INT39458

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 10.56
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
macrophages 1
T cells 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 11 99.50 Very High Very High Very High
cytokine 20 99.22 Very High Very High Very High
ischemia 22 98.92 Very High Very High Very High
Potency 4 97.80 Very High Very High Very High
Inflammation 43 97.44 Very High Very High Very High
Angina 4 96.28 Very High Very High Very High
local anesthetic 1 91.44 High High
agonist 19 79.20 Quite High
psoriasis 1 68.40 Quite High
Glutamate 1 55.36 Quite High
Disease Link Frequency Relevance Heat
Hypothermia 138 99.98 Very High Very High Very High
Cv General 4 Under Development 4 99.36 Very High Very High Very High
Infection 136 98.18 Very High Very High Very High
Atherosclerosis 31 98.08 Very High Very High Very High
Hepatitis C Virus Infection 234 97.98 Very High Very High Very High
Opiate Addiction 158 97.80 Very High Very High Very High
INFLAMMATION 48 97.44 Very High Very High Very High
Myocardial Infarction 8 97.04 Very High Very High Very High
Cv General 3 Under Development 5 96.28 Very High Very High Very High
Lymphatic System Cancer 22 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine was capable of directly inhibiting acyl-CoA:cholesterol acyltransferase (ACAT) activity in broken cell homogenates.
Negative_regulation (inhibiting) of ACAT associated with lidocaine
1) Confidence 0.57 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3977319 Disease Relevance 0.15 Pain Relevance 1.08
In the near future, drugs as beta-glucans, Apo-A1 mimetic peptides, and ACAT inhibitors, are the new promises to treat this condition.
Negative_regulation (inhibitors) of ACAT
2) Confidence 0.42 Published 2008 Journal Am J Ther Section Abstract Doc Link 18645343 Disease Relevance 1.21 Pain Relevance 0.10
The SM concentration is also significantly increased in macrophages treated with acetyl-LDL plus an acyl-CoA:cholesterol acyltransferase inhibitor [11].
Negative_regulation (inhibitor) of cholesterol acyltransferase in macrophages
3) Confidence 0.08 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.88 Pain Relevance 0
Among the suppressor members [suppressors of cytokine signaling (SOCS)-1, 2, and 3, protein inhibitors of activated STAT (PIAS)-1, 3, x, and y] tested, SOCS-3 levels, were elevated in CD56+ T cells freshly isolated from the heroin users with or without HCV infection (Fig. 7).
Negative_regulation (inhibitors) of STAT in T cells associated with hepatitis c virus infection, opiate addiction, infection and cytokine
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.58 Pain Relevance 0.05
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Negative_regulation (inhibitors) of STAT associated with hepatitis c virus infection, opiate addiction, infection and cytokine
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 1.88 Pain Relevance 0.05
Moderate hypothermia abolished hepatic STAT activity in an intestinal ischemia-reperfusion rat model, suggesting a hepatoprotective role for induced hypothermia as well [104].
Negative_regulation (abolished) of STAT associated with hypothermia, cv general 4 under development and ischemia
6) Confidence 0.05 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.07 Pain Relevance 0.25
B, AP-1, STAT, NFAT), and inhibiting the activity and
Negative_regulation (inhibiting) of STAT
7) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.34 Pain Relevance 0.30
This data suggests that deregulation of STAT activity may play a role in Vorinostat resistance.
Negative_regulation (deregulation) of STAT
8) Confidence 0.02 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox