event results in marked impairment of hepatic tryptophan pyrrolase activity and consequently in elevated tryptophan content and enhanced 5-hydroxytryptamine (5-HT) turnover in the brain of such porphyric rats.
Positive_regulation (results) of Negative_regulation (impairment) of pyrrolase in brain
3) Confidence 0.32 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3968635 Disease Relevance 0.19 Pain Relevance 0

General Comments

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