INT3948

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2010
Negated 62
Speculated 47
Reported most in Abstract
Documents 291
Total Number 338
Disease Relevance 58.07
Pain Relevance 255.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
spinal cord 18
plasma 16
brain 16
spinal 9
neurons 9
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 2120 100.00 Very High Very High Very High
Morphine 383 100.00 Very High Very High Very High
antagonist 284 100.00 Very High Very High Very High
qutenza 219 100.00 Very High Very High Very High
substance P 204 100.00 Very High Very High Very High
Enkephalin 200 100.00 Very High Very High Very High
opiate 156 100.00 Very High Very High Very High
Somatostatin 143 100.00 Very High Very High Very High
Spinal cord 139 100.00 Very High Very High Very High
narcan 136 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 24 100.00 Very High Very High Very High
Body Weight 19 100.00 Very High Very High Very High
Urological Neuroanatomy 135 99.98 Very High Very High Very High
Frailty 15 99.98 Very High Very High Very High
Hyperalgesia 14 99.92 Very High Very High Very High
Lordosis 13 99.92 Very High Very High Very High
Porphyria 3 99.92 Very High Very High Very High
Vomiting 13 99.76 Very High Very High Very High
Pain 92 99.72 Very High Very High Very High
Anxiety Disorder 24 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, morphine addiction after a four-day treatment with this drug was not associated with any change in the tissue levels of CCKLM and CCK mRNA.
Regulation (change) of CCK mRNA associated with addiction, cholecystokinin and morphine
1) Confidence 0.62 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0.10 Pain Relevance 1.15
Neither CCKLM nor CCK mRNA levels were altered one hour after an acute administration of morphine (5 mg/kg i.p.).
Neg (Neither) Regulation (altered) of CCK mRNA associated with cholecystokinin and morphine
2) Confidence 0.62 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0.09 Pain Relevance 1.18
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of CCK mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
3) Confidence 0.62 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
In addition, naloxone (2 mg/kg; i.v.), did not induce any change in the extracellular level of CCK in either group.
Neg (not) Regulation (change) of CCK associated with narcan
4) Confidence 0.62 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.36
Satiety associated with premeal loads of casein is related to changes in gastrointestinal function of meal-fed animals and involves both opioid and CCK regulation.
Regulation (regulation) of CCK associated with cholecystokinin and opioid
5) Confidence 0.62 Published 2001 Journal J. Nutr. Section Abstract Doc Link 11739879 Disease Relevance 0.08 Pain Relevance 0.70
Neither dorsal rhizotomy nor combined dorsal and ventral rhizotomy affected CCK levels in either dorsal or ventral cord.
Neg (Neither) Regulation (affected) of CCK in ventral associated with dorsal rhizotomy and cholecystokinin
6) Confidence 0.62 Published 1982 Journal Brain Res. Section Abstract Doc Link 7093671 Disease Relevance 0 Pain Relevance 0.78
The effects of evodiamine on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in male rats.
Regulation (effects) of CCK in plasma associated with cholecystokinin
7) Confidence 0.62 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12464363 Disease Relevance 0.42 Pain Relevance 0.27
The effects of evodiamine on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in male rats.
Regulation (effects) of cholecystokinin in plasma associated with cholecystokinin
8) Confidence 0.62 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12464363 Disease Relevance 0.42 Pain Relevance 0.27
In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow from rat nucleus accumbens slices.
Spec (investigated) Regulation (regulation) of CCK in nucleus accumbens associated with nucleus accumbens, dopamine and cholecystokinin
9) Confidence 0.62 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2466220 Disease Relevance 0 Pain Relevance 1.12
Further on, the failure of morphine to affect the extracellular level of CCK-LI in the ACC in control animals as well as in animals with carrageenan-induced monoarthritis is in contrast to previous studies on the frontal cortex or the dorsal horn of the spinal cord, in which similar doses of morphine stimulate CCK release.
Regulation (affect) of CCK in spinal cord associated with dorsal horn, urological neuroanatomy, anterior cingulate cortex, spinal cord and morphine
10) Confidence 0.62 Published 2007 Journal Brain Res. Section Abstract Doc Link 17229410 Disease Relevance 0.55 Pain Relevance 1.68
Estrogen modulation of opioid and cholecystokinin systems in the limbic-hypothalamic circuit.
Regulation (modulation) of cholecystokinin associated with enkephalin, cholecystokinin and opioid
11) Confidence 0.62 Published 1997 Journal Brain Res. Bull. Section Title Doc Link 9370197 Disease Relevance 0.36 Pain Relevance 1.09
CCK mRNA and peptide levels fluctuate across the estrous cycle and have been shown to be modulated by estrogen exposure.
Regulation (modulated) of CCK mRNA associated with cholecystokinin
12) Confidence 0.62 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.19 Pain Relevance 0.44
The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.
Regulation (effect) of cholecystokinin in pituitary associated with aging, enkephalin, cholecystokinin and substance p
13) Confidence 0.62 Published 1995 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 8787040 Disease Relevance 0.25 Pain Relevance 0.20
We conclude that 1) CCK-LI is present in cortex, thalamus, and hypothalamus of the rat brain, 2) CCK-LI exists in two predominant molecular forms coeluting with CCK33 and CCK8, 3) both molecular forms are biologically active, and 4) concentrations of rat brain CCK33-LI are modulated by serotonergic and opiate mechanisms.
Regulation (modulated) of CCK33 in brain associated with opiate and thalamus
14) Confidence 0.62 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7001917 Disease Relevance 0 Pain Relevance 0.46
Following spinal hemisection, CCK mRNA expression increased on the ipsilateral side at the spinal segments caudal to the injury and both sides of the spinal L4-5 segments without any significant changes in CCK(B) receptor mRNA levels.
Neg (without) Regulation (changes) of CCK in spinal associated with injury and cholecystokinin
15) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19619609 Disease Relevance 0.72 Pain Relevance 1.14
In all cases (n = 6 neurons in 6 individual rats), dizocilpine inhibited the effects of CCK, PBG, and PE on RVLM presympathetic neuronal discharge.
Regulation (effects) of CCK in RVLM associated with rostral ventrolateral medulla, porphyria and cholecystokinin
16) Confidence 0.62 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15155283 Disease Relevance 0.34 Pain Relevance 1.14
After DP, the CCK secretory capacity was not affected.
Neg (not) Regulation (affected) of CCK associated with cholecystokinin
17) Confidence 0.61 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.30 Pain Relevance 0.83
Phaclofen, a selective GABA(B) antagonist, increased K+-evoked [3H]GABA release but did not affect the facilitative effect of CCK-8S.
Neg (not) Regulation (affect) of CCK-8S associated with gaba, antagonist and cholecystokinin
18) Confidence 0.61 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651144 Disease Relevance 0 Pain Relevance 1.38
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation (Effect) of cholecystokinin in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
19) Confidence 0.61 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.84
Acute or chronic administration of ethanol did not affect the cholecystokinin or enkephalin content of rat brain cortex, hypothalamus, striatum or proximal small bowel.
Neg (not) Regulation (affect) of cholecystokinin in cortex associated with enkephalin and cholecystokinin
20) Confidence 0.61 Published 1981 Journal Peptides Section Abstract Doc Link 7291043 Disease Relevance 0 Pain Relevance 0.45

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