INT39457

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 22.80
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
joints 1
hepatocytes 1
lymphocytes 1
lung 1
T cells 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 269 99.98 Very High Very High Very High
Inflammation 440 99.92 Very High Very High Very High
lidocaine 33 99.76 Very High Very High Very High
methotrexate 36 99.74 Very High Very High Very High
Potency 46 99.52 Very High Very High Very High
rheumatoid arthritis 314 99.48 Very High Very High Very High
Inflammatory response 37 98.92 Very High Very High Very High
Osteoarthritis 336 97.80 Very High Very High Very High
corticosteroid 13 91.76 High High
cINOD 11 87.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 443 99.92 Very High Very High Very High
Rheumatoid Arthritis 404 99.48 Very High Very High Very High
Hepatitis C Virus Infection 236 99.28 Very High Very High Very High
Obesity 541 99.20 Very High Very High Very High
Apoptosis 154 99.08 Very High Very High Very High
Disease 209 99.00 Very High Very High Very High
Breast Cancer 8 98.76 Very High Very High Very High
Osteoarthritis 272 97.80 Very High Very High Very High
Opiate Addiction 158 95.84 Very High Very High Very High
Metastasis 8 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lidocaine-mediated inhibition of cellular cholesteryl ester formation triggered an enhanced intracellular ACAT activity that was not fully expressed in the presence of lidocaine.
Positive_regulation (enhanced) of ACAT associated with lidocaine
1) Confidence 0.67 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3977319 Disease Relevance 0.14 Pain Relevance 1.07
Indeed, FP inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase).
Positive_regulation (activation) of STAT in lung
2) Confidence 0.49 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11673549 Disease Relevance 0.64 Pain Relevance 0.45
The activation of ACAT activity by lidocaine might represent a compensatory mechanism by which the inhibitory effect of lidocaine was partially overcome with time.
Positive_regulation (activation) of ACAT associated with lidocaine
3) Confidence 0.45 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3977319 Disease Relevance 0.14 Pain Relevance 1.05
The lidocaine-mediated inhibition of cellular cholesteryl ester formation triggered an enhanced intracellular ACAT activity that was not fully expressed in the presence of lidocaine.
Positive_regulation (triggered) of ACAT associated with lidocaine
4) Confidence 0.45 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3977319 Disease Relevance 0.14 Pain Relevance 1.07
All underwent both Routine NCS/nEMG studies and NC-stat EDX.
Positive_regulation (underwent) of NC-stat EDX
5) Confidence 0.33 Published 2008 Journal Acta Neurol. Scand. Section Body Doc Link 18355396 Disease Relevance 0.09 Pain Relevance 0
Eltrombopag has high potency in in vitro assays for activation of the STAT and MAPK signaling pathways.
Positive_regulation (activation) of STAT associated with potency
6) Confidence 0.27 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0 Pain Relevance 0.09
The activation of STAT has been investigated to determine whether BMI may affect the leptin signalling pathway.
Positive_regulation (activation) of STAT associated with obesity
7) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.14 Pain Relevance 0.10
The highest adipokine concentration induced an early activation of STAT 1?
Positive_regulation (activation) of STAT
8) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.12 Pain Relevance 0.10
The level of STAT activation increased with the BMI, but the difference between both groups of patients did not reach statistical significance.


Positive_regulation (activation) of STAT associated with obesity
9) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.29 Pain Relevance 0.14
The activation of the Janus kinase/STAT pathway has been investigated to determine whether the leptin-induced signal transduction process was not impaired [20].
Positive_regulation (activation) of STAT
10) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.81 Pain Relevance 0.05
Studies on OSM action on different breast cancer cell lines cytokines have suggested that the balance between STAT and ERK activation (magnitude and duration) determines growth promotion or growth inhibition [37].


Positive_regulation (activation) of STAT associated with breast cancer and cytokine
11) Confidence 0.18 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.38 Pain Relevance 0.25
This in turn activates the STAT family of transcription factors and results in the induction of Interleukin-6 and IL-6 receptor gene.
Positive_regulation (activates) of STAT
12) Confidence 0.17 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.09 Pain Relevance 0
The adipokine at 500 ng/ml triggered signal transduction through a STAT-dependent pathway while 100 ng/ml of leptin failed to activate STAT 3 but induced STAT 1?
Neg (failed) Positive_regulation (induced) of STAT
13) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911905 Disease Relevance 1.15 Pain Relevance 0.10
IL-6 and IL-6 receptor gene induction occurs as a result of activated STAT proteins and IL-6 mediates the long-term activation of STAT3 through an autocrine loop.


Positive_regulation (activated) of STAT
14) Confidence 0.12 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.30 Pain Relevance 0.03
In addition to p38 and JNK MAPK activation, we observed AKT and STAT activation in CD3+ lymphocytes.
Positive_regulation (activation) of STAT in lymphocytes
15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.97 Pain Relevance 0.46
MTX reduces JAK/STAT activation within the joints [70].
Positive_regulation (activation) of STAT in joints associated with methotrexate
16) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.69 Pain Relevance 0.54
Among the suppressor members [suppressors of cytokine signaling (SOCS)-1, 2, and 3, protein inhibitors of activated STAT (PIAS)-1, 3, x, and y] tested, SOCS-3 levels, were elevated in CD56+ T cells freshly isolated from the heroin users with or without HCV infection (Fig. 7).
Positive_regulation (activated) of STAT in T cells associated with hepatitis c virus infection, opiate addiction, infection and cytokine
17) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.57 Pain Relevance 0.05
Recent studies reveal that several Galpha subunits are capable of activating signal transducer and activator of transcription (STAT) proteins.
Positive_regulation (activating) of STAT
18) Confidence 0.10 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.07 Pain Relevance 0.22
that activates JAK/STAT pathway, inhibit HCV replication in human hepatocytes.
Positive_regulation (activates) of STAT in hepatocytes associated with hepatitis c virus infection
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.90 Pain Relevance 0.07
Multiple cytokine activated JAK/STAT signaling pathways were potently inhibited with IC50 values below 200 nM.
Positive_regulation (activated) of STAT associated with cytokine
20) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.05 Pain Relevance 0.39

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