INT39448

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.18
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sympathetic 1
foot 1
Scr (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 3 99.64 Very High Very High Very High
antagonist 35 99.46 Very High Very High Very High
agonist 25 97.72 Very High Very High Very High
analgesia 21 96.40 Very High Very High Very High
bradykinin 50 93.12 High High
ischemia 65 92.80 High High
Inflammation 122 71.20 Quite High
cytokine 31 59.16 Quite High
Inflammatory response 20 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 160 99.36 Very High Very High Very High
Myocardial Infarction 9 98.98 Very High Very High Very High
Diabetes Mellitus 32 98.18 Very High Very High Very High
Hypertension 42 97.68 Very High Very High Very High
Cv Unclassified Under Development 60 92.80 High High
Apoptosis 30 91.12 High High
Chronic Renal Failure 98 88.84 High High
Death 30 88.64 High High
Increased Venous Pressure Under Development 6 86.48 High High
INFLAMMATION 147 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In four cases of five with an analgesic level T1-T2, the SCR was preserved in the hand.
Gene_expression (preserved) of SCR associated with analgesic
1) Confidence 0.67 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3976323 Disease Relevance 0 Pain Relevance 0.65
Total abolition of the SCR in the foot was accomplished in only seven cases and sympathetic activity reappeared long before regression of analgesia or motor blockade was observed.
Gene_expression (abolition) of SCR in sympathetic associated with analgesia
2) Confidence 0.58 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3976323 Disease Relevance 0 Pain Relevance 0.60
SCR was markedly depressed in the foot in 15 of 17 patients, at T12-L1 in 12 of 17, at T9 in 10 of 17, at T5 in 9 of 16 and in the hand in 6 of 17.
Gene_expression (depressed) of SCR in foot
3) Confidence 0.58 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3976323 Disease Relevance 0 Pain Relevance 0.46
Moreover, B1R antagonism (R-954) significantly reduced sCr levels at 24 hours (0.93±0.40 in treated versus 2.22±0.14 mg/dL in untreated animals, p?
Gene_expression (levels) of sCr
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.69 Pain Relevance 0.25
In this case, sCr levels were unaffected (2.22±0.14 in untreated versus 1.95±0.20 mg/dL in treated animals).


Gene_expression (levels) of sCr
5) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.81 Pain Relevance 0.25
Moreover, we found that B1R antagonist R-954 also able to reduce sCr levels.
Gene_expression (levels) of sCr associated with antagonist
6) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.61 Pain Relevance 0.26
Concerning B2R and renal IRI, our previous paper showed that sCr levels were slightly lower in B2KO when compared to wild-type mice.
Gene_expression (levels) of sCr associated with reperfusion injury
7) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.65 Pain Relevance 0.25
B1KO had a significant reduction in sCr at all times analyzed, meanwhile B2KO mice presented lower sCr values only at 4 and 24 h.
Gene_expression (values) of sCr
8) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.35 Pain Relevance 0.26
Incomplete information regarding history of HTN (5,705 cases), type 2 DM (1,422 cases) and myocardial infarction (MI, 2,551 cases) was available for the Icelandic SCr sample set.
Gene_expression (sample) of SCr associated with diabetes mellitus, hypertension and myocardial infarction
9) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 1.31 Pain Relevance 0
The Icelandic SCr measurements came from both laboratories, the Laboratory in Mjodd (N?
Gene_expression (measurements) of SCr
10) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.68 Pain Relevance 0
Therefore, following transfection of SCR, SMS1 or SMS2 siRNA, the cells were tested for CD11b expression after 48 hours of differentiation (Figure 3B).
Gene_expression (transfection) of SCR
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
In order to obtain structural insight into the fH–glycosamino­glycan recognition event, crystals were grown of a three SCR-domain construct comprising domains 6, 7 and 8 (fH678) in complex with sucrose octasulfate (SOS; Prosser, Johnson, Roversi, Herbert et al., 2007 ?)
Gene_expression (grown) of SCR
12) Confidence 0.04 Published 2010 Journal Acta Crystallographica Section D: Biological Crystallography Section Body Doc Link PMC2852306 Disease Relevance 0 Pain Relevance 0
Case study 2: the crystal structure of a complex between SCR domains 6 and 7 from complement regulator factor H and the factor H-binding neisserial protein fHbp
Gene_expression (domains) of SCR
13) Confidence 0.04 Published 2010 Journal Acta Crystallographica Section D: Biological Crystallography Section Body Doc Link PMC2852306 Disease Relevance 0.07 Pain Relevance 0

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