INT39447

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Context Info
Confidence 0.37
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.60
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
foot 1
Scr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 21 99.60 Very High Very High Very High
analgesia 7 96.08 Very High Very High Very High
ischemia 39 93.08 High High
bradykinin 30 87.92 High High
agonist 15 78.80 Quite High
Analgesic 1 73.44 Quite High
Inflammation 73 69.32 Quite High
cytokine 18 59.44 Quite High
Inflammatory response 12 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 96 97.28 Very High Very High Very High
Cv Unclassified Under Development 36 93.08 High High
INFLAMMATION 88 69.32 Quite High
Injury 7 67.72 Quite High
Apoptosis 18 64.00 Quite High
Death 18 61.52 Quite High
Chronic Renal Failure 49 50.00 Quite Low
Kidney Stones 19 50.00 Quite Low
Targeted Disruption 31 44.28 Quite Low
Renal Disease 6 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCR was markedly depressed in the foot in 15 of 17 patients, at T12-L1 in 12 of 17, at T9 in 10 of 17, at T5 in 9 of 16 and in the hand in 6 of 17.
Negative_regulation (depressed) of SCR in foot
1) Confidence 0.37 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3976323 Disease Relevance 0 Pain Relevance 0.46
B1KO had a significant reduction in sCr at all times analyzed, meanwhile B2KO mice presented lower sCr values only at 4 and 24 h.
Negative_regulation (reduction) of sCr
2) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.31 Pain Relevance 0.26
Moreover, B1R antagonism (R-954) significantly reduced sCr levels at 24 hours (0.93±0.40 in treated versus 2.22±0.14 mg/dL in untreated animals, p?
Negative_regulation (reduced) of sCr
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.68 Pain Relevance 0.25
Moreover, we found that B1R antagonist R-954 also able to reduce sCr levels.
Negative_regulation (reduce) of sCr associated with antagonist
4) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.61 Pain Relevance 0.26
For example, when testing for an interaction effect on SCr between age and the rs4293393-T allele count, the null model included as covariates age, sex and the rs4293393-T allele count.
Negative_regulation (effect) of SCr
5) Confidence 0.16 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0 Pain Relevance 0

General Comments

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