INT39463

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 11.49
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tg) extracellular region (Tg) Golgi apparatus (Tg)
endoplasmic reticulum (Tg)
Anatomy Link Frequency
thyroid 4
follicle 1
cervical region 1
thyroid gland 1
Tg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 5 100.00 Very High Very High Very High
Pain 25 99.52 Very High Very High Very High
Inflammation 3 92.20 High High
withdrawal 8 86.40 High High
corticosteroid 1 85.92 High High
opiate 1 84.80 Quite High
cINOD 1 81.92 Quite High
anesthesia 1 81.84 Quite High
palliative 3 76.20 Quite High
Angina 1 74.84 Quite High
Disease Link Frequency Relevance Heat
Thyroid Disease 10 99.90 Very High Very High Very High
Cancer 15 99.88 Very High Very High Very High
Thyroid Neoplasm 28 99.76 Very High Very High Very High
Pain 13 99.52 Very High Very High Very High
Metastasis 12 99.40 Very High Very High Very High
Hyperthyroidism 28 99.08 Very High Very High Very High
Cv General 3 Under Development 3 98.84 Very High Very High Very High
Fever 4 98.66 Very High Very High Very High
Thyroiditis 26 98.12 Very High Very High Very High
Necrosis 1 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum thyroglobulin as a manifestation of acute haemorrhage into the thyroid gland.
Positive_regulation (Elevated) of thyroglobulin in thyroid gland associated with cva
1) Confidence 0.69 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 6713690 Disease Relevance 0.45 Pain Relevance 0.27
Despite elevated sedimentation rate and increased thyroglobulin levels, nine of the patients were euthyroid, and I-131 uptake was normal in six.
Positive_regulation (increased) of thyroglobulin
2) Confidence 0.68 Published 1995 Journal Clin Nucl Med Section Abstract Doc Link 8565380 Disease Relevance 0.59 Pain Relevance 0.30
In group 2, 9 patients, who had bone pain, neurological signs or elevated serum thyroglobulin, had DTC bone metastases without iodine uptake.
Positive_regulation (elevated) of thyroglobulin associated with pain, thyroid neoplasm and metastasis
3) Confidence 0.46 Published 1993 Journal Eur J Nucl Med Section Abstract Doc Link 8299652 Disease Relevance 0.97 Pain Relevance 0.10
A 57-year-old woman with no previous personal or family history of thyroid disease developed typical subacute thyroiditis, with pain and tenderness in the anterior cervical region, fever, mild thyrotoxicosis; thyroid autoantibodies were negative, serum thyroglobulin (TG) levels were increased, radioactive iodine uptake (RAIU) values were decreased, urinary iodine excretion was normal, and erythrocyte sedimentation rate (ESR) elevated.
Positive_regulation (increased) of thyroglobulin in cervical region associated with pain, thyroiditis, thyroid disease, hyperthyroidism and fever
4) Confidence 0.42 Published 1996 Journal Thyroid Section Abstract Doc Link 8875758 Disease Relevance 1.14 Pain Relevance 0.17
Serum thyroglobulin (Tg) levels were elevated in 92% of 38 patients with subacute "painful" thyroiditis in the early stage, independent of the extent of the disease and thyroid hormone concentrations.
Positive_regulation (elevated) of thyroglobulin in thyroid associated with pain, thyroiditis and disease
5) Confidence 0.41 Published 1985 Journal Arch. Intern. Med. Section Abstract Doc Link 3977482 Disease Relevance 0.33 Pain Relevance 0.22
Serum thyroglobulin level was increased but returned to normal or decreased during and after attacks of thyroiditis.
Positive_regulation (increased) of thyroglobulin associated with thyroiditis
6) Confidence 0.14 Published 1998 Journal Endocr. J. Section Abstract Doc Link 9881913 Disease Relevance 1.18 Pain Relevance 0.24
Immunohistochemical stains of the tumor were positive for p53, thyroglobulin, and thyroid transcription factor-1.
Positive_regulation (positive) of thyroglobulin in thyroid associated with cancer
7) Confidence 0.12 Published 2005 Journal Endocr. Pathol. Section Abstract Doc Link 16299408 Disease Relevance 1.06 Pain Relevance 0.07
We observed a massive increase of thyroglobulin (Tg) concentrations in cases of DTC that started 36-48 h after SETA and did not occur in cases of ATC.
Positive_regulation (increase) of thyroglobulin associated with thyroid neoplasm
8) Confidence 0.11 Published 2007 Journal Endocr. Relat. Cancer Section Abstract Doc Link 17914113 Disease Relevance 1.30 Pain Relevance 0.23
An increase in serum thyroglobulin (Tg) ranging from 35% to 341% occurs in 33-88% of patients subjected to FNB.
Positive_regulation (increase) of thyroglobulin
9) Confidence 0.11 Published 2010 Journal Thyroid Section Body Doc Link 19785519 Disease Relevance 0 Pain Relevance 0
Laboratory tests showed hyperthyroidism and elevated levels of thyroglobulin and C-reactive protein.
Positive_regulation (elevated) of thyroglobulin associated with thyroid disease
10) Confidence 0.09 Published 2002 Journal Pediatr Hematol Oncol Section Abstract Doc Link 12051591 Disease Relevance 1.34 Pain Relevance 0.10
Currently, a phase IV trial is in progress to evaluate the efficacy of rTSH-stimulated thyroglobulin levels as the primary modality for long-term follow-up of low risk thyroid cancer patients.
Positive_regulation (rTSH-stimulated) of thyroglobulin in thyroid associated with thyroid neoplasm
11) Confidence 0.08 Published 2001 Journal Isr. Med. Assoc. J. Section Abstract Doc Link 11729583 Disease Relevance 0.54 Pain Relevance 0.19
Immunohistochemical studies showed the tumour cells to be negative for thyroglobulin and calcitonin, but positive for CEA.
Positive_regulation (negative) of thyroglobulin associated with cancer
12) Confidence 0.03 Published 2002 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 12354139 Disease Relevance 1.03 Pain Relevance 0.07
Moreover, we observed a massive increase of thyroglobulin concentrations and a moderate increase of free thyroid hormones, together with a fall of TSH concentration after 48 hours from SETA.
Positive_regulation (increase) of thyroglobulin in thyroid
13) Confidence 0.02 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2734524 Disease Relevance 0.84 Pain Relevance 0
Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73 +/- 65 vs. 65 +/- 47 pmol/l, p < 0.005, and 80 +/- 49 vs. 73 +/- 51 ng/l, p < 0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine.
Positive_regulation (higher) of thyroglobulin in follicle
14) Confidence 0.01 Published 2001 Journal Physiol Res Section Abstract Doc Link 11521733 Disease Relevance 0 Pain Relevance 0.17
During therapy, TgAb levels gradually increased in 2 of the 7 patients who were measured several times.
Positive_regulation (increased) of TgAb
15) Confidence 0.01 Published 2008 Journal Endocr. J. Section Abstract Doc Link 18490832 Disease Relevance 0.73 Pain Relevance 0.33

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