INT39443

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.31
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
plasma 2
mononuclear cells 2
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 10 99.70 Very High Very High Very High
aspirin 11 98.48 Very High Very High Very High
Pain 3 78.92 Quite High
Inflammation 1 73.84 Quite High
palliative 1 73.52 Quite High
cva 24 67.92 Quite High
ischemia 9 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloidosis 5 99.32 Very High Very High Very High
Thrombosis 13 98.40 Very High Very High Very High
Coagulation Disorder 2 97.76 Very High Very High Very High
Cancer 10 96.68 Very High Very High Very High
Thrombophilia 3 92.32 High High
Cv General 4 Under Development 13 91.28 High High
Disease 1 91.00 High High
Infection 2 88.52 High High
Ovarian Hyperstimulation Syndrome 1 88.04 High High
Hemorrhage 12 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their decreasing order of activity in enhancing the elevated prothrombin time was phenylbutazone, diflunisal, acetylsalicylic acid, ibuprofen, indomethacin, tolmetin sodium, and ketoprofen.
Positive_regulation (enhancing) of Positive_regulation (elevated) of prothrombin associated with aspirin
1) Confidence 0.70 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
With the exception of amfenac sodium, all the NSAIDs significantly enhanced the elevated prothrombin time when administered 18 hr after warfarin.
Positive_regulation (enhanced) of Positive_regulation (elevated) of prothrombin associated with cinod
2) Confidence 0.50 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
Tumor cells can either directly activate the blood clotting system or indirectly stimulate mononuclear cells to synthesize and express various procoagulants, subsequently leading to prothrombin activation, fibrin formation, and generation of a thrombus.
Positive_regulation (leading) of Positive_regulation (activation) of prothrombin in mononuclear cells associated with coagulation disorder, cancer and thrombosis
3) Confidence 0.19 Published 1999 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 10357083 Disease Relevance 1.71 Pain Relevance 0.11
The physiopathologic process is not well known, although it is known that neoplastic cells interact with the thrombin and plasmin generating systems and that there is also a decrease in coagulation inhibitors, all of which leads to prothrombin activation in the absence of the corresponding increases in thrombin inhibitor complexes.
Positive_regulation (leads) of Positive_regulation (activation) of prothrombin
4) Confidence 0.17 Published 1998 Journal An Med Interna Section Abstract Doc Link 9882859 Disease Relevance 1.16 Pain Relevance 0.11
This is the first report of increased in vivo prothrombin activation and activity in AL-associated FX deficiency.
Positive_regulation (increased) of Positive_regulation (activation) of prothrombin associated with amyloidosis
5) Confidence 0.04 Published 1995 Journal Thromb. Res. Section Abstract Doc Link 8585046 Disease Relevance 0.97 Pain Relevance 0.14
In addition, plasmin mediated activation of the coagulation system has been shown to be important, as judged by plasma increases of markers of prothrombin activation and thrombin activity (Eisenberg et al, JACC 2002).
Positive_regulation (increases) of Positive_regulation (activation) of prothrombin in plasma
6) Confidence 0.01 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.33 Pain Relevance 0

General Comments

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