INT39468

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 13.50
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipocytes 2
heart 2
plasma 1
fat 1
capillary 1
hf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 280 98.96 Very High Very High Very High
Paracetamol 6 97.20 Very High Very High Very High
imagery 25 93.20 High High
Inflammatory response 5 79.24 Quite High
tolerance 18 72.52 Quite High
Arthritis 4 67.56 Quite High
substance P 5 42.60 Quite Low
Central nervous system 4 40.84 Quite Low
beta blocker 4 28.76 Quite Low
cytokine 15 19.56 Low Low
Disease Link Frequency Relevance Heat
Obesity 630 100.00 Very High Very High Very High
Myocardial Infarction 248 100.00 Very High Very High Very High
Body Weight 106 100.00 Very High Very High Very High
Coronary Heart Disease 24 99.74 Very High Very High Very High
Natriuresis 97 99.72 Very High Very High Very High
Cancer 66 99.42 Very High Very High Very High
Insulin Resistance 177 99.12 Very High Very High Very High
INFLAMMATION 291 98.96 Very High Very High Very High
Mitral Valve Insufficiency 9 98.20 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 1 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatic hemoglobin and plasma levels increased 10- and 5-fold, respectively, by 4.5 to 6 hr after administration of acetaminophen.
Positive_regulation (increased) of Hepatic hemoglobin in plasma associated with paracetamol
1) Confidence 0.33 Published 1985 Journal Hepatology Section Abstract Doc Link 3979955 Disease Relevance 0.36 Pain Relevance 0.41
The increase in the WAT/body weight ratio in the HF group was significantly inhibited in the HF + BOF group, but not affected in the HF + DAI group.


Positive_regulation (increase) of HF in body associated with body weight and obesity
2) Confidence 0.28 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.18 Pain Relevance 0
The average size of adipocytes in WAT was increased by >200% in the HF group.
Positive_regulation (increased) of HF in adipocytes associated with obesity
3) Confidence 0.28 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.25 Pain Relevance 0
This was evident at 2 weeks, suggesting that HF diet activated proinflammatory signaling in the intestine as early as 2 weeks after the diet intervention and this effect was maintained as long as HF diet continued (Figure 4).
Positive_regulation (activated) of HF in intestine
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 0.30 Pain Relevance 0.09
The weight of WAT and the size of adipocytes were increased in the HF group compared with those in the BD group, and these increases in the HF group were significantly inhibited in the HF + BOF group, but not affected in the HF + DAI group.
Positive_regulation (increases) of HF in adipocytes associated with obesity
5) Confidence 0.26 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266052 Disease Relevance 1.41 Pain Relevance 0.04
HF diet induced intestinal NF-?
Positive_regulation (induced) of HF
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 0.57 Pain Relevance 0.09
Findings that fecal slurries from animals fed HF diet were sufficient to enhance activation of the NF-?
Positive_regulation (fed) of HF
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 0.57 Pain Relevance 0.16
Furthermore, the presence of enteric bacteria is required for HF diet to induce TNF-?
Positive_regulation (required) of HF
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.44 Pain Relevance 0.34
Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance.
Positive_regulation (induced) of HF in fat associated with inflammation, obesity and insulin resistance
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2922379 Disease Relevance 1.14 Pain Relevance 0.16
Data from nine clinical studies that had enrolled a total of 1403 patients who received anthracycline-based therapy for advanced breast cancer showed an overall benefit from dexrazoxane in protecting cancer patients from anthracycline-induced HF (90).
Positive_regulation (induced) of HF associated with cancer, advanced or metastatic breast cancer and myocardial infarction
10) Confidence 0.21 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 1.08 Pain Relevance 0
Since circulating concentrations of natriuretic peptides are elevated in heart failure (HF) and given that clinical parameters for the evaluation and management of HF have a poor sensitivity and specificity, these peptides were a more than welcome addition to standard clinical evaluation, as a marker to identify HF.
Positive_regulation (elevated) of HF in heart associated with natriuresis and myocardial infarction
11) Confidence 0.02 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.88 Pain Relevance 0
While NT-proBNP is thought to be inert without any physiological function, BNP is biologically active and is responsible for several compensatory mechanisms in HF such as an increase of urine production and sodium excretion, a decrease of the aldosterone level, a lowering of the blood pressure and a lowering of the pulmonary capillary wedge pressure.17,18 BNP in physiological concentrations has too little effect to restore euvolemia but BNP is studied as a potential therapeutic agent in HF.19–22
Positive_regulation (increase) of HF in capillary associated with myocardial infarction
12) Confidence 0.02 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.33 Pain Relevance 0
Valvular heart disease is a common cause of HF, either by leading to volume overload (e.g. mitral regurgitation) or by causing pressure overload (e.g. aortic stenosis), and these relationships are frequently reflected in changes of NT-proBNP values.
Positive_regulation (cause) of HF in heart associated with mitral valve insufficiency, cv unclassified under development, coronary heart disease and myocardial infarction
13) Confidence 0.02 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.01 Pain Relevance 0
Especially since both the prevalence of HF and obesity are increasing in our modern society, a sensitive marker for HF in the obese population would be most welcome.43,74
Positive_regulation (increasing) of HF associated with obesity and myocardial infarction
14) Confidence 0.02 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.99 Pain Relevance 0.03

General Comments

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