INT39453

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.98
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TCN2) extracellular region (TCN2)
Anatomy Link Frequency
liver 1
vitreous humor 1
brain 1
B12 1
urine 1
TCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 99.50 Very High Very High Very High
antagonist 8 99.44 Very High Very High Very High
Analgesic 3 98.76 Very High Very High Very High
depression 4 98.52 Very High Very High Very High
Pain 5 98.18 Very High Very High Very High
Calcium channel 4 96.84 Very High Very High Very High
cINOD 11 92.68 High High
ischemia 4 89.96 High High
nud 1 67.20 Quite High
cva 3 62.68 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 99.50 Very High Very High Very High
Multiple Organ Failure 5 99.40 Very High Very High Very High
Infection 44 98.74 Very High Very High Very High
Depression 4 98.52 Very High Very High Very High
Pain 3 98.18 Very High Very High Very High
Squamous Cell Carcinoma 5 95.64 Very High Very High Very High
Pernicious Anemia 5 92.52 High High
INFLAMMATION 12 92.48 High High
Cancer 100 90.40 High High
Heart Rate Under Development 3 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lactate metabolism remained normal during APST II (lactate extraction 12 +/- 3% vs -28 +/- 8% (APST I) at maximal pacing rates [p less than 0.05]), while ST-segment depression, LV end-diastolic pressure postpacing and angina were also significantly reduced during APST II.
Negative_regulation (reduced) of APST II associated with angina and depression
1) Confidence 0.59 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 3976504 Disease Relevance 0.42 Pain Relevance 0.24
Although most hemodynamic changes were observed only during the infusion, contractility and LV systolic pressure were still diminished at the beginning of APST II and remained so during pacing, resulting in a reduction in myocardial oxygen demand compared to APST I.
Negative_regulation (diminished) of APST II
2) Confidence 0.43 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 3976504 Disease Relevance 0.45 Pain Relevance 0.13
Screening procedures in biosamples (whole blood, plasma, serum, urine, vitreous humor, brain, liver or hair) of humans or animals (horse, or rat) are included for the following drug classes: angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (AT-II) blockers, anticoagulants of the 4-hydroxy coumarin type, barbiturates, dihydropyridine calcium channel blockers (calcium antagonists), diuretics, hypoglycemic sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (blockers) of AT-II in urine associated with inflammation, antagonist, calcium channel and cinod
3) Confidence 0.27 Published 1999 Journal J. Chromatogr. B Biomed. Sci. Appl. Section Abstract Doc Link 10572972 Disease Relevance 0.09 Pain Relevance 0.28
Novel observations point to the hypothesis that intracerebral resveratrol treatment diminishes the sensitivity of rats to pain, and that the said analgesic action of resveratrol is a central mechanism mediated by the inhibition of cycloxygenases I and II.
Negative_regulation (inhibition) of and II associated with pain and analgesic
4) Confidence 0.23 Published 2008 Journal Antioxid. Redox Signal. Section Abstract Doc Link 18092939 Disease Relevance 0.18 Pain Relevance 0.27
In experimental conditions, D. aurita has been described as being able to maintain stable infection by TCI isolates while having the capacity to control and even eliminate TCII isolates.
Negative_regulation (eliminate) of TCII associated with infection
5) Confidence 0.15 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2695024 Disease Relevance 0.31 Pain Relevance 0
Screening procedures in biosamples (whole blood, plasma, serum, urine, vitreous humor, brain, liver or hair) of humans or animals (horse, or rat) are included for the following drug classes: angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (AT-II) blockers, anticoagulants of the 4-hydroxy coumarin type, barbiturates, dihydropyridine calcium channel blockers (calcium antagonists), diuretics, hypoglycemic sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (blockers) of AT-II in liver associated with inflammation, antagonist, calcium channel and cinod
6) Confidence 0.09 Published 1999 Journal J. Chromatogr. B Biomed. Sci. Appl. Section Abstract Doc Link 10572972 Disease Relevance 0.09 Pain Relevance 0.28
Screening procedures in biosamples (whole blood, plasma, serum, urine, vitreous humor, brain, liver or hair) of humans or animals (horse, or rat) are included for the following drug classes: angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (AT-II) blockers, anticoagulants of the 4-hydroxy coumarin type, barbiturates, dihydropyridine calcium channel blockers (calcium antagonists), diuretics, hypoglycemic sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (blockers) of AT-II in vitreous humor associated with inflammation, antagonist, calcium channel and cinod
7) Confidence 0.09 Published 1999 Journal J. Chromatogr. B Biomed. Sci. Appl. Section Abstract Doc Link 10572972 Disease Relevance 0.09 Pain Relevance 0.28
Screening procedures in biosamples (whole blood, plasma, serum, urine, vitreous humor, brain, liver or hair) of humans or animals (horse, or rat) are included for the following drug classes: angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (AT-II) blockers, anticoagulants of the 4-hydroxy coumarin type, barbiturates, dihydropyridine calcium channel blockers (calcium antagonists), diuretics, hypoglycemic sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (blockers) of AT-II in brain associated with inflammation, antagonist, calcium channel and cinod
8) Confidence 0.09 Published 1999 Journal J. Chromatogr. B Biomed. Sci. Appl. Section Abstract Doc Link 10572972 Disease Relevance 0.09 Pain Relevance 0.28
The present study shows that, unlike ranitidine, ebrotidine, a competitive H2-receptor antagonist, is also a non-competitive inhibitor of carbonic anhydrase I and II.
Negative_regulation (inhibitor) of and II associated with antagonist
9) Confidence 0.07 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205766 Disease Relevance 0.21 Pain Relevance 0.30
Studies in Africa and the USA have shown higher vitamin B12 and transcobalamin II levels in black than in white individuals.
Negative_regulation (shown) of transcobalamin II in B12
10) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.20 Pain Relevance 0.06
In a recent in vitro study by Karioti et al. [118], hypericin and in a higher extent pseudohypericin inhibited in the dark thioredoxin reductase I and II.
Negative_regulation (inhibited) of and II
11) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.48 Pain Relevance 0
The hourly decreases in APACHE II, SAPS II, and MODS scores were noted to be most significant during the ED stay, as compared with scores computed during the subsequent 72 hours in the ICU.
Negative_regulation (decreases) of APACHE II associated with multiple organ failure
12) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1269432 Disease Relevance 0.37 Pain Relevance 0

General Comments

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