INT39459

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.62
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
macrophages 1
T cells 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 11 99.20 Very High Very High Very High
cytokine 57 94.68 High High
Potency 1 89.72 High High
antagonist 1 85.24 High High
local anesthetic 1 83.36 Quite High
chemokine 5 74.44 Quite High
Inflammation 53 67.60 Quite High
cINOD 2 60.00 Quite High
Central nervous system 6 59.32 Quite High
Multiple sclerosis 1 57.04 Quite High
Disease Link Frequency Relevance Heat
Infection 201 99.72 Very High Very High Very High
Hepatitis C Virus Infection 351 99.52 Very High Very High Very High
Opiate Addiction 237 99.34 Very High Very High Very High
Hypoxia 2 94.88 High High
Cancer 81 93.60 High High
Adenocarcinoma 43 87.92 High High
Apoptosis 16 84.80 Quite High
Alzheimer's Dementia 3 82.72 Quite High
Leiomyosarcoma 59 80.48 Quite High
Diabetes Mellitus 3 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lidocaine-mediated inhibition of cellular cholesteryl ester formation triggered an enhanced intracellular ACAT activity that was not fully expressed in the presence of lidocaine.
Neg (not) Gene_expression (expressed) of ACAT associated with lidocaine
1) Confidence 0.75 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3977319 Disease Relevance 0.14 Pain Relevance 1.07
Statistical analysis
Gene_expression (analysis) of Stat
2) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.08 Pain Relevance 0.03
IL18, OAS genes) or directly involved in IFN signaling (JAK/STAT), STAT1 and OAS1, OAS2, OAS3 and MxA best distinguished the two phenotypes.


Gene_expression (signaling) of STAT
3) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.35 Pain Relevance 0
We thus investigated whether heroin use or heroin use plus HCV infection suppress the expression of the key elements in JAK/STAT pathway.
Gene_expression (expression) of STAT associated with hepatitis c virus infection, opiate addiction and infection
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.79 Pain Relevance 0
For example, the biological functions of the STAT-, NF-?
Gene_expression (functions) of STAT
5) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.45 Pain Relevance 0
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Gene_expression (expression) of ACAT-1 in macrophages
6) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Gene_expression (expression) of STAT associated with hepatitis c virus infection, opiate addiction, infection and cytokine
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.33 Pain Relevance 0.05
To investigate whether heroin use or heroin use plus HCV infection has an impact on IL-12 pathway in CD56+ T cells, the transcriptional expression of key elements [IL-12 receptors, signal transducer and activator of transcription (STAT)-1, 3, 4, 5, janus kinase (JAK)-2, and tyrosine kinase (TYK)-2] in IL-12 pathway in CD56+ T cells was analyzed by the real-time RT PCR.
Gene_expression (expression) of STAT in T cells associated with hepatitis c virus infection, opiate addiction and infection
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.48 Pain Relevance 0
More recently, we have shown that PI3K, along with CK2, is involved in the classical JAK-STAT pathway of IFN-?
Gene_expression (pathway) of JAK-STAT
9) Confidence 0.06 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
Furthermore, it is well known that the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a central role in this IFN-?
Gene_expression (/) of STAT
10) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.88 Pain Relevance 0.24

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