INT39444

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 5.82
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
hepatocytes 2
platelet 2
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 5 98.12 Very High Very High Very High
cINOD 6 95.76 Very High Very High Very High
aspirin 3 93.68 High High
ischemia 1 90.40 High High
Analgesic 1 84.96 Quite High
Inflammation 53 80.44 Quite High
Pain 2 78.20 Quite High
anesthesia 1 67.48 Quite High
cytokine 2 58.56 Quite High
cva 13 50.68 Quite High
Disease Link Frequency Relevance Heat
Amyloidosis 9 100.00 Very High Very High Very High
Thrombosis 7 100.00 Very High Very High Very High
Pressure And Volume Under Development 35 99.84 Very High Very High Very High
Fever 52 98.64 Very High Very High Very High
Cv General 3 Under Development 7 98.12 Very High Very High Very High
Coagulation Disorder 1 97.96 Very High Very High Very High
Ulcers 1 95.64 Very High Very High Very High
Disease 15 95.20 Very High Very High Very High
Thrombosis Related Under Development 1 94.96 High High
Lymphatic System Cancer 2 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the 24-hr pretreatment time, only phenylbutazone significantly reduced the elevated prothrombin time.
Negative_regulation (reduced) of Positive_regulation (elevated) of prothrombin
1) Confidence 0.59 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.46
[Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state].
Negative_regulation (thrombosis) of Positive_regulation (carrying) of prothrombin associated with thrombosis
2) Confidence 0.42 Published 1999 Journal J Fr Ophtalmol Section Title Doc Link 10609175 Disease Relevance 0.82 Pain Relevance 0.11
Whether the new antithrombins represent a major advance over heparin is less clear as prothrombin activation is not blocked and rebound is seen as a result.
Negative_regulation (blocked) of Positive_regulation (activation) of prothrombin
3) Confidence 0.17 Published 1995 Journal Eur. Heart J. Section Abstract Doc Link 8869022 Disease Relevance 0.24 Pain Relevance 0.20
Changes in clinical pathology parameters included decreases in red blood cell count, hemoglobin, and hematocrit mean values; elevation in platelet counts; and an increase in prothrombin and activated partial thromboplastin times.
Spec (partial) Negative_regulation (decreases) of Spec (partial) Positive_regulation (increase) of prothrombin in platelet
4) Confidence 0.16 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812216 Disease Relevance 0.82 Pain Relevance 0.12
Inhibition of factor VIIa generation and prothrombin activation by treatment with enoxaparin in patients with unstable angina.
Negative_regulation (Inhibition) of Positive_regulation (activation) of prothrombin associated with angina
5) Confidence 0.09 Published 2003 Journal Br. J. Haematol. Section Title Doc Link 12588347 Disease Relevance 0.19 Pain Relevance 0.19
As the number of functioning hepatocytes decrease, the prothrombin time elevates.
Negative_regulation (decrease) of Positive_regulation (elevates) of prothrombin in hepatocytes
6) Confidence 0.05 Published 2010 Journal Journal of the American Academy of Nurse Practitioners Section Body Doc Link PMC3017746 Disease Relevance 1.30 Pain Relevance 0.03
This is the first report of increased in vivo prothrombin activation and activity in AL-associated FX deficiency.
Negative_regulation (deficiency) of Positive_regulation (activation) of prothrombin associated with amyloidosis
7) Confidence 0.04 Published 1995 Journal Thromb. Res. Section Abstract Doc Link 8585046 Disease Relevance 0.96 Pain Relevance 0.13
Hypercoagulation in attack-free period in FMF was characterized by shortened prothrombin time and thrombin time, decreased protein C activity and elevation of prothrombin fragment F1+2 [56].
Negative_regulation (decreased) of Positive_regulation (elevation) of prothrombin associated with fever
8) Confidence 0.01 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847313 Disease Relevance 1.41 Pain Relevance 0.18

General Comments

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